Ten Years Recording Common Oral Clefts with a New Descriptive System

Luijsterburg, Antonius J.M.; Vermeij‐Keers, Christl

doi:10.1597/08-150

Cited by 48 publications

(65 citation statements)

References 31 publications

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“…In addition, the annual NVSCA reports 1997–2010 were used to provide an inventory of the different syndromes and chromosomal defects that had been identified postnatally 23 24. The methods of registration and validation have been described in detail elsewhere 5 20–22…”

Section: Methodsmentioning

confidence: 99%

A systematic review of associated structural and chromosomal defects in oral clefts: when is prenatal genetic analysis indicated?

et al. 2012

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Prenatal counselling regarding prognosis and risk of chromosomal defects should be tailored to cleft category, and more importantly to the presence/absence of associated anomalies. Irrespective of cleft category, clinicians should advise invasive genetic testing if associated anomalies are seen prenatally. In the absence of associated anomalies, prenatal conventional karyotyping is not recommended in CL, although array comparative genomic hybridisation should be considered. In presumed isolated CLP or CP, prenatal invasive testing, preferably by array based methods, is recommended.

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Section: Methodsmentioning

confidence: 99%

A systematic review of associated structural and chromosomal defects in oral clefts: when is prenatal genetic analysis indicated?

et al. 2012

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“…A peculiar characteristic of the register is that it does not allow for updates later than 24 h after creating a patient record, which may preclude it from containing complete information on all congenital comorbidities and/or genetic disorders. In-depth information on the register is found in the overview by Luijsterburg and Vermeij-Keers (7). …”

Section: Methodsmentioning

confidence: 99%

Elevated Infant Mortality Rate among Dutch Oral Cleft Cases: A Retrospective Analysis from 1997 to 2011

et al. 2014

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Objectives: First, to determine the infant mortality rate (IMR) for Dutch patients with isolated oral clefts (OC) as well as for patients with clefts seen in association with other malformations. Second, to conduct a similar analysis per cleft type: cleft lip with or without cleft palate (CP), CP (including Robin sequence). Third, to examine the underlying causes of death.Material and Methods: A retrospective review of the charts of patients with OC born in the period 1997–2011 and treated in three regional cleft centers in the Netherlands.Results: One thousand five hundred thirty patients with OC were born during the study period and treated in the cleft centers. The overall IMR for all clefts was 2.09%, significantly higher than the general Dutch IMR of 0.45%. In a subanalysis per cleft type, the IMRs were 1.22, 1.38, 2.45, and 3.62% for cleft lip, cleft lip with CP, CP, and Robin sequence, respectively. The mortality rates for isolated OC did not differ significantly from the general Dutch rate. Causes of death were congenital malformations of the heart in 40.6%, airway/lungs in 15.6%, nervous system in 15.6%, infectious disease in 12.5%, and other or unknown in 15.6%.Conclusion: The elevated IMR observed in Dutch patients with OC is almost exclusively caused by associated congenital malformations. After diagnosis of an oral cleft an in-depth medical examination and a consult by the pediatrician and clinical geneticist is imperative to instigate the appropriate medical management.

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“…The methodology by which the NVSCA registry was established is described elsewhere4 11 and is summarised here.…”

Section: Methodsmentioning

confidence: 99%

“…These teams treat virtually all surviving children with clefts who reside in the Netherlands 4 5. The annual reports of this registry show that the number of cleft patients referred to the teams has fallen since 2003 6.…”

Section: Introductionmentioning

confidence: 99%

Decreasing prevalence of oral cleft live births in the Netherlands, 1997-2006

Rozendaal

Luijsterburg

Ongkosuwito

et al. 2010

Archives of Disease in Childhood - Fetal and Neonatal Edition

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Ten Years Recording Common Oral Clefts with a New Descriptive System

Abstract: This new recording method allows adequate description of common oral clefts. Many cleft types exist within these three categories and should be differentiated, because they originate from different time frames and/or cell biological mechanisms during embryogenesis.

Cited by 48 publications

References 31 publications

A systematic review of associated structural and chromosomal defects in oral clefts: when is prenatal genetic analysis indicated?

A systematic review of associated structural and chromosomal defects in oral clefts: when is prenatal genetic analysis indicated?

Elevated Infant Mortality Rate among Dutch Oral Cleft Cases: A Retrospective Analysis from 1997 to 2011

Decreasing prevalence of oral cleft live births in the Netherlands, 1997-2006

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