Tender coconut water suppresses hepatic inflammation by activating AKT and JNK signaling pathways in an in vitro model of sepsis

Lakshmanan, Jaganathan; Zhang, Baochun; Wright, Kalen; Motameni, Amierreza T.; Jaganathan, V.; Schultz, David J.; Klinge, Carolyn M.

doi:10.1016/j.jff.2019.103637

Cited by 22 publications

(23 citation statements)

References 46 publications

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“…The latest research reavels that Mincle can sense the death of renal tubular epithelial cells that through combine with β-glucosylceramide, accelerating the inflammatory response and delaying elimination of inflammation. 18) Studies on kidney disease is the same as our research results which have shown that Mincle is highly expressed in both ischemiareperfusion and cisplatin-induced AKI models, and it is specifically expressed on M1-type macrophages. In summary, the targeted Mincle study may be a new treatment for related diseases caused by inflammatory macrophages.…”

Section: Discussionsupporting

confidence: 61%

Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury <i>via</i> Suppression of Macrophage Involved Inflammation

Tan

Yan

et al. 2021

Biological & Pharmaceutical Bulletin

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Ischemia-reperfusion injury (IRI) is the major cause of acute kidney injury (AKI). The previous studies demonstrated thatOridonin can protect kidney against IRI-induced AKI, but the underlying molecular mechanism is unclear. In this study, it showed that Oridonin significantly improved kidney damage, and inhibited the expression of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and MCP-1, as well as macrophage marker F4/80 in kidney and the secretion of inflammatory cytokins in serum of AKI mice in vivo. In addition, Oridonin also effectively reduced the expression and secretion of lipopolysaccharide (LPS)-induced inflammatory factors in macrophage cell line RAW264.7 in vitro. Notably, Oridonin strongly downregulated Mincle and AKT/nuclear factor-kappaB (NF-κB) signaling both in vivo and in vitro, and the results of cellular recovery experiments of overexpression of Mincle in macrophage suggested that Oridonin suppressed inflammatory response of macrophage through inhibiting Mincle, which may be the underlying mechanism of Oridonin improving injury in kidney of AKI mice. In summary, the above results indicated that Oridonin can protect kidney from IRI-induced inflammation and injury by inhibiting the expression of Mincle in macrophage.

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Section: Discussionsupporting

confidence: 61%

Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury <i>via</i> Suppression of Macrophage Involved Inflammation

Tan

Yan

et al. 2021

Biological & Pharmaceutical Bulletin

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“…Furthermore, Rhizopus oligosporus is the main microorganism used in the fermentation process because it produces a wide range of enzymes, such as carbohydrase, proteases, lipases, and phosphatase [65][66][67] . Nevertheless, coconut water also plays a vital role in enriching the nutritional of feed in this experiment because coconut water contains minerals, amino acids, enzymes, organic acids, fatty acids, vitamins, and a few phenolic compounds [26][27][28] . Moreover, palm sap sugar also has an essential role in increased feed quality because palm sap sugar contains minerals, vitamins, and antioxidants [33][34] .…”

Section: Effect Of Different Formulation Products On the Fatty Acid Profile Of The Dietsmentioning

confidence: 99%

“…Currently, it is essential to evaluate the supplementation of feed with natural ingredients that are cost-effective and sustainable from plant resources, without compromising the growth of cultured fish and aquafeed quality. Among these ingredients are coconut water and palm sap sugar; both contain health-friendly nutrients such as minerals, amino acids, enzymes, organic acids, fatty acids, vitamins, and phenolic compounds [26][27][28] . Water coconut has been used successfully to treat diseases in humans, such as throat infections, tapeworms, gonorrhea, digestive problems, influenza, lice, giardia, bronchitis, and cholera [29][30][31] .…”

Section: Introductionmentioning

confidence: 99%

The utilization of new products formulated from water coconut, palm sap sugar, and fungus to increase nutritional feed quality, feed efficiency, growth, and carcass of gurami sago (Osphronemus goramy Lacepède, 1801) juvenile

et al. 2021

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Background: Giant gourami (Osphronemus goramy Lacepede, 1801) has become popular aquaculture in Indonesia. However, information on the feed used is minimal. This study analyzed the change in feeding nutrition, fish growth, feed efficiency, and body-carcass using product formulated from water coconut, palm sap sugar, and fungus. Methods: A total of 2,000 ml coconut water and 1,000 ml of palm sap sugar solution were formulated. Each product formulated was added with 6 g of Aspergillus niger (called product P1), 6 g of Rhizopus oligosporus (called product P2), and 6 g of Saccharomyces cerevisiae (called product P3). Commercial feeds supplemented with P1, P2, and P3 products are designated P1, P2, and P3 diets. Commercial feed added to freshwater is called the P4 diet (placebo). Their dosage is 300 ml/kg of feed. Gurami sago juveniles (initial weight 50±2.5 g and length 13.2±0.4 cm) were stocked in triplicate nets (2×1×1 m) in a freshwater concrete pond with a stocking density of 30 fish/net, an initial feeding rate of 3% per day until study termination. Results: Our results support our hypothesis that different product formulations have a significant effect (p<0.05) on growth performance and feed efficiency. At the same time, supplementing commercial feed with varying formula products has a significant impact (p<0.05) on the fatty acid composition of the diets and carcass body of gurami sago. Conclusion: Diet P2 contains a higher concentration of fatty acids to increase body weight, feed efficiency, and the best carcass fatty acid composition than other experiments for sago gurami reared in freshwater concrete ponds.

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“…Studies have shown that in sepsis patients, HMOX1 expression was higher in non-survivors than in survivors (35). Other relevant animal experiments also support this result (36,37). Ding et al's animal experiments revealed that the expression of MAPK14 in septic mice was significantly higher than that in healthy control mice.…”

Section: Discussionmentioning

confidence: 88%

Diagnostic and Predictive Values of Ferroptosis-Related Genes in Child Sepsis

Zhang²,

Liu³

et al. 2022

Front. Immunol.

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BackgroundEarly diagnosis of sepsis in children was essential to reducing mortality. This study aimed to explore the value of ferroptosis-related genes in children with sepsis.MethodsWe screened the septic children microarray dataset from the GEO database and analyzed the ferroptosis-related differentially expressed genes (DEGs). A functional analysis of ferroptosis-related DEGs was performed. The protein–protein interaction network was used to identify hub genes. We explored the immune landscape of sepsis and controls. The value of hub genes in diagnosing sepsis was tested in the training (GSE26440) and validation sets (GSE13904), and ELISA was used to verify their diagnostic value in children with sepsis in our hospital.ResultsA total of 2,103 DEGs in GSE26440 were obtained, of which ferroptosis-related DEGs were 34. Enrichment analysis showed significant enrichment in the ferroptosis and hypoxia pathways (i.e., HIF-1 pathway). The top three genes (HMOX1, MAPK14, TLR4) were selected as hub genes. Immunological analysis suggested that 10 cell types (i.e., CD8/CD4 T cells) were lower in sepsis. Immune checkpoint-related genes CD274 (PD-L1), HAVCR2 (TIM3), and SIGLEC15 were overexpressed in sepsis. The AUROC for the diagnosis of sepsis for HMOX1 and TLR4 ranged from 0.77 to 0.81, while the AUROC of MAPK14 reached 0.935 and 0.941 in the training and validation sets. Serum ELISA results of HMOX1 and TLR4 showed no significant difference in differentiating sepsis. The AUROC of MAPK14 was 0.877. When the diagnostic threshold was 74.852 ng/ml, the sensitivity and specificity were 0.906 and 0.719, respectively.ConclusionFerroptosis-related gene MAPK14 is of considerable value in the early diagnosis of sepsis in children.

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Tender coconut water suppresses hepatic inflammation by activating AKT and JNK signaling pathways in an in vitro model of sepsis

Cited by 22 publications

References 46 publications

Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury <i>via</i> Suppression of Macrophage Involved Inflammation

Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury <i>via</i> Suppression of Macrophage Involved Inflammation

The utilization of new products formulated from water coconut, palm sap sugar, and fungus to increase nutritional feed quality, feed efficiency, growth, and carcass of gurami sago (Osphronemus goramy Lacepède, 1801) juvenile

Diagnostic and Predictive Values of Ferroptosis-Related Genes in Child Sepsis

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