Tendinopathies of the Forearm, Wrist, and Hand

Wagner, Eric R.; Gottschalk, Michael B.

doi:10.1016/j.cps.2019.02.005

Cited by 11 publications

(11 citation statements)

References 85 publications

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“…Tendonitis can cause abnormalities in the normal biological properties of tendons, such as thickening of the tendon and damage of the synovium, and the pain caused by it severely affects the daily activities of patients [7]. As the hands are the main organ for daily labor, the tendon of the hands is extremely susceptible to cumulative strain; therefore, hand tendinitis is also very common in clinical practice [8]. Local hormone injection is currently the most commonly used method of treating tendinitis, but studies have shown that local hormone injection has the risk of causing necrosis of…”

Section: Discussionmentioning

confidence: 99%

Effect of Mn₃O₄ Nanoparticles on Lipopolysaccharide-Induced Inflammatory Factors in the Human Tendon Cells and Its Mechanism

Tang

et al. 2020

International Journal of Polymer Science

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Objective. To investigate the effect of Mn3O4 nanoparticles (Mn3O4NPs) on inflammatory factors induced by lipopolysaccharide (LPS) in human tendon cells and its mechanism. Methods. The Mn3O4NPs were synthesized by a hydrothermal method. RT-qPCR was used to detect the expression levels of miRNAs related to inflammation in human tendon cells. The expression level of NLRP1 (NOD-like receptor containing pyrin domain 1) was measured by Western blotting. ELISA assay was used to measure the level of TNF-α, IL-1β, IL-4, and IL-10. The relationship between miR-181a-5p and NLRP1 was verified by dual-luciferase reporter assay. Results. Mn3O4NPs produced in this study were brown spherical particles with an average size of 7-10 nm. Mn3O4NP treatment significantly reduced the levels of TNF-α and IL-1β but increased the levels of IL-4 and IL-10 in the human tendon cells induced by LPS. In addition, Mn3O4NP treatment remarkably increased the expression level of miR-181a-5p. NLRP1 is one of the targets of miR-181a-5p, and miR-181a-5p downregulated its expression. Further study showed that Mn3O4NPs could alleviate the inflammatory response of human tendon cells induced by LPS by upregulating miR-181a-5p and thus downregulating the expression of NLRP1. Conclusion. Mn3O4NPs affect the expression of inflammatory cytokines in the human tendon cells induced by LPS by modulating the molecular axis of miR-181a-5p/NLRP1.

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Section: Discussionmentioning

confidence: 99%

Effect of Mn₃O₄ Nanoparticles on Lipopolysaccharide-Induced Inflammatory Factors in the Human Tendon Cells and Its Mechanism

Tang

et al. 2020

International Journal of Polymer Science

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“…11 A positive test will elicit pain along the radial wrist when the thumb is held into flexion across the palm and the wrist is moved into ulnar deviation by the examiner (Figure 1). 12 Eichoff 's test is very similar but requires the patient to hold their own thumb into flexion using their other fingers while deviating the wrist into ulnar deviation. 9 Pain is caused by the restricted glide of the tendons as they lie in their now narrower compartment.…”

Section: Assessmentmentioning

confidence: 99%

“…Plain radiographs are not helpful in the diagnosis of De Quervain's tenosynovitis but may help to rule out other pathologies associated with radial wrist pain. 13 Differential diagnosis for De Quervain's tenosynovitis includes: 8,10,12 • intersection syndrome • osteoarthritis of the first carpometacarpal • fractures of the scaphoid or radial styloid. Ultrasonography has been shown to be highly effective in the diagnosis and treatment planning of De Quervain's tenosynovitis 6 as well as being much more cost effective for patients.…”

Section: Assessmentmentioning

confidence: 99%

‘The side of my wrist hurts’: De Quervain’s tenosynovitis

Allbrook¹

2019

Aust J Gen Pract

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“…The diagnosis can be made with the Finkelstein test, in which pain is provoked with wrist ulnar deviation. 3,4 Plain radiography may be useful for differential diagnosis. Conservative treatment of rest, non-steroidal anti-inflammatory drugs (NSAID), and physical therapy is applied first, then there may be a need for corticosteroid injections, and in resistant cases, surgery.…”

Section: Introductionmentioning

confidence: 99%

Effects of local anesthetics (neural therapy) on pain and hand functions in patients with De Quervain tenosynovitis: A prospective randomized controlled study

Şenlikçi¹,

Odabaşı

Nazlıkul

et al. 2021

Preprint

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Objective: De Quervain tenosynovitis is the most common cause of lateral wrist pain. The diagnosis can be made with the Finkelstein test when pain is provoked with wrist ulnar deviation. Conservative treatment including rest, non-steroidal anti-inflammatory medication and physical therapy is applied first, then there may be a need for corticosteroid injections, and in resistant cases, surgery. The aim of this study was to evaluate the effectiveness of neural therapy (NT) on pain and hand functions in patients with De Quervain tenosynovitis. Methods: A total of 36 patients admitted between May 2019 and March 2020 were randomly assigned to neural therapy (NT) and control groups. Hand rest and thumb spica splint were applied to all the patients, and NT interventions to the NT group only. A visual analog scale (VAS) and the Duruöz Hand index (DHI) were used to measure pain and functionality at baseline, then at 1 and 12 months after the end of the treatment. Results: The NT and control groups both showed improvements in VAS and DHI scores at 1 and 12 months compared to baseline. The VAS scores were significantly lower at both 1 and 12 months compared to baseline in the NT group. The DHI scores were lower in the NT group at 1 month, and at 12 months there was no significant difference between the two groups. No adverse effects were seen in any patient. Conclusion: NT seems to be effective in reducing pain and improving hand functions in patients with De Quervain tenosynovitis.

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Tendinopathies of the Forearm, Wrist, and Hand

Cited by 11 publications

References 85 publications

Effect of Mn₃O₄ Nanoparticles on Lipopolysaccharide-Induced Inflammatory Factors in the Human Tendon Cells and Its Mechanism

Effect of Mn₃O₄ Nanoparticles on Lipopolysaccharide-Induced Inflammatory Factors in the Human Tendon Cells and Its Mechanism

‘The side of my wrist hurts’: De Quervain’s tenosynovitis

Effects of local anesthetics (neural therapy) on pain and hand functions in patients with De Quervain tenosynovitis: A prospective randomized controlled study

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Tendinopathies of the Forearm, Wrist, and Hand

Cited by 11 publications

References 85 publications

Effect of Mn3O4 Nanoparticles on Lipopolysaccharide-Induced Inflammatory Factors in the Human Tendon Cells and Its Mechanism

Effect of Mn3O4 Nanoparticles on Lipopolysaccharide-Induced Inflammatory Factors in the Human Tendon Cells and Its Mechanism

‘The side of my wrist hurts’: De Quervain’s tenosynovitis

Effects of local anesthetics (neural therapy) on pain and hand functions in patients with De Quervain tenosynovitis: A prospective randomized controlled study

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Product

Resources

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Effect of Mn₃O₄ Nanoparticles on Lipopolysaccharide-Induced Inflammatory Factors in the Human Tendon Cells and Its Mechanism

Effect of Mn₃O₄ Nanoparticles on Lipopolysaccharide-Induced Inflammatory Factors in the Human Tendon Cells and Its Mechanism