Tendon: Biology, Biomechanics, Repair, Growth Factors, and Evolving Treatment Options

James, Roshan; Kesturu, Girish S.; Balian, Gary; Chhabra, Arvind

doi:10.1016/j.jhsa.2007.09.007

Cited by 483 publications

(493 citation statements)

References 96 publications

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“…Initially, fibroblasts and inflammatory cells, from the tendon periphery and blood, are activated and migrate to the injury site, thus contributing to cell infiltration/ adhesion formation and constituting the extrinsic mechanism (Beredjiklian, 2003). Later, the intrinsic mechanism takes place with cells from the endotenon being activated and migrating to the injury site, where they proliferate, synthesise ECM and play a role in its reorganisation (James et al, 2008;Lin et al, 2004). Indeed, one study has shown that the healing is a biphasic pattern (Kajikawa et al, 2007).…”

Section: Composition and Healing Of Tendonsmentioning

confidence: 99%

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review

Evrova

Buschmann

2017

eCM

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To promote and support tendon healing, one viable strategy is the use or administration of growth factors at the wound/rupture site. Platelet derived growth factor-BB (PDGF-BB), together with other growth factors, is secreted by platelets after injury. PDGF-BB promotes mitogenesis and angiogenesis, which could accelerate tendon healing. Therefore, in vitro studies with PDGF-BB have been performed to determine its effect on tenocytes and tenoblasts. Moreover, accurate and sophisticated drug delivery devices, aiming for a sustained release of PDGF-BB, have been developed, either by using heparin-binding and fibrin-based matrices or different electrospinning techniques.In this review, the structure and composition, as well as the healing process of tendons, are described. Part A deals with in vitro studies. They focus on the multiple effects evoked by PDGF-BB on the cellular level. Moreover, they address strategies for the sustained delivery of PDGF-BB. Part B focuses on animal models used to test different delivery strategies for PDGF-BB, in the context of tendon reconstruction. These studies showed that dosage and timing of PDGF-BB application are the most important factors for deciding which delivery device should be applied for a specific tendon laceration.

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Section: Composition and Healing Of Tendonsmentioning

confidence: 99%

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review

Evrova

Buschmann

2017

eCM

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“…Given that tissue graft based therapies have failed to restore native tendon function, it is anticipated that the tissue-engineering arpeggio (scaffolds, cells, biologics alone or in combination) would provide a functional therapy in the years to come [1][2][3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis

et al. 2015

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractControlling the cell-substrate interactions at the bio-interface is becoming an inherent element in the design of implantable devices. Modulation of cellular adhesion in vitro, through topographical cues, is a well-documented process that offers control over subsequent cellular functions. However, it is still unclear whether surface topography can be translated into a clinically functional response in vivo at the tissue / device interface. Herein, we demonstrated that anisotropic substrates with a groove depth of ~317 nm and ~1,988 nm promoted human tenocyte alignment parallel to the underlying topography in vitro. However, the rigid poly(lactic-co-glycolic acid) substrates used in this study upregulated the expression of chondrogenic and osteogenic genes, indicating possible tenocyte trans-differentiation. Of significant importance is that none of the topographies assessed (~37 nm, ~317 nm and ~1,988 nm groove depth) induced extracellular matrix orientation parallel to the substrate orientation in a rat patellar tendon model. These data indicate that two-dimensional imprinting technologies are useful tools for in vitro cell phenotype maintenance, rather than for organised neotissue formation in vivo, should multifactorial approaches that consider both surface topography and substrate rigidity be established.

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“…In response to stress such as micro trauma, repetitive overload and oxidative stress, tendons have to undergo active repair of degeneration by either degeneration of tendon itself, inflammation of the tendon sheath or a combination of both, otherwise the tendon would weaken and rupture eventually [26,27]. Tendon repair and regeneration includes three stages: tissue inflammation, cell proliferation and remodeling [28]. Inflammation can provoke the release of growth factors and cytokines [29], which then stimulate tenocyte proliferation and collagen synthesis and improve tendon healing [30].…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Tendon Structural Integrity in Chickens using Fourier Transform-Second Harmonic Generation Imaging

Sivaguru¹

2014

Cell Dev Biol

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Degenerative changes in tendons are common in human and land-dwelling vertebrates of all species, and are associated with both age and use. Tendon rupture and inflammation are common causes of lameness in broilers and breeders at multiple ages and has become a very important issue in the poultry industry attempts to analyze tendon health have relied primarily on visual assessment. The ability to conduct meaningful experiments on causes and interventions would be much improved by a direct assay of tendon structural integrity. The objective of this study is to test whether we can use Fourier transform-second harmonic generation (FT-SHG) imaging technique to quantify the differences in collagen fiber organization and nuclei morphology between normal and injured chicken tendons. Tendon injury/degeneration was induced by rearing chickens in wire-floor pens and feeding them an oxidized fat diet. Injured tendons had greater collagen fiber degradation/degeneration; more randomly organized collagen fibers, higher cellularity and more circular-shaped nuclei than normal tendons, indicating loss of collagen tertiary structure and lateral compression in injured tendons. Therefore, analysis of collagen fiber organization and nuclear morphology using FT-SHG imaging is a potential diagnostic tool to evaluate tendon structural health and to test the effects of nutrients and intervention strategies on the structural development of tendons in chickens.

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Tendon: Biology, Biomechanics, Repair, Growth Factors, and Evolving Treatment Options

Cited by 483 publications

References 96 publications

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review

In vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review

Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis

Quantitative Analysis of Tendon Structural Integrity in Chickens using Fourier Transform-Second Harmonic Generation Imaging

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