Teneurins: Transmembrane proteins with fundamental roles in development

On the resemblance of synapse formation and CNS myelination

“…Teneurins Teneurins (ten) are transmembrane glycoproteins containing epidermal growth factor (EGF)-like repeats followed by a globular domain in their C-terminal extracellular domain, and an N-terminal cytoplasmic domain that can undergo cleavage and translocate to the nucleus to regulate gene expression (Tucker et al, 2007). This phylogenetically conserved family is present both in invertebrates and vertebrates, which strongly express all four of their teneurins in the nervous system (Tucker and Chiquet-Ehrismann, 2006).…”

C-terminal processing of the teneurin proteins: Independent actions of a teneurin C-terminal associated peptide in hippocampal cells

“…The teneurin family of proteins has recently emerged as a candidate system to integrate the origin of these disorders (Rotzinger et al, 2010). The teneurins are a recently described family of four type-II transmembrane proteins predominantly expressed in the central nervous system (CNS) (Ben-Zur et al, 2000;Levine et al, 1994;Tucker et al, 2007) and are implicated in visual, auditory and olfactory integration in the CNS (Kenzelmann et al, , 2008Leamey et al, 2007Leamey et al, , 2008Rubin et al, 2002;Wang et al, 2005;Young and Leamey, 2009). Moreover, they are highly conserved in metazoans indicating that they may play a fundamental role in the evolution of sensorimotor integration (Tucker et al, 2012).…”

International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

“…4E). Interestingly, all three distinct interacting partners of the latrophilinsteneurins, FLRTs, and neurexins-are single-span transmembrane molecules that have roles in axon guidance, neuronal connectivity, and synapse formation (Lise and El-Husseini, 2006;Tucker et al, 2007;Bottos et al, 2011;O'Sullivan et al, 2012). This suggests that latrophilins have a general role in recognizing transmembranous molecules involved in neuronal biology and may function to signal during neuronal development mediated via interactions with these binding partners.…”