Global systems of capitalist production shape local experiences with health and disease, as well as approaches to infectious disease control. Through participants’ descriptions of health-disease experiences, I explore an alternate route for the prevention and control of mosquito-borne diseases in Tegucigalpa, Honduras, beyond a strict focus on vector control. I identify three local enunciations of health-disease processes through the experiences of five different stakeholders. These local enunciations demonstrate a nuanced understanding of health-disease processes and are indicative of unfulfilled local needs and aspirations. Importantly, these local enunciations point to different experiences of dispossession (e.g., material, political, subjective) under neoliberal regimes.