Tensile Strength of Biological Fibrin Sealants: A Comparative Study

Lacaze, L.; Dem, Nicolas Le; Bubenheim, Michael; Tsilividis, Basile; Mezghani, Julien; Schwartz, Lilian; François, Arnaud; Ertaud, Jean-Yves; d'Arc, Maurice Bagot; Scotté, Michel

doi:10.1016/j.jss.2011.11.1017

Cited by 14 publications

(18 citation statements)

References 16 publications

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“…Using a canine model of liver resection, comparisons of fibrin sealant adhesion strength were performed [97] which determined that Tisseel (mean 775, range 491–1224 mN/m 2 ) had higher adhesion strength than Quixil (mean 246, range 148–409 mN/m 2 ) ( P < 0.002) or Beriplast (mean 242, range 153–384 mN/m 2 ) ( P < 0.001) and that Tachosil (mean 596, range 373–954 mN/m 2 ) had higher adhesion strength than Quixil ( P < 0.014) or Beriplast ( P < 0.009). The authors suggest that the differences in adhesion strength may be influenced by the amounts of fibrinogen, thrombin, factor XIII, and collagen present in each product.…”

Section: Fibrin Sealant Laboratory Literaturementioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

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Section: Fibrin Sealant Laboratory Literaturementioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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“…The positive hemostatic effects of sealants have been confirmed repeatedly and advantages include their availability, hemostatic efficacy, mechanical properties, wound healing effects, and cellular response . From the clinical point of view, an optimal adhesive should be biocompatible and biodegradable without inducing inflammation, foreign body reactions, tissue necrosis, or fibrosis . Furthermore, it should act locally, be safe, and not disrupt natural healing …”

Section: Discussionmentioning

confidence: 99%

Hemostatic efficiency of modern topical sealants: Comparative evaluation after liver resection and splenic laceration in a swine model

et al. 2017

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Parenchymal transection during hepatobiliary surgery can disrupt small vasculature or bile ducts, which could be managed difficultly. Sealants are helpful tools to achieve better hemostasis. The aim of this study is to analyze the hemostatic efficiency of four modern sealants in a porcine model. In this study, 40 landrace pigs were assigned equally to the control (without sealant) and four sealant groups. Standardized liver resection and splenic lesions were performed and left without using sealant (control) or treated with one of the following sealants: TachoSil , Tissucol Duo , Coseal , and FloSeal . We measured relative and absolute bleeding times (seconds) as well as total blood loss (g) in a maximum observation time of 300 s. Sealants could show a significantly improved hemostasis comparing to the control group. However, hemostasis was heterogeneous among the sealant groups (liver resection: 60%-100%, spleen injury: 70%-100%). The mean blood loss decreased significantly using sealants comparing to control group (liver resection: 6-120 fold, spleen injury: 2.5-36 fold). The hemostatic time in groups that achieved complete hemostasis was different in each sealant group (liver resection: 30-166 s, spleen injury: 60-180 s). We conclude that the hemostatic efficacy of modern sealants is impressive but heterogeneous in liver resection or splenic lesion. To maximize the effectiveness of these tools, the indication of each sealant should be carefully considered in individual settings by the surgeons. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1307-1316, 2018.

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“…The adhesive properties of fibrin glue preparations are used to classify the products and are often evaluated via tensile testing [1,[5][6][7]. Tensile testing of fibrin glue has been reported using vital human tissue [6], rat or pig skin and canine or rat models [7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Tensile testing of fibrin glue has been reported using vital human tissue [6], rat or pig skin and canine or rat models [7]. The adhesive strength of commercial sealants tested in animal models was reported at 0.0242-0.0775 mN/cm 2 with maximum forces of 300-1000 mN [7]. Testing with human tissue reached an adhesive strength of 811.1 mN/cm 2 [6] using commercial fibrin sealant and 531.2 mN/cm 2 using the autologous Vivostat® System [6].…”

Section: Introductionmentioning

confidence: 99%

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Autologous fibrin glue: automated production and adhesive quality

Düregger

Frenzel

Eblenkamp

2017

Current Directions in Biomedical Engineering

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Fibrin glue is a two-component adhesive used to stop bleeding, seal wound edges and for scaffolds in tissue engineering. Autologous products result in reduced risk of contamination and immunological responses compared to commercially available fibrin glue. However, reproducibility due to patient dependent sealant properties of autologous fibrin glue preparation is low. In this study a fully automated production process for both the fibrinogen and thrombin component from small blood volumes was developed. The resulting fibrinogen concentration, thrombin activity and sealant properties of the fibrin glue were determined. The fully automated and closed production system proved to be a promising tool for fast and easy production of autologous fibrin glue with an effective adhesive quality.

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Tensile Strength of Biological Fibrin Sealants: A Comparative Study

Cited by 14 publications

References 16 publications

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Hemostatic efficiency of modern topical sealants: Comparative evaluation after liver resection and splenic laceration in a swine model

Autologous fibrin glue: automated production and adhesive quality

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