Tensiometric, fluorescence and  1 H NMR study of mixed micellization of non-steroidal anti-inflammatory drug sodium salt of ibuprofen in the presence of non-ionic surfactant in aqueous/urea solutions

Rub, Malik Abdul; Khan, Farah; Sheikh, Mohmad Shafi; Azum, Naved; Asiri, Abdullah M.

doi:10.1016/j.jct.2016.01.001

Cited by 136 publications

(39 citation statements)

References 58 publications

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“…Indeed, measurement of solubilization kinetics of IBP in 0.5 wt% solution of Tween showed that drug the solubility increases very quickly: μg/mL for min, compared to the equilibrium solubility of 890 μg/mL. The formation of mixed micelles between IBP and surfactants is supported also by Rub et al [38], who studied in detail the properties of these drugsurfactant micelles. Therefore, we can expect that IBP will have very high solubilization rate in the presence of surfactants, even in the acidic medium of the stomach which should significantly shorten the plasma tmax values and improve the oral bioavailability.…”

Section: Mole Fraction and Energy Of Incorporation Of Ibp In The Mixementioning

confidence: 85%

Improving Ibuprofen solubility by surfactant-facilitated self-assembly into mixed micelles

Stoyanova

Vinarov

Tcholakova

2016

Journal of Drug Delivery Science and Technology

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Ibuprofen is a poorly water-soluble drug, characterized by dissolution-limited oral bioavailability. One approach to improve its water solubility and bioavailability is by solubilizing it in micellar surfactant solutions. Here we investigate the effect of the surfactant type and the mechanism of solubility enhancement of Ibuprofen in surfactant solutions. The equilibrium Ibuprofen solubility in solutions of six surfactants was determined by HPLC. The nonionic surfactant polysorbate 80 (Tween 80), and the anionic surfactants sodium dodecyl sulfate (SDS) and sodium lauryl ethoxy (3) sulfate (SLES-3EO) improve the Ibuprofen solubility by a factor of 200, as compared to the solubility in water. The highest Ibuprofen solubility is observed in SDS and SLES-3EO solutions, containing 0.6 M NaCl. The mole fraction of Ibuprofen in the micelles and the transfer energy of Ibuprofen molecules from the aqueous phase into the micelle environment were determined by thermodynamic analysis of the solubility data. The maximum Ibuprofen mole fraction in the micelles of all studied surfactants is exceptionally high (between 0.4 and 0.6). Thus we can conclude that the main mechanism of Ibuprofen solubility enhancement is a selfassembly within mixed micelles with the main surfactant. The energy of co-micellization is estimated to be around 14kT per Ibuprofen molecule.

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Section: Mole Fraction and Energy Of Incorporation Of Ibp In The Mixementioning

confidence: 85%

Improving Ibuprofen solubility by surfactant-facilitated self-assembly into mixed micelles

Stoyanova

Vinarov

Tcholakova

2016

Journal of Drug Delivery Science and Technology

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“…Surfactants are useful as they have aggregated structures called micelles. These compounds are best known as detergent in surface water and the foam producing layer on the ocean surface (Rub et al, 2016;Kumar et al 2015). Sea surface microlayer and soots from combustion activities are also responsible for the surfactant in the atmospheric environment.…”

Section: Introductionmentioning

confidence: 99%

Determination and analysis of trace metals and surfactant in air particulate matter during biomass burning haze episode in Malaysia

Ahmed

Guo

Xin

2016

Atmospheric Environment

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“…Therefore, a plot of γ versus log c reduces steeply up to the cmc and becomes relatively constant above it. The tensiometric method is more sensitive (by detecting small micellar aggregates) and also demonstrates the onset of micelle formation in the amphiphilic solution (Rub et al, ). In our study, the CMC value obtained from surface tension is lower than the value obtained from conductivity measurements for pure cationic Gemini surfactant at 298.15 K. Five different inorganic salts (LiCl, KCl, NaCl, KBr, and KNO 3 ) were used to determine the effect of the surface properties of mixed systems.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Mixing Behavior of both a Conventional Surfactant and Different Inorganic Salts with a Cationic Gemini Surfactant in Aqueous Solution

Sarıkaya

Bilgen

Akbaş

2019

J Surfact & Detergents

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N,N′‐bis [3‐(dodecanoylamino)propyl]‐N,N,N′,N′‐tetramethylhexane‐1,6‐diaminium dibromide is a cationic Gemini surfactant including quaternary ammonium salt with amide groups. Critical micelle concentration (CMC) and some thermodynamic parameters of the cationic Gemini surfactant were investigated using surface tension and conductivity methods. Mixed micellization of binary mixtures of the cationic Gemini surfactant with a conventional surfactant cetyl trimethylammonium bromide (CTAB) was investigated using the conductometric method at five different temperatures ranging from 303.15 to 323.15 K. CMC, micellar ionization degree (αm), counterion binding constant (g1), interaction parameter (β), and activity coefficients (f1M and f2M) of mixed systems were found out from data of conductivity at different mole fractions for all studied temperatures. Additionally, the effects of some inorganic salts with different concentrations on the surface properties of cationic Gemini surfactant were examined by surface tension measurements. Some surface properties of the pure cationic Gemini surfactant and mixed salts systems were calculated using the data of surface tension.

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Tensiometric, fluorescence and 1 H NMR study of mixed micellization of non-steroidal anti-inflammatory drug sodium salt of ibuprofen in the presence of non-ionic surfactant in aqueous/urea solutions

Cited by 136 publications

References 58 publications

Improving Ibuprofen solubility by surfactant-facilitated self-assembly into mixed micelles

Improving Ibuprofen solubility by surfactant-facilitated self-assembly into mixed micelles

Determination and analysis of trace metals and surfactant in air particulate matter during biomass burning haze episode in Malaysia

Investigation of Mixing Behavior of both a Conventional Surfactant and Different Inorganic Salts with a Cationic Gemini Surfactant in Aqueous Solution

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