The aim of this paper is to present and discuss certain fundamental biographical and theoretical aspects in the proposal and development of Fernando González Rey’s Theory of Subjectivity. Thus, it highlights his early participation in the Cuban Revolution, the first advances in his studies (1968–73), his concern surrounding the study of Personality (1973–97) and, finally, his development of the Theory of Subjectivity and Qualitative Epistemology (1997–2019). We specifically highlight the critical dialogue with cultural-historical psychology, especially with L. Bozhovich and L. Vygotsky. We also outline his main theoretical concepts related to the Theory of Subjectivity. Finally, his Theory of Subjectivity is analysed as a complex ‘macro-theory’, with a critical and subversive vocation, open to the generation of new spaces of intelligibility that facilitate the study of the creative and generative character of human phenomena.