Terahertz spectroscopy of DNA

Tsurkan, Mikhail V.; Balbekin, Nikolay S.; Sobakinskaya, E. A.; Панин, А. Н.; Вакс, В. Л.

doi:10.1134/s0030400x13060222

Cited by 23 publications

(16 citation statements)

References 15 publications

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“…Both stimulating and inhibiting effects of the action of THz radiation at various levels of biological organization 3,5 have been noted from the results of the studies. Therefore, it is necessary to determine the biologically safe levels of THz radiation that can be used in systems of THz spectroscopy and simultaneously to eliminate the appearance of any primary biological effects, as was done earlier with other ranges of radiation.…”

Section: Introductionmentioning

confidence: 98%

“…1 The THz region covers the spectral range of vibrational, rotational, and translational lines of a broad class of organic and biological molecules. 2,3 When images are formed with pulsed broad-band THz radiation, it is possible to obtain a resolution as good as 100 μm with a high SNR because there is little Rayleigh scattering of radiation in this range. 4 In this connection, THz diagnosis is extremely promising, since the radiation-penetration depth is significantly greater than that obtained with optical coherent tomography.…”

Section: Introductionmentioning

confidence: 99%

“…7,8 It was shown with the same stain that radiation at a frequency close to 2.31 THz can cause reversible damage of the barrier properties of the neuron membranes. 3 In experiments with human skin fibroblasts under the action of THz radiation with a frequency of 2.52 THz (227 mW∕cm 2 , more than 12 s), the effect of an increase of the permeability of the cell membrane is noted by using stains.…”

Section: Introductionmentioning

confidence: 99%

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Study of the action of broad-band terahertz radiation on the functional activity of cells

et al. 2013

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In order to determine the limits of the biologically safe maximum allowable levels of pulsed terahertz (THz) radiation, a prototype of apparatus has been developed for the irradiation of cell cultures immersed in a liquid medium with broad-band THz radiation in the 0.05-1.2 THz frequency range. The action of THz radiation on the functional activity of the cells of a number of biological cultures, including mouse thymocytes and splenocytes, has been investigated. This was evaluated by means of flow-through cytometry, using fluorescence-intensity analysis of DNAbinding stains. It is shown that THz radiation with a mean power density of up to 10 μW∕cm 2 and a time of action of 1 min has no effect on the variation of the functional activity of the cells. No statistically reliable variations were detected in the relationship of living cells and cells at different stages of apoptosis or in the distribution of cells over the phases of the cellular cycle. It is concluded that THz radiation with such characteristics can be used for medical spectroscopy.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Study of the action of broad-band terahertz radiation on the functional activity of cells

et al. 2013

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“…The application of these technologies has led to many promising applications with a strong future potential [1][2][3][4][5]. THz-TDS and THz-I techniques have been employed in applications that extract information from materials that cannot be obtained by using other techniques; this was achieved by analyzing their interaction with terahertz electromagnetic fields [6][7][8][9]. Although there exists a broad variety of commercial systems and applications for THz-TDS and THz-I, there are many challenges to be solved in the current state-of-the-art terahertz technology.…”

Section: Introductionmentioning

confidence: 99%

Time-domain numerical modeling of terahertz receivers based on photoconductive antennas

et al. 2015

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We present here a simulator that solves the main semiconductor charge and transport equations coupled to Maxwell equations to study receivers based on photoconductive antennas (R-PCAs). Making use of this tool we were able to correctly characterize the operation of these antennas. In doing so, we compared simulations with the results of the semi-empirical expression I THz t ∝ σ c t E THz t employed to evaluate the detected photocurrent by means of the convolution between the photoconductivity in the receiver and the electric field linked to the emitter antenna. We were able to accurately reproduce experimental data with our simulation tool. These kinds of tools are essential to model photoconductive antennas, a fundamental step needed for the development of terahertz time-domain spectroscopy applications based on PCAs.

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“…This interest is caused by the high application potential of THz radiation in medical diagnostics, remote sensing, and spectroscopy of chemical and biological objects. These prospects are based on the fact that the THz range includes a large part of the vibrational-rotational spectra of water and many organic molecules, including biologically active macromolecules (proteins and nucleic acids), as well as frequencies of intermolecular interaction [1,2].…”

Section: Introductionmentioning

confidence: 99%

Stimulation of neurite growth under broadband pulsed THz radiation

2014

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The effect of low-intensity broadband pulsed THz radiation in the range from 0.05 to 1.2 THz, with power from 0.25 to 11.6 μW, on the growth of neurites of spinal ganglia of (10−12)-day chick embryos has been investigated. An analysis of the 3-min irradiation with powers in this range has demonstrated both stimulating and suppressive effects of THz radiation on the proliferative activity of neurites. This effect manifests itself with a decrease in the THz radiation power.

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Terahertz spectroscopy of DNA

Cited by 23 publications

References 15 publications

Study of the action of broad-band terahertz radiation on the functional activity of cells

Study of the action of broad-band terahertz radiation on the functional activity of cells

Time-domain numerical modeling of terahertz receivers based on photoconductive antennas

Stimulation of neurite growth under broadband pulsed THz radiation

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