Despite advances in treatment and campaigns for prevention and control of malaria on
the various continents where it is still rampant, this disease remains significantly
relevant to the contemporary world. Plasmodium falciparum is the
organism that is mainly responsible for severe malaria, which is characterized by
disturbances in different organs and systems, with possibly fatal outcomes. Although
incipient, proteomic studies of malaria have yielded favorable prospects for
elucidating the biological aspects of Plasmodium as well as the
pathophysiological, diagnostic, prophylactic, and therapeutic mechanisms of the
disease. Thus, the aim of the present article is to present a brief review of the
applications of proteomic analysis in P. falciparum malaria.