Teratogenic and anti-metamorphic effects of bisphenol A on embryonic and larval Xenopus laevis

Iwamuro, Shawichi; Sakakibara, Michiaki; Terao, Megumi; Ozawa, Akiko; Kurobe, Chizuko; Shigeura, Tomokuni; Kato, Mayuko; Kikuyama, Sakaé

doi:10.1016/s0016-6480(03)00188-6

Cited by 108 publications

(58 citation statements)

References 42 publications

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“…However, a positive correlation between increasing BPA and activity of UDPGT was found -UDPGT catalyzes the conjugation of various substances to glucuronic acid, and an increasing activity may lead to faster metabolism of THs. BPA blocked T3-induced resorption of tail segments in larvae in vitro and decelerated T4-induced metamorphic changes of tadpoles in vivo (69). BPA fed to pregnant rats was associated with significant increase of TT4 at postnatal day 15 in the pups (70).…”

Section: Flame Retardantsmentioning

confidence: 81%

Environmental chemicals and thyroid function

Boas¹,

Feldt‐Rasmussen

Skakkebæk³

et al. 2006

eur j endocrinol

462

290

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There is growing evidence that environmental chemicals can disrupt endocrine systems. Most evidence originates from studies on reproductive organs. However, there is also suspicion that thyroid homeostasis may be disrupted. Several groups of chemicals have potential for thyroid disruption. There is substantial evidence that polychlorinated biphenyls, dioxins and furans cause hypothyroidism in exposed animals and that environmentally occurring doses affect human thyroid homeostasis. Similarly, flame retardants reduce peripheral thyroid hormone (TH) levels in rodents, but human studies are scarce. Studies also indicate thyroid-disruptive properties of phthalates, but the effect of certain phthalates seems to be stimulative on TH production, contrary to most other groups of chemicals. Thyroid disruption may be caused by a variety of mechanisms, as different chemicals interfere with the hypothalamic -pituitary -thyroid axis at different levels. Mechanisms of action may involve the sodium-iodide symporter, thyroid peroxidase enzyme, receptors for THs or TSH, transport proteins or cellular uptake mechanisms. The peripheral metabolism of the THs can be affected through effects on iodothyronine deiodinases or hepatic enzymes. Even small changes in thyroid homeostasis may adversely affect human health, and especially fetal neurological development may be vulnerable. It is therefore urgent to clarify whether the animal data showing effects of chemicals on thyroid function can be extended to humans. European Journal of Endocrinology 154 599-611

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Section: Flame Retardantsmentioning

confidence: 81%

Environmental chemicals and thyroid function

Boas¹,

Feldt‐Rasmussen

Skakkebæk³

et al. 2006

eur j endocrinol

462

290

View full text Add to dashboard Cite

show abstract

“…Iwamuro 129 first reported that BPA could block thyroid hormone-induced tail resorption during Xenopus metamorphosis. This report was followed by a study using primary mouse Oligodendrocyte Precursor Cells (OPCs) finding that 10 -5 M BPA could inhibit T3-induced specification of oligodendrocytes.…”

Section: Bisphenol-amentioning

confidence: 99%

Environmental chemicals targeting thyroid

Zoeller¹

2010

133

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Thyroid hormones (THs) are required for normal brain and somatic development and for the proper regulation of physiology in both children and adults. Thyroid function is controlled by the dynamic interrelationships between the hypothalamus, the pituitary and the thyroid. These dynamic relationships maintain circulating levels of THs within a narrow range under normal conditions. Normally, there is likely to be a tight relationship between changes in circulating levels of THs and changes in TH action in various target tissues. This relationship is maintained by tissue-level mechanisms that include TH metabolism and transport. Environmental chemicals that interfere with TH signaling mechanisms (Endocrine Disrupting chemicals, EDcs) may produce adverse effects both in the individual and in a population. Because of the complex nature of the regulation of thyroid function and TH action, the consequences of EDc exposure is also likely to be complex and our ability to understand these effects as well as to screen for potential EDcs must consider this complexity. Specifically, if there are chemicals in the environment that directly interfere with TH action through their receptors but do not affect circulating TH levels, they would not be identified as thyroid toxicants by currently applied screening methods or by epidemiological studies. The goal of this review is therefore to identify the issues that must be clearly resolved before effective risk assessment can be performed. HORMONES 2010, 9(1) the hypothalamic pituitaRy thyRoid axis (hpt) axis To develop efficient risk assessment strategies for thyroid toxicants, it is important to understand both the normal functioning of the hypothalamic-pituitary-thyroid axis (HPT) and what we know about individual thyroid toxicants. To this end, background information about the HPT axis and its relevance to thyroid toxicology is reviewed here. Key words: Thyroid hormones, Endocrine disruptors, Environmental chemicals, Thyroid toxicants ReviewCirculating levels of Thyroid Hormones (THs) are maintained within a relatively narrow range 1 in large part by a negative feedback relationship between circulating levels of THs and those of Thyroid Stimulating Hormone (TSH). THs appear to exert this effect by acting on one subtype of the TH receptor (TR). TRs are encoded by two separate genes,  and , the primary transcripts of which are alternatively spliced

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“…BPA has been found to antagonize thyroid hormone (TH) action in vitro and in vivo assays. 5,6) The brominated BPA analogue, tetrabromobisphenol A (TBBPA), is widely used as a flame retardant in building materials, paints, etc., 7) and has been reported to be weakly estrogenic in vitro, [8][9][10] to bind thyroid hormone receptor (TR) in vitro, 11,12) and to antagonize the biological function of TH in vivo. 12) TBBPA inhibits larval development in Xenopus laevis (X. laevis).…”

Section: Introductionmentioning

confidence: 99%