Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats.: I. Reproductive Damage

Abstract

ARTEAGA-MARTÍNEZ, M.; GARCÍA-PELÁEZ, I.; AGUIRRE-LUNA, O. M. & SAAVEDRA-ONTIVEROS, D. Teratogenic effect of ethylene glycol-methyl cellosolve mixture in rats. I. Reproductive damage. Int. J. Morphol., 28(4):1087-1092, 2010. SUMMARY:We investigated the reproductive damage and teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, which received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing reproductive damage, external fetal abnormalities, growth delay, and increased fetal death. ARTEAGA-MARTÍNEZ, M.; GARCÍA-PELÁEZ, I.; AGUIRRE-LUNA, O. M. & SAAVEDRA-ONTIVEROS, D. Teratogénesis por etilenglicol-metilcelosolve en ratas. I. Daño reproductivo. Int. J. Morphol., 28(4):1087-1092, 2010.RESUMEN: Se investigó el daño reproductivo y efecto teratogénico de una mezcla de etilenglicol y metilcelosolve en ratas gestantes, las cuales recibieron por vía intraperitoneal una dosis diaria, a diferentes concentraciones de la mezcla, del día 8 al día 20 de gestación. En las ratas tratadas con la mezcla el número de fetos vivos disminuyó y las reabsorciones y el número de fetos anormales aumentaron a mayor concentración de los solventes. Concluimos que la mezcla de etilenglicol-metilcelosolve tiene mayor efecto teratogénico que cuando actúan cada uno de los solventes por separado, produciendo daño reproductivo, anormalidades fetales externas, retraso del crecimiento y aumento de muerte fetal. ARTEAGA-MARTÍNEZ, M.; GARCÍA-PELÁEZ, I.; AGUIRRE-LUNA, O. M. & SAAVEDRA-ONTIVEROS, D. Teratogenic effect of ethylene glycol-methyl cellosolve mixture in rats. I. Reproductive damage. Int. J. Morphol., 28(4):1087-1092, 2010.

Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations

“…Many pesticides have anti-androgenic activity, and a strong association has been found between pesticides and hypospadias (10, 25). Prenatal exposure to ethylene glycol-methyl cellosolve can lead to reproductive damage, congenital birth defects, intrauterine growth restriction and death (163). Perinatal exposure to toluene can reduce serum testosterone in preand post-pubertal rats (164).…”