Teratogenic effects of suramin on the chick embryo

Männer, Jörg; Seidl, W; Heinicke, Franziska; Hesse, Hagen

doi:10.1007/s00429-002-0292-3

Cited by 21 publications

(17 citation statements)

References 79 publications

(81 reference statements)

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“…(46)(47)(48)(49)(50)(51) Several prescription drugs, including calcium valproate, acetazolamide, suramin and flubendazole, have also been found to cause body-wallrelated abnormalities in rodents and avians. (52)(53)(54)(55) Given that these substances cause embryotoxicity in rodents and/or chickens, the same birth defects have been inferred in pregnant women. Clearly, however, rodent, avian and human embryos may not be affected in equivalent ways by the same environmental agent.…”

Section: Normal Development Of the Ventral Body Wall In Humansmentioning

confidence: 89%

Finally, a sense of closure? Animal models of human ventral body wall defects

2004

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Malformations concerning the ventral body wall constitute one of the leading categories of human birth defects and are present in about one out of every 2000 live births. Although the occurrence of these defects is relatively common, few detailed experimental studies exist on the development and closure of the ventral body wall in mouse and human. This field is further complicated by the array of theories on the pathogenesis of body wall defects and the likelihood that there is no single cause for these abnormalities. In this review, we summarize what is known concerning the mechanisms of normal ventral body wall closure in humans and mice. We then outline the theories that have been proposed concerning human body wall closure abnormalities and examine the growing number of mouse mutations that impact normal ventral body wall closure. Finally, we speculate how studies in animal models such as mouse and Drosophila are beginning to provide a much-needed mechanistic framework with which to identify and characterize the genes and tissues required for this vital aspect of human embryogenesis.

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Section: Normal Development Of the Ventral Body Wall In Humansmentioning

confidence: 89%

Finally, a sense of closure? Animal models of human ventral body wall defects

2004

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“…Data on experimentallyinduced holoprosencephaly in the golden hamster even suggest that alterations in selected proteins in the prechordal mesoderm and adjacent floor plate, impair the adjacent neural plate and neural crest and, thus, induce these anomalies (Coventry et al 1998). Similarly, the anticancer agent suramin was found to cause midfacial defects in chicken (Männer et al 2003).…”

Section: Part IIImentioning

confidence: 97%

A re-evaluation of the premaxillary bone in humans

Barteczko

Jacob

2004

Anatomy and Embryology

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The discovery of the premaxillary bone (os incisivum, os intermaxillare or premaxilla) in humans has been attributed to Goethe, and it has also been named os Goethei. However, Broussonet (1779) and Vicq d'Azyr (1780) came to the same result with different methods. The first anatomists described this medial part of the upper jaw as a separate bone in the vertebrate skull, and, as we know, Coiter (1573) was the first to present an illustration of the sutura incisiva in the human. This fact, and furthermore its development from three parts:-(1) the alveolar part with the facial process, (2) the palatine process, and (3) the processus Stenonianus-can no longer be found in modern textbooks of developmental biology. At the end of the nineteenth and in the early twentieth century a vehement discussion focused on the number and position of its ossification centers and its sutures. Therefore, it is hard to believe that the elaborate work of the old embryologists is ignored and that the existence of a premaxillary bone in humans is even denied by many authors. Therefore this re-evaluation was done to demonstrate the early development of the premaxillary bone using the reconstructions of Felber (1919), Jarmer (1922) and data from our own observations on SEM micrographs and serial sections from 16 mm embryo to 68 mm fetus. Ossification of a separate premaxilla was first observed in a 16 mm embryo. We agree with Jarmer (1922), Peter (1924), and Shepherd and McCarthy (1955) that it develops from three anlagen, which are, however, not fully separated. The predominant sutura incisiva (rudimentarily seen on the facial side in a prematurely born child) and a shorter sutura intraincisiva argue in this sense. The later growth of this bone and its processes establish an important structure in the middle of the facial skull. Its architecture fits well with the functional test of others. We also focused on the relation of the developing premaxilla to the forming nasal septum moving from ventral to dorsal and the intercalation of the vomer. Thus the premaxilla acts as a stabilizing element within the facial skeleton comparable with the keystone of a Roman arch. Furthermore, the significance of the premaxillary anlage for the closure of the palatine was documented by a synopsis made from a stage 16, 10.2 mm GL embryo to a 49 mm GL fetus. Finally the growth of the premaxilla is closely related to the development of the human face. Abnormal growth may be correlated to characteristic malformations such as protrusion, closed bite and prognathism. Concerning the relation of the premaxillary bone to cleft lip and palate we agree with others that the position of the clefts is not always identical with the incisive suture. This is proved by the double anlagen of an upper-outer incisor in a 55 mm fetus and an adult.

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“…Secondly, among these suramin-treated embryos the open defects occurred with an incidence of 8%, which corresponded to the incidences of cloacal exstrophy found in previous studies on suramin-treated chicks on the 8th incubation day (4-7%; Ma¨nner and Kluth 2003;Ma¨nner et al 2003). Thirdly, the body wall defects open into the embryonic cloaca and allantois (Fig.…”

Section: Discussionmentioning

confidence: 86%

“…first, these open defects in the infra-umbilical body wall occurred in a small proportion of young chick embryos that had been treated with the drug suramin according to established protocols, which had been proven to induce cloacal exstrophy in chicks (Ma¨nner and Kluth 2003;Ma¨nner et al 2003). Secondly, among these suramin-treated embryos the open defects occurred with an incidence of 8%, which corresponded to the incidences of cloacal exstrophy found in previous studies on suramin-treated chicks on the 8th incubation day (4-7%; Ma¨nner and Kluth 2003;Ma¨nner et al 2003).…”

Section: Discussionmentioning

confidence: 99%

The morphogenesis of the exstrophy-epispadias complex: a new concept based on observations made in early embryonic cases of cloacal exstrophy

Männer

Kluth

2005

Anat Embryol

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Besides the presence of an abnormal opening into the cloaca, all embryos were characterised by an abnormal broadening of the caudal trunk at the level of the leg buds, which, in the youngest embryos, was associated with the abnormal presence of large aneurysmatic swellings of the dorsal aortae at this side. We postulate that these aneurysmatic swellings might be the primary defects leading to the development of EEC malformations. These space-occupying anomalies seem to cause abnormal distensions of the developing pelvis and of the infra-umbilical portion of the developing body wall. In consequence, the mid-portion of the developing ventral body wall between the origin of the umbilical cord and the cloacal plate becomes stretched and thinned out. Tension and thinning of the ventral body wall might ultimately lead to its rupture with exposure of the lumen of the embryonic cloaca and allantois. This new concept on the morphogenesis of the EEC is the first not to be inferred from the conditions seen in fetal or postnatal human cases but is based entirely on data from malformed embryos.

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Teratogenic effects of suramin on the chick embryo

Cited by 21 publications

References 79 publications

Finally, a sense of closure? Animal models of human ventral body wall defects

Finally, a sense of closure? Animal models of human ventral body wall defects

A re-evaluation of the premaxillary bone in humans

The morphogenesis of the exstrophy-epispadias complex: a new concept based on observations made in early embryonic cases of cloacal exstrophy

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