Teratologic studies of carbaryl, diazinon, norea, disulfiram, and thiram in small laboratory animals

Robens, Jane F.

doi:10.1016/0041-008x(69)90143-4

Cited by 131 publications

(30 citation statements)

References 4 publications

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“…The ED lo for malformations was 7.1 nmol/egg for TMTD, 27 nmol/egg for TMTM, and 46 nmollegg for TETD. In a mammalian study TMTD has been shown to be more potent than TETD, which has been active only when administered in dimethylsulfoxide (4).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Application of the chicken embryo in testing for embryotoxicity: thiurams.

Korhonen¹,

Hemminki²,

Vainio³

1982

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 99%

“…TMTD has been found to be a teratogen in mice (5) and hamsters (4). TETD has also caused malformations in hamsters but only when introduced in dimethylsulfoxide (4).…”

mentioning

confidence: 99%

Application of the chicken embryo in testing for embryotoxicity: thiurams.

Korhonen¹,

Hemminki²,

Vainio³

1982

Scand J Work Environ Health

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“…A., 2001). Embryonic exposure to thiram and similar other DTC induce a variety of skeletal, and craniofacial abnormalities (Van Leeuwen et al, 1990;Robens 1969;van Boxtel et al, 2010;Teraoka et al, 2006;Suzuki et al, 2000;Tilton et al, 2006;Haendel et al, 2004). In post hatch poultry thiram produces tibial dyschondroplasia (TD), a common leg problem, where the proximal growth plate cartilage of tibia and tibiotarsal bones fail to undergo endochondral bone formation (Vargas et al, 1983;Rath et al, 2007;Leach and Monsonego-Ornan, 2007;Pines et al, 2005;Simsa et al, 2007;Orth and Cook, 1994;Farquharson, 2002).…”

Section: Introductionmentioning

confidence: 99%

Effect of thiram on avian growth plate chondrocytes in culture

Rasaputra

Liyanage²,

Lay³

et al. 2013

J. Toxicol. Sci.

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-Thiram is a dithiocarbamate pesticide that causes tibial dyschondroplasia (TD), a growth plate defect, in poultry. Deaths of transitional zone chondrocytes appear to interrupt endochondral bone development leading to the broadening of growth plate. The mechanism of action of thiram on chondrocytes is not well understood. Since proteins play major roles in different aspects of cell's metabolism, growth, and survival, the objective of this study was to find whether thiram produces proteomic changes that could impair the development of chondrocytes. The chondrocytes, isolated from proximal tibial growth plates, were cultured with or without a sub-lethal concentration of thiram for 48 hr, and the cell proteins were extracted, and subjected to 2-D gel electrophoresis. The gel images were compared and statistically evaluated using Melanie software to identify differentially expressed protein spots. Of a total of 72 identifiable spots 3 were down-regulated and 2 up-regulated in thiram treated chondrocytes. In-gel trypsin digestion of the protein spots followed by their characterization by matrix-assisted laser desorption ionization-time-of-flight (MALDI-TOF) mass spectrometry identified 25 spots comprising of 23 proteins. Two of 3 down-regulated proteins were identified as a heat shock protein 70 (HSP 70) and a GALE (UDP-galactose-4 epimerase) protein isoform I. The up-regulated proteins were Serpin H1, a protein involved in collagen metabolism and a redox sensor NmrA-like (NMRAL) family domain protein-1. Both GALE and NMRAL proteins are implicated in energy metabolism and redox regulation whereas the HSP 70 protects cells against stress, and implicated in chondrocyte hypertrophy, an important event in endochondral bone formation. The failure of chondrocyte protective mechanisms such as associated with protection against cellular stress and energy metabolism appear to be the likely cause for chondrocyte death induced by thiram.

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“…In der Milch wurden keine oder nur sehr geringe Mengen gefunden. Diazinon zeigte keine teratogenen Wirkungen bei oralen Gaben an Syrischen Goldhamstern und weißen Neuseeland-Kaninchen [25,26] sowie nach intraperitonealen Injektionen an Ratten [27]. Neurotoxische Spätsymptome konnten nach einmaliger und mehrmaliger Verabreichung an Hühnern nicht festgestellt werden [18,[28][29][30].…”

unclassified

Diazinon [MAK Value Documentation in German language, 1975]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 4. Lieferung, Ausgabe 1975 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität bei oraler oder parenteraler Aufnahme Orale Toxizität bei wiederholter Verabreichung Inhalationstoxizität Begründung des MAK‐Wertes

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Teratologic studies of carbaryl, diazinon, norea, disulfiram, and thiram in small laboratory animals

Cited by 131 publications

References 4 publications

Application of the chicken embryo in testing for embryotoxicity: thiurams.

Application of the chicken embryo in testing for embryotoxicity: thiurams.

Effect of thiram on avian growth plate chondrocytes in culture

Diazinon [MAK Value Documentation in German language, 1975]

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