Teratoma showing the features of retinal structure: A case of sacrococcygeal teratoma

Abstract

Abstract. Teratoma is a tumor that forms triploblastic tissues and the common sites of occurrence are sacrococcygeal lesions and the ovaries. The majority of cases are curable with surgical resection and the prognosis depends on the extent and histological scoring of the tumor. In the present study, we report a case of sacrococcygeal teratoma of a newborn showing features of a retina-like structure. A 29-year-old woman gave birth prematurely to an infant girl with sacrococcygeal teratoma. Surgical resection was performed 10 days after delivery. The tumor contained immature components as well as a retina-like structure. Several investigations, including immunohistochemical analysis, confirmed the similarities between the normal mouse retina and the retina-like structure of the tumor. The vascular arrangement and polarity surrounding the retina-like structure are unique and this is thought to be significant in the induction of structural differentiation. Our findings may provide insights into the matter of teratogenic activity in stem cell therapies for clinical applications.

Characterization of the Nonendocrine Cell Populations in Human Embryonic Stem Cell–Derived (hESC) Islet-Like Clusters Posttransplantation

“…26 The presence of retinal pigmented epithelium in hESCderived islet implants has not been reported previously, although retinal-like tissue in teratomas has been reported in a few case studies. 27,28 With the absence of teratomas in the intermediate differentiated groups but where retinal pigmented epithelium developed in one animal after 26 weeks, we need an alternative explanation for the finding. The retina is derived from the optic neuroepithelium which develops from the anterior neuroectoderm, 29 whereas hESC-derived islet protocols are optimized for endoderm-lineage pancreatic development and thus a different germ layer.…”

Ectopic ocular tissue in testicular teratoma: A case report and review of the literature

“…Sergi et al [12] and Takamatsu et al [13] reported a fetal sacrococcygeal teratomas with the development of a completely formed eye in the former, and retina-like structure with immature neural components of true rosettes and primitive neural tubes in the latter. They pointed the importance of blood supply and high oxygen concentration for the formation of rods and cones based on their hypothesis that these factors are important in the differentiation of the cells.…”

Immature teratoma of the tectum mesencephali with histopathological detection of rudimentary eye anlage in a 3‐year‐old boy: Report of a rare case

“…In 1999, Sergi et al published one case with a histopathologically confirmed optical component within a completely formed eye in fetal sacrococcygeal teratoma . Furthermore, in 2012 Takamatsu et al presented a similar case of sacrococcygeal teratoma with retina‐like structures in a newborn . The majority of data on immature teratoma today is gained from extracranial tumors.…”

“…15 Furthermore, in 2012 Takamatsu et al presented a similar case of sacrococcygeal teratoma with retina-like structures in a newborn. 16 The majority of data on immature teratoma today is gained from extracranial tumors. More reports and examinations of intracranial cases are needed to extend our understanding of this unique CNS tumor group.…”