Terbinafine hydrochloride treatment of Microsporum canis experimentally-induced ringworm in cats

Kotnik, Tina; Eržen, Nevenka Kožuh; Kuz̆ner, Jernej; Drobnič‐Košorok, M.

doi:10.1016/s0378-1135(01)00412-6

Cited by 29 publications

(52 citation statements)

References 10 publications

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“…In a study in cats, doses of 30–40 mg/kg once daily were required for treatment of M. canis dermatophytosis. Lower doses (10–20 mg/kg) were not different from the untreated control group (Kotnik et al ., 2001).…”

Section: Terbinafinementioning

confidence: 82%

Antifungal agents of use in animal health – practical applications

Rochette

Engelen

Bossche

2003

Vet Pharm & Therapeutics

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Section: Terbinafinementioning

confidence: 82%

Antifungal agents of use in animal health – practical applications

Rochette

Engelen

Bossche

2003

Vet Pharm & Therapeutics

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“…Terbinafine has been shown to persist in human stratum corneum, nails, hair, and sebum for several months past treatment 14 . Fungicidal concentrations of terbinafine have also been demonstrated in cat hair after only 9 days of oral treatment 9 . However, in this study the investigators did not evaluate the continual concentration of terbinafine in the hair after stopping therapy 9 .…”

Section: Introductionmentioning

confidence: 79%

“…Terbinafine (Lamisil® 250 mg tablets, Novartis, Auckland, New Zealand) was given once daily for 14 consecutive days at a dose range of 34–45.7 mg kg −1 . The dose range was aimed for 30–40 mg kg −1 , as a previous study 9 has showed greater efficacy and higher levels of terbinafine in hair at higher dose ranges. Cats weighing 4.1–6.0 kg received 187.5 mg (3/4 tablet), cats weighing between 6.1 and 8.0 kg received 250 mg (1 tablet), and cats weighing = 8.1 kg received 312.5 mg (1.25 tablets).…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy

Foust¹,

Marsella²,

Akucewich³

et al. 2007

Veterinary Dermatology

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This study determined the residual concentration of terbinafine in cat hair after 14 days of oral treatment. Ten clinically normal cats were administered terbinafine orally at a daily dose of 34-45.7 mg kg(-1) for a total of 14 days. Areas of 15 cm(2) were shaved on the lateral thorax at day 0 and weekly for 8 weeks after the last dose of terbinafine. The hair samples were analysed by high-pressure liquid chromatography to determine the persistence of terbinafine over time. The mean terbinafine concentration in hair was 2.30 ng mg(-1) after 14 days of therapy. The half life was 1.84 weeks after the last dose of terbinafine. With a 99% confidence interval, the concentration of terbinafine remained in the cat hair at or above 0.03 ng mg(-1) (minimal inhibitory concentration (MIC)(90) = 0.03 microg mL(-1)) for 5.3 weeks. Slight deviations in the complete blood cell count and serum chemistry values were not attributed to terbinafine. Four cats experienced vomiting during the terbinafine treatment; two of these cats also experienced intense facial pruritus followed by a macular to papular skin reaction 7-14 days after the discontinuation of terbinafine. In summary, terbinafine persists in hair at concentrations above the MIC for several weeks after stopping medication, even after short-term therapy (14 days). These results suggest that pulse therapy of terbinafine should be further researched and potentially considered as a treatment modality for feline dermatophytosis, an approach that would decrease treatment duration while maintaining effectiveness.

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“…However, C. laniger is an animal that naturally ingests small amounts of water and its hair is refractory to water penetration, we chose not to perform systemic therapy due to the risk of nephrotoxicity and to the non-use of baths with shampoo added of antifungal agents due to the risk of therapeutic inefficiency. The use of terbinafine was selected for therapeutic efficacy already evaluated in small animals (Kuźner et al, 2000;Kotnik et al, 2001). …”

Section: Discussionmentioning

confidence: 99%

Ringworm by Microsporum canis in Long-tailed chinchilla (Chinchilla lanigera)

Marietto-Gonçalves

2015

AVB

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-Long-tailed chinchillas are rodents popularly bred as pets for being a docile animal; however, in the natural environment, it is a critically endangered species. This study reports the occurrence of ringworm in Chinchilla lanigera. A female specimen presenting an alopecia-oval lesion on the left cheek was send for clinical care. On examination, the lesion was positive for the Wood test and on the hematological evaluation, and in the mycological assessment was performed and Microsporum canis was isolated after 10 days of incubation on Sabouraud Dextrose Agar. The animal was treated with topical solution of chlorhexidine and iodopovedine, hydrocortisone ointment and terbinafine cream. Ringworm is an uncommon infection in rodents and M. canis is a commensal fungus of the skin of dogs, being a parasite primarily zoophilic but can cause injury to humans. Ringworms are uncommon in rodents, being attributed in this report to stress associated to indirect contact with canine material contaminated with the fungus.Keywords: Dermatology; exotic animals medicine; mycosis; pets; rodents.RESUMO -Chinchilas são roedores popularmente criados como animais de estimação por ser um animal dócil, porém em ambiente natural é uma espécie criticamente ameaçada de extinção. O presente artigo relata a ocorrência de dermatofitose em Chinchilla lanigera. Uma fêmea foi encaminhada para atendimento clínico apresentando uma lesão alopécica-ovalada em face esquerda. No exame clínico a lesão era positiva para o teste de Wood e na avaliação micológica sendo isolado Microsporum canis após 10 dias de incubação em Agar Sabouraud-Dextrose. O animal foi tratado com solução tópica de clorexidine e iodopovidona, pomada de hidrocortisona e creme de terbinafina. Dermatofitose é uma infecção incomum em roedores e atribuiu-se as alterações deste relato a estresse associado ao contato indireto com

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Terbinafine hydrochloride treatment of Microsporum canis experimentally-induced ringworm in cats

Cited by 29 publications

References 10 publications

Antifungal agents of use in animal health – practical applications

Antifungal agents of use in animal health – practical applications

Evaluation of persistence of terbinafine in the hair of normal cats after 14 days of daily therapy

Ringworm by Microsporum canis in Long-tailed chinchilla (Chinchilla lanigera)

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