Terbutaline Inhalation for Alleviation of Severe Pain in Essential Dysmenorrhea

Kullander, Stig; Svanberg, L

doi:10.3109/00016348109154139

Cited by 3 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the failure of hydroxyphenyl-orciprenalin [29], and isoxsuprine [30], to show any benefit in previous studies, another one reported pain relief with a combination of isoxsuprine, acetaminophen and caffeine [31]. Moreover, two studies reported pain relief in severe primary dysmenorrhea with terbutaline administered via spray inhalations [32] or intravenous injection, along with inhibition of the myometrial activity and increased uterine blood flow [33]. A recent review on the use beta2-adrenoceptor agonists for dysmenorrhea found that adverse effects with all these medications were reported in up to a quarter of the total number of participants and they included nausea, vomiting, dizziness, tremors and palpitations.…”

Section: Discussionmentioning

confidence: 98%

A Preliminary Pilot Randomized Crossover Study of Uzara (Xysmalobium undulatum) versus Ibuprofen in the Treatment of Primary Dysmenorrhea

et al. 2014

View full text Add to dashboard Cite

ObjectivePreliminary evaluation of efficacy and safety of uzara use in treatment of moderate and severe primary dysmenorrhea in comparison to ibuprofen.Materials and MethodsThis randomized, comparative two way cross-over study comprised 60 single female students at Faculty of Medicine, Ain Shams University, Egypt, aged 19–28 years with moderate (n = 46) or severe (n = 14) primary dysmenorrhea. Participants were randomized to take either uzara (80 mg/8 hours for two doses, then 40 mg/8 hours) then ibuprofen (400 mg/6 hours) in two subsequent cycles or vice versa. The pain intensity, using VAS, was recorded immediately before taking the medication (0 hour) and after 4, 12, 24, 48–60, 96–120 hours. Main outcome measures included effectiveness of pain relief defined as drop of VAS to 3 or less, patient's global evaluation of the drug, absence from school, the use of a rescue medication, and, in those who continued the treatment, the pain intensity difference (PID) at different points after start of medication and its sum (SPID).ResultsUzara was comparably effective to ibuprofen (78.3% vs. 86.7% of cycles; respectively), with comparable rates of effectiveness on global evaluation (being around 50% for either drug), and rates of school absences (11.7% vs. 13.3%; respectively). The need for rescue medication was different (18.3% and 10%; respectively), albeit with no statistical significance. The means of PID at different time points and SPID were comparable, with significantly lower average mean of VAS scores compared to that felt with no medication (1.6 vs. 6.8, p<0.001). Side effects were less with uzara than ibuprofen (0% vs. 8.3%, p<0.05).ConclusionsUzara might be as effective as ibuprofen in management of primary dysmenorrhea but with less side effects. These findings need to be confirmed by a properly designed trial with a larger sample size.Trial RegistrationCurrent Controlled Trials ISRCTN25618258

show abstract

Section: Discussionmentioning

confidence: 98%

A Preliminary Pilot Randomized Crossover Study of Uzara (Xysmalobium undulatum) versus Ibuprofen in the Treatment of Primary Dysmenorrhea

et al. 2014

View full text Add to dashboard Cite

show abstract

Beta2-adrenoceptor agonists for dysmenorrhoea

Fedorowicz

Nasser

Jagannath³

et al. 2012

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

show abstract

On Resorption and the Effects of Vaginally Administered Terbutaline in Women With Premature Labor

Kullander¹,

Svanberg²

1985

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

In a randomized, single-blind study, of a pilot nature, the administration of terbutaline sulphate was found to cause significant inhibition of contractions in premature labor. This effect became evident within 30 min when the dosage was 0.1 mg in 1 ml cellulose gel, applied vaginally, and within 2 h when released from a 5-g medicated vaginal polymer ring containing 10% terbutaline sulphate. No generalized effects of the terbutaline were noted (such as increased blood pressure or tachycardia) and the level of terbutaline in peripheral venous blood remained low. Vaginally administered terbutaline can obviously be quickly resorbed, giving a localized effect. Thus applied, terbutaline would appear to offer a number of advantages as regards treatment procedure.

show abstract

Terbutaline Inhalation for Alleviation of Severe Pain in Essential Dysmenorrhea

Abstract: In a double-blind cross-over study the effect of terbutaline spray (Bricanyl aerosol) inhalations was tested in 14 women with severe dysmenorrhea. A significant relief was noted in association with an increased menstrual blood loss. The side effects were few.

Cited by 3 publications

References 14 publications

A Preliminary Pilot Randomized Crossover Study of Uzara (Xysmalobium undulatum) versus Ibuprofen in the Treatment of Primary Dysmenorrhea

A Preliminary Pilot Randomized Crossover Study of Uzara (Xysmalobium undulatum) versus Ibuprofen in the Treatment of Primary Dysmenorrhea

Beta2-adrenoceptor agonists for dysmenorrhoea

On Resorption and the Effects of Vaginally Administered Terbutaline in Women With Premature Labor

Contact Info

Product

Resources

About