Terminal Differentiation of Mesodiencephalic Dopaminergic Neurons:

Smidt, Marten P.; Peter, J.; Burbach, Harold J.

doi:10.1007/978-1-4419-0322-8_4

Cited by 21 publications

(25 citation statements)

References 75 publications

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“…Nurr1 and FGFR1 are central nuclear integrators of diverse developmental signals (4,11,13). Both proteins have been implicated in postmitotic development, including the maturation and maintenance of mDA neurons (3,51,52).…”

Section: Discussionmentioning

confidence: 99%

“…The differentiating mDA neurons start to build rostrally directed projections to their forebrain targets as soon as they begin to express tyrosine hydroxylase (TH) (2), the rate-limiting enzyme in dopamine synthesis. Two nuclear factors, Nurr1 and FGFR1, control terminal differentiation, maturation, and maintenance of mDA neurons (3,4). Nurr1 (NR4A2) belongs to the subfamily of orphan nuclear receptors, which lack ligand binding capacity, typically present in other nuclear receptors (5).…”

Section: Experiments In Mice Deficient For Nurr1 or Expressing The Domentioning

confidence: 99%

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Cooperation of Nuclear Fibroblast Growth Factor Receptor 1 and Nurr1 Offers New Interactive Mechanism in Postmitotic Development of Mesencephalic Dopaminergic Neurons

Baron

Förthmann

Lee

et al. 2012

Journal of Biological Chemistry

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Background: Nurr1 and FGFR1 are integrative nuclear factors participating in postmitotic dopaminergic neuron development. Results: Both nuclear receptors show a functional interaction in co-immunoprecipitation, FRAP, ChIP, and luciferase gene reporter assay. Conclusion: Cooperation of nuclear FGFR1 and Nurr1 offers a new mechanism in transcriptional regulation and integration. Significance: This mechanism may channel diverse stimuli in developing and mature dopaminergic neurons, providing a potential therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Section: Experiments In Mice Deficient For Nurr1 or Expressing The Domentioning

confidence: 99%

Cooperation of Nuclear Fibroblast Growth Factor Receptor 1 and Nurr1 Offers New Interactive Mechanism in Postmitotic Development of Mesencephalic Dopaminergic Neurons

Baron

Förthmann

Lee

et al. 2012

Journal of Biological Chemistry

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“…Genes implicated in this sex-specific epigenetic dysregulation include WNT1 , a locus involved in the Wnt signaling pathway known to be important in neurodevelopment [47] , which shows significantly higher methylation in female (but not male) MP patients vs. controls. The same study also identified increased DNAm levels in NR4A2, whose expression controls differentiation of dopaminergic neurons [48] , in female MP patients, as well as additional neurodevelopmental genes (i.e. LMX1B, LHX5 , FOSB ) that showed contrasting patterns of DNAm in female—but not male—MP patients vs. controls.…”

Section: Dna Methylation Variation May Contribute To Sex Differenmentioning

confidence: 92%

Sex Differences in Dna Methylation May Contribute to Risk of PTSD and Depression: A Review of Existing Evidence

Uddin

Sipahi

et al. 2013

Depress Anxiety

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There are well-established sex differences in the prevalence of certain mental disorders. Work in animal models has provided us with an emerging understanding of the role that epigenetic factors play in establishing sex differences in the brain during development. Similarly, work in animal models, and a more limited but growing literature based on human studies, has demonstrated that DNA methylation (DNAm) changes occur in response to environmental stress, with some of these occurring in a sex-specific manner. In this review, we explore whether DNAm plays a role in contributing to the observed sex differences in prevalence of mental disorders in which stress contributes significantly to their etiologies, specifically post-traumatic stress disorder (PTSD) and depression. We propose that investigating sex differences in DNAm among genes known to influence brain development may help to shed light on the sexually dimorphic risk for, or resilience to, developing PTSD and depression.

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“…However, SLIT2 expression is detected in a sparse population of striatal neurons, which are presumed to be cholinergic striatal inhibitory interneurons. Additionally, SLIT2 expression begins around postnatal day 5, suggesting a potential pruning mechanism for mdDA projections expressing ROBO (Dimitrova et al ; Ozdinler & Erzurumlu ; Pasterkamp et al ; Smidt & Burbach ). Interestingly, neither the mesostriatal pathway nor the mesolimbic pathways appear to display a preference for dorsal or ventral striatum (Hu et al ).…”

Section: Neurodevelopment Of Mesodiencephalic Dopamine Neuronsmentioning

confidence: 99%

Development and function of the midbrain dopamine system: what we know and what we need to

Bissonette

Roesch

2015

Genes Brain and Behavior

109

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The past two decades have seen an explosion in our understanding of the origin and development of the midbrain dopamine system. Much of this work has been focused on the aspects of dopamine neuron development related to the onset of movement disorders such as Parkinson’s disease, with the intent of hopefully delaying, preventing or fixing symptoms. While midbrain dopamine degeneration is a major focus for treatment and research, many other human disorders are impacted by abnormal dopamine, including drug addiction, autism and schizophrenia. Understanding dopamine neuron ontogeny and how dopamine connections and circuitry develops may provide us with key insights into potentially important avenues of research for other dopamine-related disorders. This review will provide a brief overview of the major molecular and genetic players throughout the development of midbrain dopamine neurons and what we know about the behavioral- and disease-related implications associated with perturbations to midbrain dopamine neuron development. We intend to combine the knowledge of two broad fields of neuroscience, both developmental and behavioral, with the intent on fostering greater discussion between branches of neuroscience in the service of addressing complex cognitive questions from a developmental perspective and identifying important gaps in our knowledge for future study.

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Terminal Differentiation of Mesodiencephalic Dopaminergic Neurons:

Cited by 21 publications

References 75 publications

Cooperation of Nuclear Fibroblast Growth Factor Receptor 1 and Nurr1 Offers New Interactive Mechanism in Postmitotic Development of Mesencephalic Dopaminergic Neurons

Cooperation of Nuclear Fibroblast Growth Factor Receptor 1 and Nurr1 Offers New Interactive Mechanism in Postmitotic Development of Mesencephalic Dopaminergic Neurons

Sex Differences in Dna Methylation May Contribute to Risk of PTSD and Depression: A Review of Existing Evidence

Development and function of the midbrain dopamine system: what we know and what we need to

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