Termination and secondary projections of carotid sinus nerve in the cat brain stem

Miura, Mitsuhiko; Dj, Reis

doi:10.1152/ajplegacy.1969.217.1.142

Cited by 264 publications

(79 citation statements)

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“…The nucleus tractus solitarius (NTS) is the primary site of termination of afferent nerve fibers arising from arterial and cardiopulmonary mechanoreceptors (Crill and Reis, 1968;Murra and Reis, 1969;Seller and Illert, 1969;Jordan and Spyer, 1977;Ciriello and Calaresu, 198 1). Neurons in the NTS integrate these and other circulatory related afferent signals and are important in the production of appropriate patterns of cardiovascular, pulmonary, and other homeostatic responses (Spyer,198 1).…”

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confidence: 99%

Cardiovascular function is altered by picomole injections of glutamate into rat medulla

et al. 1988

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Local neural circuitry in the nucleus tractus solitarius (NTS) involved in cardiovascular control was studied by injecting nanoliter volumes of excitatory amino acids into the structure. Experiments were performed on urethane-anesthetized, artificially ventilated rats. Multibarrel micropipettes were used for pressure ejection of drugs or a dye for marking ejection sites. Ejected volumes, ranging from 200 pl to 25 nl, were directly monitored for every injection. Injections of as little as 200 fmol of L-glutamate in 200 pl into the medial and lateral NTS region rostral to the obex elicited marked, site-specific decreases in arterial pressure and heart rate. The majority of these responses were eliminated by blockade of parasympathetic and sympathetic neural outflow. At sites caudal to obex, in the commissural region of the NTS, L-glutamate injections produced marked elevations in heart rate and arterial pressure which were sympathetically mediated. Responses to L- glutamate were attenuated by concurrent injection of glutamic acid diethyl ester and DL-2-amino-4-phosphonobutyrate, or lidocaine. These results indicate a heterogeneity in the spatial organization of brain- stem circuitry underlying cardiovascular control that has not been previously described.

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confidence: 99%

Cardiovascular function is altered by picomole injections of glutamate into rat medulla

et al. 1988

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“…The intermediate portion of the SOL is known to receive the terminals of of ferents of the carotid sinus nerve (MIURA andREIS, 1969, PANNETON andLoEWY, 1980), and of the aortic nerve (KALIA and WELLES, 1980;KUMADA and NAKAJIMA, 1972). The sensory afferents, which come from the heart or lung and ascend along the vagus nerve, also terminate there (KALIA and MESULAM, 1980).…”

Section: Discussionmentioning

confidence: 99%

An increase in cerebral blood flow elicited by electrical stimulation of the solitary nucleus in rats with cervical cordotomy and vagotomy.

Nakai

1985

Jpn.J.Physiol

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The effect of monopolar electrical stimulation of the intermediate portion of the solitary nucleus (SOL) on brain circulation was investigated in 48 anesthetized (N2O), artificially ventilated Wistar rats. The cervical spinal cord and bilateral vago-sympathetic trunks were severed to eliminate any change in arterial blood pressure mediated by the autonomic nervous systems on stimulating the SOL. Blood pressure was kept within the physiological range by intravenous phenylephrine infusion. Current intensity of the stimulus was set at 60+4uA (mean +S.E.; n=9), which was equivalent to 2.5 times threshold for vasopressin-induced pressor response. A sufficient dose of vasopressin-antagonist given to each rat shortly before determination of cerebral blood flow, prevented vasopressin-induced hypertension from stimulating the medulla. Stimulation elicited an increase in regional blood flow (14C-iodoantipyrine technique) by 72%, and 39 % on average in the frontal and occipital cortices, respectively, and 25% in the caudate-putamen (p<0.05; n=12 in control, and 9 in the stimulation studies). It was found that observed results included little detectable contribution from current spread of the stimulus toward the adjacent structures (dorsal medullary reticular formation and cuneate fasciculus) surrounding the SOL and from retrograde activation of the cerebellar fastigial nucleus. Overall, the present study suggests that a certain vasomotor mechanism, which is activated upon excitation of the intermediate portion of the SOL, regulates the blood vessels of the brain as a vasodilator.

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“…The intermediate and commissural portions of the NTS are mostly known as the "cardiovascular NTS". The intermediate NTS receives mainly carotid and aortic baroreceptor afferents, while the commissural NTS is the site of termination of arterial chemoreceptors and also aortic baroreceptor fibers (Cottle 1964, Crill and Reis 1980, Miura and Reis 1969, 1972, Spyer 1981, Finley and Katz 1992, Ciriello et al 1994, Colombari et al 1996. Information arriving from these afferents into the NTS, which in turn sends efferent projections to different areas involved in cardiovascular regulation.…”

Section: The Nucleus Of the Solitary Tract (Nts): Old And New Pathwaymentioning

confidence: 99%

Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP

Cravo

Campos

Colombari

et al. 2009

An. Acad. Bras. Ciênc.

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Several forms of experimental evidence gathered in the last 37 years have unequivocally established that the medulla oblongata harbors the main neural circuits responsible for generating the vasomotor tone and regulating arterial blood pressure. Our current understanding of this circuitry derives mainly from the studies of Pedro Guertzenstein, a former student who became Professor of Physiology at UNIFESP later, and his colleagues. In this review, we have summarized the main findings as well as our collaboration to a further understanding of the ventrolateral medulla and the control of arterial blood pressure under normal and pathological conditions.

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Termination and secondary projections of carotid sinus nerve in the cat brain stem

Cited by 264 publications

References 0 publications

Cardiovascular function is altered by picomole injections of glutamate into rat medulla

Cardiovascular function is altered by picomole injections of glutamate into rat medulla

An increase in cerebral blood flow elicited by electrical stimulation of the solitary nucleus in rats with cervical cordotomy and vagotomy.

Role of the medulla oblongata in normal and high arterial blood pressure regulation: the contribution of Escola Paulista de Medicina - UNIFESP

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