Terminology

Anderson, Paul A.; Andersson, Gunnar; Arnold, Paul M.; Brodke, Darrel S.; Brodt, Erika D.; Chou, Dean; Dekutoski, Mark B.; Dettori, Joseph R; DeVine, John G.; Ely, Claire G.; Fehlings, Michael G.; Fischer, Dena J.; Fourney, Daryl R.; Hansen, Mitchell A.; Harrod, Christopher C.; Hashimoto, Robin; Hermsmeyer, Jeffrey T.; Hilibrand, Alan S.; Kasliwal, Manish K.; Kelly, Michael P.; Kim, Hee Jin; Kraemer, Paul; Lawrence, Brandon D.; Lee, Michael J.; Lenke, Lawrence G.; Norvell, Daniel C; Raich, Annie; Riew, K. Daniel; Shaffrey, Christopher I.; Skelly, Andrea C.; Smith, Justin S.; Standaert, Christopher J.; Alstyne, Ellen M. Van; Wang, Jeffrey C.

doi:10.1097/brs.0b013e31826d62ed

Cited by 15 publications

(8 citation statements)

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“…6 , 7 ASD includes "radiographical ASD" and "clinical ASD": "radiographical ASD" refers to radiological changes that occur at the adjacent segment and "clinical ASD" refers to clinical symptoms and signs that occur at the adjacent segment. 8 There are some reports on the incidence of ASD after lumbar fusion surgery, and they state that radiographical ASD was observed in 36% to 84% of patients followed-up for 5 years after lumbar fusion surgery. 7 , 9-17 However, only a small number of these patients had clinical symptoms and required reoperation for ASD.…”

mentioning

confidence: 97%

Adjacent Segment Disease After Posterior Lumbar Interbody Fusion

Nakashima

Kawakami

Tsuji

et al. 2015

Spine

137

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mentioning

confidence: 97%

Adjacent Segment Disease After Posterior Lumbar Interbody Fusion

Nakashima

Kawakami

Tsuji

et al. 2015

Spine

137

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“…Other complications associated with the anterior approach include intermittent early dysphagia which in most cases resolves [17]. In addition, adjacent segment disease (ASD) may occur, as spinal fusion has been blamed for increasing the incidence of degeneration in adjacent levels [18]. 25.6% will develop ASD within 10 years after ACDF and 7.5% will need further surgery.…”

Section: Background and Rationale {6a}mentioning

confidence: 99%

Operative treatment of cervical radiculopathy: anterior cervical decompression and fusion compared with posterior foraminotomy: study protocol for a randomized controlled trial

Holy

MacDowall

Sigmundsson

et al. 2021

Trials

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Background Cervical radiculopathy is the most common disease in the cervical spine, affecting patients around 50–55 year of age. An operative treatment is common clinical praxis when non-operative treatment fails. The controversy is in the choice of operative treatment, conducting either anterior cervical decompression and fusion or posterior foraminotomy. The study objective is to evaluate short- and long-term outcome of anterior cervical decompression and fusion (ACDF) and posterior foraminotomy (PF) Methods A multicenter prospective randomized controlled trial with 1:1 randomization, ACDF vs. PF including 110 patients. The primary aim is to evaluate if PF is non-inferior to ACDF using a non-inferiority design with ACDF as “active control.” The neck disability index (NDI) is the primary outcome measure, and duration of follow-up is 2 years. Discussion Due to absence of high level of evidence, the authors believe that a RCT will improve the evidence for using the different surgical treatments for cervical radiculopathy and strengthen current surgical treatment recommendation. Trial registration ClinicalTrials.gov NCT04177849. Registered on November 26, 2019

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“…In recent years, a growing body of evidence suggests that long-term results may be compromised by the development of ASP. ASP in recent years has been defined by a consensus panel to help consolidate the literature regarding clinical (CASP) and radiographic (RASP) breakdown [3]. However, it is well established that progressive spinal degeneration occurs with time as a part of the natural aging process even in the absence of ACDF [26].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a consensus panel of spine surgeons proposed the term "Adjacent segment pathology (ASP)" to describe changes that occur adjacent to a previously fused level [3]. The subcategories of radiographic ASP (RASP) and clinical ASP (CASP) were also defined recently to consolidate the multitude of terms that historically have been used to describe this phenomenon.…”

Section: Terminologymentioning

confidence: 99%

Iatrogenic Contributions to Cervical Adjacent Segment Pathology

Ueda

Huang

Lebl

2015

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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Background: Anterior cervical discectomy and fusion (ACDF) is widely accepted as a predictably excellent procedure. On the other hand, adjacent level pathology following ACDF is a well-known phenomenon which undercuts surgical outcome. However, the extent to which ACDF accelerates this phenomenon in the naturally degenerating cervical spine is still to be understood. Questions/Purposes: To summarize the current evidence concerning adjacent segment pathology in the light of biomechanics, natural history, postoperative course, and comparison between ACDF and total disc replacement (TDR). Methods: This is a study of published articles. Articles were searched by the topic of adjacent disc pathology in cervical spine through Google Scholar and Pubmed. After review, 37 published articles were deemed suitable for the subject of this study. Results: Biomechanical and clinical data strongly suggest that ASP is a presentation of the iatrogenically accelerated natural aging process of cervical spine. However, power study analysis with assumption showed that current RCTs are unlikely to prove this suggestion. Conclusion: Available data suggests that iatrogenic factors play a significant role in adjacent segment pathology following ACDF.

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Terminology

Cited by 15 publications

References 0 publications

Adjacent Segment Disease After Posterior Lumbar Interbody Fusion

Adjacent Segment Disease After Posterior Lumbar Interbody Fusion

Operative treatment of cervical radiculopathy: anterior cervical decompression and fusion compared with posterior foraminotomy: study protocol for a randomized controlled trial

Iatrogenic Contributions to Cervical Adjacent Segment Pathology

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