Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-Ay mice

Kobayashi, Misato; Kawashima, Haruna; Takemori, Kumiko; Ito, Hiroyuki; Murai, Atsushi; Masuda, Shun; Yamada, Kaoru; Uemura, Daisuke; Horio, Fumihiko

doi:10.1016/j.bbrc.2012.09.045

Cited by 19 publications

(11 citation statements)

References 21 publications

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“…Ternatin, a cyclic peptide isolated from corioulus versicolor, and its derivative found to suppress hyperglycemia and hepatic fatty acid synthesis in diabetic Kuo Kondo yellow obese (KK-A(y)) mice. The main finding of this study proves that C. versicolor has lowered glucose, and triglycerides significantly ( p < 0.05) and Sterol regulatory element-binding protein-1c (SREBP-1c) mRNA level in hepatoma 1-6 (Hepa1-6) hepatocyte cells was reduced, but not significantly [ 30 ]. The SREBP-1c is an insulin-dependent molecule that regulates de novo lipogenesis.The positive regulation on the SREBP-1c can directly regulates hyperglycemia and fatty acid synthesis via insulin signaling.…”

Section: Medicinal Properties Of Mushroommentioning

confidence: 88%

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota

Jayachandran

Xiao

2017

IJMS

203

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Mushrooms have long been used for medicinal and food purposes for over a thousand years, but a complete elucidation of the health-promoting properties of mushrooms through regulating gut microbiota has not yet been fully exploited. Mushrooms comprise a vast, and yet largely untapped, source of powerful new pharmaceutical substances. Mushrooms have been used in health care for treating simple and common diseases, like skin diseases and pandemic diseases like AIDS. This review is aimed at accumulating the health-promoting benefits of edible mushrooms through gut microbiota. Mushrooms are proven to possess anti-allergic, anti-cholesterol, anti-tumor, and anti-cancer properties. Mushrooms are rich in carbohydrates, like chitin, hemicellulose, β and α-glucans, mannans, xylans, and galactans, which make them the right choice for prebiotics. Mushrooms act as a prebiotics to stimulate the growth of gut microbiota, conferring health benefits to the host. In the present review, we have summarized the beneficial activities of various mushrooms on gut microbiota via the inhibition of exogenous pathogens and, thus, improving the host health.

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Section: Medicinal Properties Of Mushroommentioning

confidence: 88%

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota

Jayachandran

Xiao

2017

IJMS

203

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“…It has also been suggested that polysaccharides are the best known and most potent mushroom-derived substances with antidiabetes and antitumor activities (48,49). However, a recent study concerning ternatin, a highly methylated cyclic heptapeptide isolated from the mushroom Coriolus versicolor, was found to inhibit hyperglycemia (50) suggesting the anti-diabetogenic activity by mushroom peptides. In the present study, we know through phenol-sulfuric acid and bicinchoninic acid methods that the major components in CLCE are exopolysaccharides (EPS) and proteins, and the amount of EPS and proteins is ~50:50% (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Crude extract of Ceriporia lacerata has a protective effect on dexamethasone-induced cytotoxicity in INS-1 cells via the modulation of PI3K/PKB activity

Kim

Park

Kim³

et al. 2013

International Journal of Molecular Medicine

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Abstract. Excessive and/or long-term glucocorticoid therapy reduces β-cell mass and induces hyperglycemia, which contribute to the development of steroid-induced diabetes. Ceriporia (C.) lacerata is one of the white-rot fungi and has been used in bioremediations, such as lignocellulose degradation, in nature. The pharmacologic effect of C. lacerata on steroid-induced β-cell toxicity is not known. In this study, we evaluated the effect of a crude extract from a submerged cultivation of C. lacerata on the survival and apoptosis of INS-1 rat insulin-secreting cells exposed to dexamethasone (Dex), a synthetic diabetogenic glucocorticoid. Treatment with the C. lacerata crude extract (CLCE) largely blocked the Dex-induced reduction in survival and apoptosis of INS-1 cells. Moreover, CLCE treatment inhibited Dex-induced protein kinase B (PKB) dephosphorylation without affecting Dex-induced extracellular signal-regulated protein kinase-1/2 dephosphorylation and MKP-1 upregulation. Importantly, the protective effect of CLCE on Dex-induced cytotoxicity in INS-1 cells was attenuated by LY294002, an inhibitor of PI3K/PKB. CLCE treatment, however, did not protect the INS-1 cells from the cytotoxic effects triggered by other insults, such as interleukin-1β (an inflammatory cytokine), streptozotocin (a diabetogenic drug), thapsigargin (a calcium mobilizing agent), and tunicamycin (an ER stress inducer).Collectively, these findings demonstrate for the first time the ability of CLCE to specifically protect INS-1 cells from Dex-induced cytotoxicity through the modulation of the PI3K/ PKB pathway. It is suggested that CLCE may be applied for the prevention and/or treatment of steroid diabetes in which reduction of β-cell survival and induction of β-cell apoptosis play pathogenic roles.

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“…The content of biologically active compounds in mushrooms makes them beneficial to humans. They might have the potential to prevent malignant diseases, hypercholesterolemia, diabetes, hypertension, inflammation, liver dysfunction, viral and bacterial infections or cardiovascular diseases [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Health risk assessment of exposure to toxic elements resulting from consumption of dried wild-grown mushrooms available for sale

et al. 2021

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Mushrooms exhibit a high ability to accumulate potentially toxic elements. The legal regulations in force in the European Union countries do not define the maximum content of elements in dried wild-grown mushrooms. This study presents the content of mercury (Hg), lead (Pb), cadmium (Cd) and arsenic (As) determined in dried wild-grown mushrooms (Boletus edulis and Xerocomus badius) available for sale. Moreover, the health risk associated with their consumption is assessed. The inductively coupled plasma mass spectrometry (Cd, Pb, As) and atomic absorption spectrometry (Hg) were used. The mean Hg, Cd, Pb and As concentration in Boletus edulis was 3.039±1.092, 1.983±1.145, 1.156±1.049 and 0.897±0.469 mg/kg and in Xerocomus badius 0.102±0.020, 1.154±0.596, 0.928±1.810 and 0.278±0.108 mg/kg, respectively. The maximum value of the hazard index (HI) showed that the consumption of a standard portion of dried Boletus edulis may have negative consequences for health and corresponded to 76.2%, 34.1%, 33% and 4.3% of the maximum daily doses of Hg, Cd, Pb and As, respectively. The results indicate that the content of toxic elements in dried wild-grown mushrooms should be monitored. The issue constitutes a legal niche where unfavourable EU regulations may pose a threat to food safety and consumer health.

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Ternatin, a cyclic peptide isolated from mushroom, and its derivative suppress hyperglycemia and hepatic fatty acid synthesis in spontaneously diabetic KK-Ay mice

Cited by 19 publications

References 21 publications

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota

A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota

Crude extract of Ceriporia lacerata has a protective effect on dexamethasone-induced cytotoxicity in INS-1 cells via the modulation of PI3K/PKB activity

Health risk assessment of exposure to toxic elements resulting from consumption of dried wild-grown mushrooms available for sale

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