Terpene Glycosides and Cytotoxic Constituents from the Seeds ofAmomum xanthioides

Abstract

Column chromatographic isolation of the MeOH extract of the seeds of Amomum xanthioides afforded a new diterpene glycoside, amoxanthoside A (1), two new monoterpene glycosides, (1 S,4 S,5 S)-5- EXO-hydroxycamphor 5-O-beta-D-glucopyranoside (2) and (1 R,4 R,5 S)-5-ENDO-hydroxycamphor 5-O-beta-D-glucopyranoside (3), together with four known compounds, hedychiol A (4), pygmol (5), (1 S,4 R,6 R)-(+)-6- ENDO-hydroxycamphor (6), and dihydroyashabushiketol (7). The structures of the new compounds were determined through spectral analysis, including extensive 2D NMR data. The isolated compounds were tested for their cytotoxicity against four human cancer cell lines IN VITRO using a sulforhodamine B bioassay.

Phenolic Glycosides from Capsella bursa-pastoris (L.) Medik and Their Anti-Inflammatory Activity

“…HMBC correlations and NOESY cross-peaks ( Figure 2 ) reconfirmed the suggested structure of 1 . The enzymatic hydrolysis of 1 afforded d -glucose, which was identified by the sign of the specific rotation +48.2 ( c = 0.03, H 2 O) and by co-TLC (CHCl 3 :MeOH:H 2 O = 2:1:0.1; R f = 0.21) [ 20 ] and the aglycone 1a , which was identified by 1 H-NMR and MS data [ 17 ]. Thus, the structure of 1 was determined as (7 R , 8 S , 8′ S , 7″ S , 8″ R )-abiesol A 4″- O -β- d -glucopyranoside, and it was named capselloside.…”

New Triterpenoids from the Tubers ofCorydalis ternata:Structural Elucidation and Bioactivity Evaluation

“…The IR spectrum indicated that 1 possesses hydroxy (3383 cm −1 ), carbonyl (1666 cm −1 ), and C=C double bond (1642 cm −1 ) functional groups. The 1 H and 13 C NMR spectra of 1 (l " Tables 1 and 2) were similar to those of serratagenic acid [4] [5,6]. Comparison of the 13 C NMR data of 1 with that of serratagenic acid showed the downfield shift of C-3 (+ 11.5) and upfield shift of C-2 (− 2.5) in 1, indicating glycosylation at C-3.…”

“…This evidence, together with the observation of the HMBC correlation between O-CH 3 (δ H 3.77) and C-6′ (δ C 169.9), suggested that compound 2 contains a 6′-O-methyl-β-glucuronopyranoside [8]. Acidic hydrolysis and spectral analysis of 2 confirmed the presence of the 6′-O-methyl-β-D-glucuronopyranoside from the 1 H NMR coupling constant (J = 8.0 Hz) and its optical rotation value [6][7][8]. The relative configuration of 2 was confirmed to be identical to that of 1 in the NOESY spectrum.…”

9′-Epi-3β,3′β-dimethylxestospongin C, a New Macrocyclic Diamine Alkaloid from the Hainan SpongeNeopetrosia exigua

“…MTT [17] and SRB [18] bioassays were used to determine the cytotoxicity of each compound against HL60 and A549 tumor cell lines, respectively. Doxorubicin (purity ≥ 99.5 %; Dalian Melone Pharmaceutical Co., Ltd.) was used as a positive control.…”