Terpenoids from Achillea distans Waldst. &amp; Kit. ex Willed

Todorova, Milka; Трендафилова, Антоанета; Mikhova, B.M.; Vitkova, Antonina; Duddeck, H.

doi:10.1016/j.bse.2007.03.019

Cited by 15 publications

(14 citation statements)

References 17 publications

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“…In the aqueous extract of this species several further compounds, estafiatin, leucomisin, artecanin were found [36]. 1,4--endoperoxyguaianolides may be the most significant components of A. distans [37] while 11,13-dehydrodeacetylmatricarin was found as major constituent of A. pannonica [38] and of A. setacea [39]. Research of the last period reveals more and new guaianolid compounds, like 8 -hydroxy-tanaparthin--peroxide from A. setacea [39], or anobin in A. nobilis [40].…”

Section: Guaianolidesmentioning

confidence: 97%

Biological Activities of Yarrow Species (Achillea spp.)

Németh

Bernáth

2008

CPD

136

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The genus Achillea consists of about 140 perennial herbs native to the Northern hemisphere. Traditional indications of their use include digestive problems, liver and gall-bladder conditions, menstrual irregularities, cramps, fever, wound healing. The Commission E approves its internal use for loss of appetite and dyspeptic ailments (gastric catarrh, spastic discomfort), externally it is used in form of sitz bath or as a compress against skin inflammation, slow healing wounds, bacterial or fungal infections. In the last decades, pharmacological studies became intensive, although human clinical investigations are still rare. Recent findings have confirmed several traditional uses. The largest number of data accumulated for antioxidant and anti-inflammatory effects. There are positive results on the analgesic, anti-ulcer, choleretic, hepatoprotective and wound healing activities. First results on other interesting therapeutical areas - antihypertensive, antidiabetic, antitumor, antispermatogenic activities -need confirmation. Yarrow can be used also as an insect repellent. Contact dermatitis as adverse effect may be connected to sesquiterpenes. The diversity and complexity of the effective compounds of yarrow species explains the broad spectrum of their activity. According to the literature the pharmacological effects are mainly due to the essential oil, proazulenes and other sesquiterpene lactones, dicaffeoylquinic acids and flavonoids. Synergistic actions of these and other compounds are also supposed. Achillea species have different chemical and therapeutical values. Despite of numerous data, correct evaluation of the results is difficult because of missing generally accepted taxonomical nomenclature. The used chemical-analytical methods and bio-assays are utmost diverse, making the comparison complicated. Further research on the activity is needed using exactly defined plant material, standardized methods and chemical analysis.

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Section: Guaianolidesmentioning

confidence: 97%

Biological Activities of Yarrow Species (Achillea spp.)

Németh

Bernáth

2008

CPD

136

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“…This lactone had been isolated from Artemisia montana, 359 and has now been found in Achillea distans. 207 The diastereomers 437 and 438 have been identified in an extract from Achillea collina. 75 The authors of this work also suggest that the structure assigned to a 2a,4a-dihydroxy lactone, isolated from several European Achillea species, 360 must be corrected to 437.…”

Section: Eremophilane and Bakkanementioning

confidence: 99%

Natural sesquiterpenoids

Fraga

2008

Nat. Prod. Rep.

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“…94 Achicollinolide 93 was found in the flower heads of Achillea collina, 95 whilst the distansolides A and B 94-95 were obtained from the flower heads of Achillea distans. 96 A phytochemical investigation of Ainsliaea macrocephala led to the isolation of ainsliadimer A 96. Its structure was elucidated by spectroscopic and single-crystal X-ray diffraction analyses.…”

Section: Guaiane and Pseudoguaiane Sesquiterpenoid Dimersmentioning

confidence: 99%