Terpenoids: natural products for cancer therapy

Abstract

The anti-cancer activity of terpenoids appears promising and will potentially open more opportunities for cancer therapy. However, current studies are restricted to descriptive findings and lack mechanistic insights and systematic structure-activity relationship (SAR) studies. Future efforts into the systematic identification of the targets of terpenoids are believed to increase chances of gaining breakthrough insights in the field.

Identification of novel anticancer terpenoids from <i>Prosopis juliflora</i> (Sw) DC (Leguminosae) pods

“…It will bring a revolution in cancer treatment with less side effects and low cost. Many scientists proposed that terpenoids are natural products for cancer therapy [20].…”

Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells

“…Natural products are a favorable resource for anticancer drug discovery [32][33][34][35][36] . As the principal active component in Platycodonis Radix, PD has been confirmed to have potential anticancer effects by inhibiting proliferation, inducing apoptosis, inducing cell cycle arrest, and blocking metastasis [9,10,[13][14][15]37] .…”

Platycodin D Induces Apoptosis, and Inhibits Adhesion, Migration and Invasion in HepG2 Hepatocellular Carcinoma Cells

“…A large number of (Chen et al, 2012;Huang et al, 2012;Lu et al, 2012a;Lu et al, 2012b;Lu et al, 2013). Therefore, it is vital to screen efficient natural compounds for hepatocellular carcinoma treatment.…”