Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia

Lia, Zhen-Jie; Wan, Chunping; Cai, Le; Li, Shuquan; Zheng, Xi; Yan, Qi; Dong, Jian-Wei; Yin, Tianpeng; Zhou, Zhixian; Tan, Ning‐Hua; Ding, Zhong‐Tao

doi:10.1016/j.phytol.2015.06.015

Cited by 20 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In pear extracts, most triterpenoid constituents except corosolic acid showed a weak contribution to the total antioxidant activity, perhaps due to a similar molecular skeleton. Nevertheless, other health benefits of triterpenoids have been demonstrated by many researchers [9,26,36].…”

Section: Resultsmentioning

confidence: 99%

Characterization and Quantification of Polyphenols and Triterpenoids in Thinned Young Fruits of Ten Pear Varieties by UPLC-Q TRAP-MS/MS

2019

View full text Add to dashboard Cite

Large quantities of thinned young pears, a natural source of bioactive compounds, are abandoned as agricultural by-products in many orchards. Hence, ten thinned young pear varieties were systematically investigated in terms of their chemical composition and antioxidant potential. Through ultra-performance liquid chromatography coupled with electrospray ionization triple quadrupole mass spectrometry (UPLC-Q TRAP-MS/MS), 102 polyphenols and 16 triterpenoids were identified and individually quantified within a short time using multiple reaction monitoring (MRM). Subsequently, the antioxidant capacities of these pears were determined with DPPH assays, and the correlation between total antioxidant activity and each component was analyzed. The results indicated that the bioactive compound content and antioxidant capacity in thinned pears were considerably high. Regarding chemical composition, chlorogenic acid, quinic acid and arbutin were the primary polyphenols and ursolic acid was the predominant triterpenoid, whereas 27 polyphenolic compounds, especially chlorogenic acid and most of the flavan-3-ols, were the main antioxidants in young pears. These findings should provide a scientific basis for the further use of pear fruit by-products.

show abstract

Section: Resultsmentioning

confidence: 99%

Characterization and Quantification of Polyphenols and Triterpenoids in Thinned Young Fruits of Ten Pear Varieties by UPLC-Q TRAP-MS/MS

2019

View full text Add to dashboard Cite

show abstract

“…In the branches and leaves, 20 terpenoids and two new terpenoids have been reported (36). The structure elucidation of these terpenoids was carried out using spectroscopic [infrared (IR), high resolution electrospray ionization mass spectrometry (HRESIMS), one and two-dimensional nuclear magnetic resonance (NMR)] and chemical analysis.…”

Section: Phytochemistry and Pharmacological Propertiesmentioning

confidence: 99%

Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

2021

View full text Add to dashboard Cite

The consumption of wild edible fruits for nutritional and medicinal benefits has been known for a long time. These naturally occurring fruit plants can thrive well under adverse climatic conditions and are being harvested and marketed locally. Pyrus pashia (P. pashia; Buch.-Ham. ex D. Don; family, Rosaceae), commonly known as 'wild edible or Himalayan pear' is one of such underutilized trees. It is widely distributed in temperate regions up to an altitude of 2,000 m in Western Himalaya. It has broad applications in traditional therapeutics for the treatment of diseases, such as eye infections, sore throat, diarrhea, stomach disorders and other infectious diseases. Chlorogenic acid, flavan-3-ols, gallic acid, tannins, alkaloids, hydroquinone, terpenoids and its isomers have been isolated and identified from the leaf, fruit, flower and bark portion of P. pashia. The phytochemicals present in the P. pashia tree may be responsible for the traditional beneficial health effects of the plant. Numerous scientific studies on P. pashia have validated the general uses of the plant by the native population; however, the data on its pharmacological properties and the mechanisms involved are insufficient. The present review aimed to provide a critical evaluation of the distribution, traditional uses, phytochemicals present, pharmacological activities and nutritional value of different plant parts of P. pashia. Detailed research is required on individual phytochemicals present and toxicological studies at the gene level. In-depth molecular studies may also confirm the various pharmaceutical claims for the development of novel pharmaceutical drugs and functional food products. Contents1. Introduction 2. Habitat and morphology 3. Traditional uses of various parts of P. pashia 4. Nutritive value 5. Phytochemistry and pharmacological properties 6. conclusion and future perspectives

show abstract

“…The fruits are used in the treatment of dyspepsia and dysmenorrhea. Flowers are used to lowering blood lipids and branches for diarrhea in Chinese folk medicine [11].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Phytochemical, Antioxidant and Antimicrobial Activities of Some Medicinal Plants from Kaski District of Nepal

Khanal¹,

Sharma²,

Pokharel³

et al. 2020

AJPS

View full text Add to dashboard Cite

Medicinal plants have been known to treat simple to life-threatening diseases in different communities of Nepal for many years. This study aims to analyze the phytochemicals as plant secondary metabolites, evaluate the antioxidant and antibacterial activities of Rubus ellipticus, Ziziphus mauritiana, Pyrus pashia, and Drynaria coronans extracts that are commonly being used as traditional medicine. Phytochemical analysis was performed to investigate the plant's secondary metabolites such as polyphenols, alkaloids, flavonoids, terpenoids, reducing sugar, glycosides, tannins, carotene, phytosterols, coumarins, saponins, and anthracenes. The methanol extracts of the plants were used to evaluate the in vitro antioxidant activity by using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical and the antibacterial activity against Staphylococcus aureus (ATCC 25923), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922) and Salmonella typhi (ATCC 14028) by the agar well diffusion method. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined by the Resazurin Microtiter Assay (REMA) method. Root extract of R. ellipticus was observed to have the highest antioxidant activity with IC 50 of 42.40 ± 1.5 μg/ml followed by the root extract of Z. mauritiana (IC 50 55.67 ± 7.41 μg/ml), leaf and bark extract of P. pashia (IC 50 58.33 ± 2.9 μg/ml) and tuber extract of D. coronans (IC 50 93.30 ± 5.19 μg/ml) as compared to the standard ascorbic acid with IC 50 of 28.44 ± 0.97 μg/ml. The plants were found active against Gram-positive Staphylococcus aureus with Zone of Inhibition (ZOI) for R. ellipicus 17 mm, P. pashia 12 mm, Z. mauritiana 9 mm and D. coronans 8 mm. The extracts exhibited no effect on all of the tested Gram-negative bacteria. The MIC and MBC of R. ellipticus and P. pashia were 3.125 mg/ml, 12.5 mg/ml, and 12.5 mg/ml, 25 mg/ml respectively.

show abstract

Terpenoids with cytotoxic activity from the branches and leaves of Pyrus pashia

Cited by 20 publications

References 25 publications

Characterization and Quantification of Polyphenols and Triterpenoids in Thinned Young Fruits of Ten Pear Varieties by UPLC-Q TRAP-MS/MS

Characterization and Quantification of Polyphenols and Triterpenoids in Thinned Young Fruits of Ten Pear Varieties by UPLC-Q TRAP-MS/MS

Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

Assessment of Phytochemical, Antioxidant and Antimicrobial Activities of Some Medicinal Plants from Kaski District of Nepal

Contact Info

Product

Resources

About