Terrestrial neuro-musculoskeletal rehabilitation and astronaut reconditioning: Reciprocal knowledge transfer

Stokes, María; Evetts, Simon; Hides, Julie

doi:10.1016/j.math.2016.10.003

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…It is known that the disorders seen in astronauts after a space mission are similar to terrestrial neuromuscular diseases in patients (Hides et al, 2017). Studies of the neuromuscular system plasticity in astronauts are beneficial to patients with similar disorders, and, vice versa, researches with patients may provide new options for the reconditioning of astronauts (Stokes et al, 2017). HMS is among the most untoward consequences of long-term orbital spaceflight.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

et al. 2019

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The hypogravity motor syndrome (HMS) is one of the deleterious impacts of weightlessness on the human body in orbital space missions. There is a hypothesis that disorders of musculoskeletal system as part of HMS arise in consequence of changes in spinal motor neurons. The study was aimed at bioinformatic analysis of transcriptome changes in lumbar spinal cords of mice after a 30-day spaceflight aboard biosatellite Bion-M1 (space group, S) and subsequent 7-day readaptation to the Earth’s gravity (recovery group, R) when compared with control mice (C group) housed in simulated biosatellite conditions on the Earth. Gene ontology and human phenotype ontology databases were used to detect biological processes, molecular functions, cellular components, and human phenotypes associated with HMS. Our results suggest resemblance of molecular changes developing in space orbit and during the postflight recovery to terrestrial neuromuscular disorders. Remarkably, more prominent transcriptome changes were revealed in R vs. S and R vs. C comparisons that are possibly related to the 7-day recovery period in the Earth’s gravity condition. These data may assist with establishment of HMS pathogenesis and proposing effective preventive and therapeutic options.

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Section: Discussionmentioning

confidence: 99%

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

et al. 2019

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“…Parallels can be drawn between principles of physiotherapy management for people with various conditions on Earth (Hides et al 2016a(Hides et al , 2017Payne,et al, 2007). However, physiotherapy management of astronauts does present some unique challenges.…”

Section: Discussionmentioning

confidence: 99%

“…Studying astronauts allows measurements and interventions to be trialled before, during and after exposure to microgravity. Parallels with deconditioning in areas of terrestrial rehabilitation, such as sports injuries, neurological disorders and intensive care, are discussed by Hides et al (2017). Possible solutions to the challenges of conducting research in postflight reconditioning are discussed by Beard and Cook (2017).…”

Section: Parallels With Terrestrial Populationsmentioning

confidence: 99%

The role of physiotherapy in the European Space Agency strategy for preparation and reconditioning of astronauts before and after long duration space flight

Lambrecht

Petersen

Weerts

et al. 2017

Musculoskeletal Science and Practice

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Spaceflight and exposure to microgravity have wide-ranging effects on many systems of the human body. At the European Space Agency (ESA), a physiotherapist plays a key role in the multidisciplinary ESA team responsible for astronaut health, with a focus on the neuromusculoskeletal system. In conjunction with a sports scientist, the physiotherapist prepares the astronaut for spaceflight, monitors their exercise performance whilst on the International Space Station (ISS), and reconditions the astronaut when they return to Earth. This clinical commentary outlines the physiotherapy programme, which was developed over nine longduration missions. Principles of physiotherapy assessment, clinical reasoning, treatment programme design (tailored to the individual) and progression of the programme are outlined.Implications for rehabilitation of terrestrial populations are discussed. Evaluation of the reconditioning programme has begun and challenges anticipated after longer missions, e.g. to Mars, are considered. Key WordsPhysiotherapy; microgravity; spaceflight; astronaut reconditioning; exercise; low back pain 4 IntroductionThe requirements of the human body, in particular the neuro-musculoskeletal system, are very different in space than on Earth. Interestingly, physiological spaceflight data suggest that it is more difficult to return to gravity than to adapt to microgravity conditions (Payne et al 2007). On Earth, the line of gravity normally passes through the ventral part of the L3 vertebral body (Richter & Hebgen, 2006), ensuring optimal load transfer). In microgravity, musculoskeletal adaptations are appropriate to that environment but this has major effects on muscle function and posture. Astronauts move in a predominantly flexed position and the centre of mass shifts posteriorly (Baroni et al, 2001), with increased recruitment of flexor muscles and a loss of extensors (Fitts et al 2001; Fitts et al 2000). A shift of muscle fibres types from tonic (type 1) to phasic (type 2) occurs (Fitts 2001). Graviceptors, which are sensory receptors that contribute to providing a neural representation of the direction of gravity, with respect to the gravity vector (Binder 2009), no longer function in microgravity.The astronaut therefore receives less information about his/her posture and has to rely on vision and feedback from dynamic receptors.Prolonged microgravity has negative effects on muscle strength and endurance, motor control, coordination and balance (Layne et al, 2001), which may place the astronaut at higher risk of injury. In the spine, primarily lumbar, intervertebral discs absorb more water (hyperhydration) than on Earth (Belavy et al 2016), which can be associated with low back pain (LBP) inflight but is short-lived and has been reported in 70% of astronauts without a history of LBP and 100% of those with a history of LBP (Pool-Goodzwaard et al 2015). The effects of microgravity on the intervertebral disc must be considered to allow safe re-loading of the spine postflight, as the astronaut must readapt...

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“…Future exploration missions of up to three years, such as to Mars, will be even more challenging to recover from and require research to develop optimal reconditioning programmes. Inflight 'Preconditioning' programmes may also be needed inflight, to prepare for planetary surface exploration during these missions [30].…”

Section: Future Directionmentioning

confidence: 99%

Postflight reconditioning for European Astronauts – A case report of recovery after six months in space

Petersen

Lambrecht

Scott

et al. 2017

Musculoskeletal Science and Practice

Self Cite

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Terrestrial neuro-musculoskeletal rehabilitation and astronaut reconditioning: Reciprocal knowledge transfer

Cited by 6 publications

References 24 publications

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

Bioinformatic Study of Transcriptome Changes in the Mice Lumbar Spinal Cord After the 30-Day Spaceflight and Subsequent 7-Day Readaptation on Earth: New Insights Into Molecular Mechanisms of the Hypogravity Motor Syndrome

The role of physiotherapy in the European Space Agency strategy for preparation and reconditioning of astronauts before and after long duration space flight

Postflight reconditioning for European Astronauts – A case report of recovery after six months in space

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