Tertiary Syphilis of the Lung and its Diagnosis

Morgan, A. D.; Lloyd, W. E.; Price-Thomas, Clement

doi:10.1136/thx.7.2.125

Cited by 28 publications

(10 citation statements)

References 9 publications

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“…More recently, another 3 cases have been reported as secondary syphilis with pulmonary lesions [3][4][5], and 2 of them are the only cases with solitary tumor-like pulmonary lesions [3,5], though without histopathology. Two types of lesions in pul monary syphilis, the gummatous and fibrotic lesions have been described earlier [6], and gumma is assumed to be the only spe cific histological change in pulmonary syphilis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Secondary Syphilis with a Solitary Pulmonary Lesion

Kurumaji¹,

Katoh²,

Ohtaki³

et al. 1987

Dermatology

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This study describes a case of secondary syphilis with a papular eruption and penile ulceration. A chest roentgenogram showed a solitary lesion in the left middle lung field. Histological examination revealed epithelioid cell granuloma in both the penile ulcer and the lung lesion. After antisyphilitic treatment, the lung lesion shrunk remarkably and at the same time the skin eruption and the systemic symptoms also improved.

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Section: Discussionmentioning

confidence: 99%

A Case of Secondary Syphilis with a Solitary Pulmonary Lesion

Kurumaji¹,

Katoh²,

Ohtaki³

et al. 1987

Dermatology

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“…The disease tends to attack the middle and lower lobes of the lungs. 5 Microscopically, a heavy inflammatory infiltrate of histiocytes, plasma cells and lymphocytes may be seen, as well as small foci of necrosis. 4 Typical gummata have a centre of pale grey or yellow dry necrosis encased by a fibrous capsule from which irregular strands of fibrotic lung extend into and distort the surrounding tissue.…”

mentioning

confidence: 99%

“…Some patients have no respiratory symptoms. 5 Tracheobronchial syphilis affects limited sections of the airways; if it is severe, subsequent healing and fibrosis can lead to distortion of bronchus and adjacent lung. 4 Luetic pneumonia is chronic and involves both the airspace and interstitium.…”

mentioning

confidence: 99%

“…4 Typical gummata have a centre of pale grey or yellow dry necrosis encased by a fibrous capsule from which irregular strands of fibrotic lung extend into and distort the surrounding tissue. 4,5 These gummata can cause necrosis of the alveolar wall and destruction of elastic tissue, erode into adjacent bronchi and lead to cavitation.…”

mentioning

confidence: 99%

“…4−6 Most cases of tertiary syphilis in the literature were definitively diagnosed by pathological findings of tracheobronchial syphilis, luetic pneumonia or typical gummata (syphilitic granulomas), and the absence of acid-fast bacilli on autopsy or following lobectomy or pneumonectomy. 4,5,7 The clinical presentation of pulmonary syphilis varies and includes cough, hemoptysis, dyspnea and chest pain. Some patients have no respiratory symptoms.…”

mentioning

confidence: 99%

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Necrotic pulmonary nodules in secondary syphilis

McCready¹,

Skrastins²,

Downey³

et al. 2010

Canadian Medical Association Journal

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Cytologic diagnosis of syphilitic pleuritis: A case report

Zaharopoulos

Wong

1997

Diagn. Cytopathol.

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We report on a case of a 68‐yr‐old man with secondary syphilis diagnosed by biopsy of skin lesions, who concomitantly suffered from left lower lobe pneumonia with associated pleuritis. Cytologic examination of the pleural fluid was diagnostic of syphilis, not only by the characteristic cytomorphology but also by demonstration of spirochetes by the May‐Grünwald‐Giemsa (MGG) and Steiner staining methods. This suggests that the pneumonia was also syphilitic. The patient was seropositive for HIV‐1, but this probably did not contribute to the thoracic manifestations of syphilis, as there was no evidence of immunodeficiency by the CD4/CD8 T lymphocyte count. This is the second reported demonstration of Treponema pallidum in a pleural fluid, and the first diagnosed by cytopathologic examination. Diagn. Cytopathol. 16:35–38, 1997. © 1997 Wiley‐Liss, Inc.

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Tertiary Syphilis of the Lung and its Diagnosis

Cited by 28 publications

References 9 publications

A Case of Secondary Syphilis with a Solitary Pulmonary Lesion

A Case of Secondary Syphilis with a Solitary Pulmonary Lesion

Necrotic pulmonary nodules in secondary syphilis

Cytologic diagnosis of syphilitic pleuritis: A case report

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