Test-Retest Reliability of Memory Task Functional Magnetic Resonance Imaging in Alzheimer Disease Clinical Trials

Atri, Alireza; O’Brien, Jacqueline; Sreenivasan, Aishwarya; Rastegar, Sarah; Salisbury, Sibyl L.; DeLuca, Amy; O’Keefe, Kelly; LaViolette, Peter S.; Rentz, Dorene M.; Locascio, Joseph J.; Sperling, Reisa A.

doi:10.1001/archneurol.2011.94

Cited by 34 publications

(33 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To avoid learning effects, the novel face-name pairs and repeated face-name pairs used at baseline and at week 24 were different. Previous work from our group has shown high reliability between scans in healthy young adults, healthy elderly participants, individuals with mild cognitive impairment, and in AD patients [10,24,27]. As reported in Putcha et al [24], we found no associations between change in postscan memory performance and change in BOLD activity in older normal controls (CDR 0) and subjects with mild cognitive impairment (CDR 0.5).…”

Section: Methodssupporting

confidence: 65%

“…In particular, fMRI potentially manifests signals of effects at the synaptic/local field potential levels, and these signals are likely to be detectable much earlier than changes in behavior in order to guide drug discovery, selection and therapeutic trial efforts. While the current results do not support accuracy at the level of the individual, they are nonetheless encouraging as they support the detection of a potential signal at the group level with N’s that are modest enough to support their investigation in small early-phase/proof-of-concept AD trials [1,24]. …”

Section: Discussionmentioning

confidence: 75%

“…Important to the feasibility of using cognitive tests and fMRI as reliable measures in clinical trials is that there be no learning effect over time. The present paradigm has been shown to have high reliability across time and the stimuli used at baseline and the week-24 visits were different [1,10,24]. Additionally, the neuropsychological measures utilized in this study have both high validity and reliability across time in mild AD dementia [20,34,35].…”

Section: Discussionmentioning

confidence: 99%

“…This task was chosen based on its extensive use over the past decade in probing the functional neuroanatomical specificity of associative memory encoding processes [1,3,4,10,12,21,22,23,24,25]. The face-name paradigm is also highly clinically relevant; it is a cross-modal associative memory paradigm that compares the encoding of novel face-name pairs to viewing highly familiarized repeated face-name pairs, as difficulty remembering proper names remains the most common complaint of older individuals [26].…”

Section: Methodsmentioning

confidence: 99%

“…With promising therapies for Alzheimer’s disease (AD) entering clinical trials, functional magnetic resonance imaging (fMRI) has potential as a complementary biomarker to provide an early signal of effect or efficacy, particularly in early-phase proof-of-concept human studies [1,2]. Group level differences in regionally specific fMRI activity associated with aging, mild cognitive impairment, AD, and memory-affecting drugs have been observed [3,4,5,6,7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Tracking Cognitive Change over 24 Weeks with Longitudinal Functional Magnetic Resonance Imaging in Alzheimer’s Disease

et al. 2012

Self Cite

View full text Add to dashboard Cite

Background: Previous studies have revealed that functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal in specific brain regions correlates with cross-sectional performance on standardized clinical trial measures in Alzheimer’s disease (AD); however, the relationship between longitudinal change in fMRI-BOLD signal and neuropsychological performance remains unknown. Objective: To identify changes in regional fMRI-BOLD activity that tracks change in neuropsychological performance in mild AD dementia over 6 months. Methods: Twenty-four subjects (mean age 71.6) with mild AD dementia (mean Mini Mental State Examination 21.7, Global Clinical Dementia Rating 1.0) on stable donepezil dosing participated in two task-related fMRI sessions consisting of a face-name paired associative encoding memory paradigm 24 weeks apart during a randomized placebo-controlled pharmaco-fMRI drug study. Regression analysis was used to identify regions where the change in fMRI activity for Novel > Repeated stimulus contrast was associated with the change scores on postscan memory tests and the Free and Cued Selective Reminding Test (FCSRT). Results: Correlations between changes in postscan memory accuracy and changes in fMRI activity were observed in regions including the angular gyrus, parahippocampal gyrus, inferior frontal gyrus and cerebellum. Correlations between changes in FCSRT-free recall and changes in fMRI were observed in regions including the inferior parietal lobule, precuneus, hippocampus and parahippocampal gyrus. Conclusion: Changes in encoding-related fMRI activity in regions implicated in mnemonic networks correlated with changes in psychometric measures of episodic memory retrieval performed outside the scanner. These exploratory results support the potential of fMRI activity to track cognitive change and detect signals of short-term pharmacologic effect in early-phase AD studies.

show abstract

Section: Methodssupporting

confidence: 65%

Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Tracking Cognitive Change over 24 Weeks with Longitudinal Functional Magnetic Resonance Imaging in Alzheimer’s Disease

et al. 2012

Self Cite

View full text Add to dashboard Cite

show abstract

MRI and Functional MRI

Bigler

Allen

Stimac

2012

Neuroimaging in Forensic Psychiatry

View full text Add to dashboard Cite

Bringing memory fMRI to the clinic: Comparison of seven memory fMRI protocols in temporal lobe epilepsy

Towgood

Barker

Cáceres

et al. 2015

Human Brain Mapping

View full text Add to dashboard Cite

AbstractfMRI is increasingly implemented in the clinic to assess memory function. There are multiple approaches to memory fMRI, but limited data on advantages and reliability of different methods. Here, we compared effect size, activation lateralisation, and between‐sessions reliability of seven memory fMRI protocols: Hometown Walking (block design), Scene encoding (block design and event‐related design), Picture encoding (block and event‐related), and Word encoding (block and event‐related). All protocols were performed on three occasions in 16 patients with temporal lobe epilepsy (TLE). Group T‐maps showed activity bilaterally in medial temporal lobe for all protocols. Using ANOVA, there was an interaction between hemisphere and seizure‐onset lateralisation (P = 0.009) and between hemisphere, protocol and seizure‐onset lateralisation (P = 0.002), showing that the distribution of memory‐related activity between left and right temporal lobes differed between protocols and between patients with left‐onset and right‐onset seizures. Using voxelwise intraclass Correlation Coefficient, between‐sessions reliability was best for Hometown and Scenes (block and event). The between‐sessions spatial overlap of activated voxels was also greatest for Hometown and Scenes. Lateralisation of activity between hemispheres was most reliable for Scenes (block and event) and Words (event). Using receiver operating characteristic analysis to explore the ability of each fMRI protocol to classify patients as left‐onset or right‐onset TLE, only the Words (event) protocol achieved a significantly above‐chance classification of patients at all three sessions. We conclude that Words (event) protocol shows the best combination of between‐sessions reliability of the distribution of activity between hemispheres and reliable ability to distinguish between left‐onset and right‐onset patients. Hum Brain Mapp 36:1595–1608, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

show abstract

Test-Retest Reliability of Memory Task Functional Magnetic Resonance Imaging in Alzheimer Disease Clinical Trials

Cited by 34 publications

References 44 publications

Tracking Cognitive Change over 24 Weeks with Longitudinal Functional Magnetic Resonance Imaging in Alzheimer’s Disease

Tracking Cognitive Change over 24 Weeks with Longitudinal Functional Magnetic Resonance Imaging in Alzheimer’s Disease

MRI and Functional MRI

Bringing memory fMRI to the clinic: Comparison of seven memory fMRI protocols in temporal lobe epilepsy

Contact Info

Product

Resources

About