Test-Retest Reliability of Multiple Sleep Latency Test in Diagnosis of Narcolepsy

Seong, Min Jae; Choi, Soo Joo; Hong, Seung Bong; Joo, Eun Yeon

doi:10.13078/jsm.200033

Cited by 5 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firstly, our results of the follow-up MSLT findings in NT 2 groups is in same line with the previous studies [3][4][5][6][7][10][11][12][13]. The proportion of maintaining diagnosis in NT2 was only about 50%.…”

Section: Discussionsupporting

confidence: 92%

“…Central hypersomnolence disorders are excessive daytime sleepiness in the absence of nocturnal sleep pathology or insufficient sleep [1][2][3][4][5], including narcolepsy with or without cataplexy and idiopathic hypersomnia (IH) [6]. Cataplexy is a symptom mainly caused by hypocretin/orexin deficiency and is an essential criterion for classifying narcolepsy types.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Different Course of Narcolepsy Diagnosed by Multiple Sleep Latency Test: A Single Center Experience

Chun¹,

Kim²,

Kim³

et al. 2022

Sleep Med Res

View full text Add to dashboard Cite

Background and Objective Several studies have raised questions about determining the diagnosis of the narcolepsy using multiple sleep latency test (MSLT). In this study, we investigated the diagnostic change in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2) using MSLT with long-term interval.Methods In this retrospective study, the demographic characteristics, polysomnography (PSG), and MSLT parameters were compared at the baseline between the NT1 and NT 2 patients. Then, MSLT re-tests were conducted with a mean follow-up of 8.48 years in patients with NT 1 and 7.05 years with NT 2.Results Seventy-four patients (58 with NT1 and 16 with NT2) were investigated in this study. At the baseline, demographic data showed a larger body mass index value, more sleep paralysis, and hypnogogic hallucination in NT 1 compared to NT 2. Also, at baseline MSLT, shorter mean sleep latency and higher number of sleep onset rapid eye movement periods (SOREMPs) were observed in the NT 1 than those of the NT 2. On follow-up MSLT, 6.9% (n = 4) patients with NT1 and 50% (n = 8) patients with NT2 did not satisfy the previous diagnosis. Furthermore, in all the groups who had the change in repeated-MSLT, the groups with less than 2 SOREMPs observed to be accompanied by negative MSL at follow-up.Conclusions The result of MSLT was observed not to be stable in the diagnosis of NT 2 at the study. Therefore, it is recommended to repeat MSLT at regular intervals and do a prospective multi-site survey for the accurate confirmation of a diagnosis of central hypersomnia.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Different Course of Narcolepsy Diagnosed by Multiple Sleep Latency Test: A Single Center Experience

Chun¹,

Kim²,

Kim³

et al. 2022

Sleep Med Res

View full text Add to dashboard Cite

show abstract

“…Narcolepsy has been included in the RID program as a target for the copayment assistance policy since 2009, which is supported by the NHIS of South Korea. 15 Patients registered in the RID program make less out-of-pocket payments (10% of the total medical cost) than usual NHIS subscribers (20%–60% of the total cost). To be registered for the RID program, confirmative test results and clinical symptoms must be recorded by physicians and reassessed by administrators.…”

Section: Methodsmentioning

confidence: 99%

“…Despite the increase in clinical and social interest in narcolepsy during recent decades, 15 epidemiological data on narcolepsy are sparse in South Korea. One study using a screening telephone interview and confirmatory laboratory investigation (PSG, HLA typing) of 20,407 students (14–19 years old) in Seongnam and Yongin found a narcolepsy prevalence of 34/100,000 among South Korean adolescents, but the prevalence rates in other age groups have not been investigated.…”

Section: Introductionmentioning

confidence: 99%

National Estimates of Narcolepsy in Korea

2023

View full text Add to dashboard Cite

Background and Purpose Epidemiological data on narcolepsy are rare in South Korea. We aimed to provide an overview of the burden of narcolepsy and its temporal trend in South Korea. Methods Patients with narcolepsy were identified by their registration in the Rare and Intractable Disease (RID) register and the Health Insurance Review and Assessment database. Individuals registered in the RID program with the code V234 were considered as having ‘definite narcolepsy’, while those who claimed health insurance with G47.4 as the primary diagnostic code were considered as having ‘probable narcolepsy’. We estimated the annual prevalence, incidence, and medical costs of narcolepsy between 2010 and 2019. Results The prevalence of definite narcolepsy was 8.4/100,000 in 2019, peaking at 32.0/100,000 in those aged 15–19 years. The prevalence was higher in males, with a relative risk of 1.72. The prevalence has increased over the past 6 years, with an average annual growth rate (AAGR) of 12.2%. The prevalence of probable narcolepsy was 10.7/100,000 in 2019. The incidence of definite narcolepsy increased up to 1.3/100,000 in 2019 with an AAGR of 7.1%. Annual medical expenditure for definite narcolepsy gradually increased up to 4.1 billion KRW in 2019, with a compound annual growth rate of 11.9%. Conclusions This study has provided the first nationwide estimates for narcolepsy in South Korea. The prevalence of diagnosed narcolepsy in South Korea was at the low end of the range of narcolepsy prevalence rates reported for other countries. However, the prevalence and incidence have been steadily increasing over the past decade.

show abstract

“…Nevertheless, the validity of the MSLT has been questioned for NT2 and idiopathic hypersomnia [26,[33][34][35][36][37][38][39]. This article reviews studies in which the diagnosis of NT2 and idiopathic hypersomnia has been changed by repeated MSLTs and discusses the potential causes and countermeasures for these diagnostic shifts.…”

Section: Introductionmentioning

confidence: 99%

Challenges in Diagnosing Narcolepsy and Idiopathic Hypersomnia

et al. 2023

View full text Add to dashboard Cite

Narcolepsy and idiopathic hypersomnia are central disorders of hypersomnolence accompanied by excessive daytime sleepiness, which are not caused by nocturnal sleep disturbance, sleep deficiency, or circadian rhythm sleep disorders. Several studies have questioned the repeatability of the Multiple Sleep Latency Test (MSLT) in type 2 narcolepsy (NT2) patients. After two or more repeated MSLTs, the diagnosis of type 1 narcolepsy (NT1) is maintained in more than 90% of cases, while only half of the NT2 patients retain their original diagnosis. The diagnosis of NT2 may shift to idiopathic hypersomnia based on the MSLT results, making the differential diagnosis of NT2 and idiopathic hypersomnia particularly challenging. Therefore, this study suggests the need for new tests in addition to the MSLT for diagnostic consistency in NT2 and idiopathic hypersomnia.

show abstract

Test-Retest Reliability of Multiple Sleep Latency Test in Diagnosis of Narcolepsy

Cited by 5 publications

References 13 publications

Different Course of Narcolepsy Diagnosed by Multiple Sleep Latency Test: A Single Center Experience

Different Course of Narcolepsy Diagnosed by Multiple Sleep Latency Test: A Single Center Experience

National Estimates of Narcolepsy in Korea

Challenges in Diagnosing Narcolepsy and Idiopathic Hypersomnia

Contact Info

Product

Resources

About