Test‐retest repeatability of microperimetry in patients with retinitis pigmentosa caused by mutations in RPGR

CRB1-Associated Retinal Dystrophies: A Prospective Natural History Study in Anticipation of Future Clinical Trials

“…39 Fundus-tracking perimetry, also known as microperimetry, is a commonly used tool for monitoring disease progression and for assessing treatment efficacy in trials involving other RDs, such as Stargardt disease, choroideremia and X-linked RP. 32,40,41,42 In these RDs, subtle changes in the retina over short periods of time were detectable on microperimetry, preceding detection on conventional parameters. 27,43 Similar results were found in our cohort, in which we detected a significant decline in macular sensitivity between visits, while no significant decline in BCVA was detected in the 2-year period.…”

Estimation of current and post-treatment retinal function in chronic central serous chorioretinopathy using artificial intelligence

“…This approach could also be applied to obtain an estimate of function in patients overchallenged with psychophysical testing or at clinical sites without dedicated FCP devices. In terms of accuracy, MAE estimates for the inference of point-wise retinal sensitivity are in a similar range to the retest-reliability of FCP 20,21 , and similar to AI-based structure-function analyses in other retinal diseases [8][9][10]22 . Importantly, the predictions were overall unbiased.…”

Characterization of Retinal Function Using Microperimetry-Derived Metrics in Both Adults and Children With RPGR-Associated Retinopathy

“…A previous study investigating progression rates using full-field Octopus perimetry found an increased rate of progression (although not statistically significant) in the Exon 1-14 sub-group, although their findings may have been confounded by an age disparity between the two molecularly distinct cohorts. (8) Another study in the Asian population, also supported that patients with variants in exons 1-14 retained less visual acuity than patients with ORF15 variants and deteriorated faster. (22) Similar findings were identified in a cohort of Japanese patient (n=14).…”

“…Given the early onset of visual loss in XLRP, this lends it well to detect changes in childhood. A recent report (8) utilising the MAIA perimeter reported good test-retest reliability for testing in an XLRP-RPGR cohort (with no data provided on the age of these subjects -but likely to have been adults only).They found greater variability between the first two tests a subject performs than between tests 2 and 3, indicating a learning phenomenon, resulting in the recommendation to perform three baseline assessments in cases of clinical trials and use the final macular sensitivity result as baseline. The ICC results for MS and the volumetric indices in our study confirms high levels of test-retest reliability for MP measurements on the Nidek MP-1 perimeter.…”