Test–retest study of fMRI signal change evoked by electroacupuncture stimulation

Kong, Jian; Gollub, Randy L.; Webb, Julia Megan; Kong, Jiang-Ti; Vangel, Mark; Kwong, Kenneth K.

doi:10.1016/j.neuroimage.2006.10.019

Cited by 125 publications

(127 citation statements)

References 51 publications

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“…working memory and learning indicating that individual difference was not significant across subjects (10)(11)(12)(13)(14). However, several acupuncture studies inferred that the influence of individual difference should be taken into consideration (17). This study detected the differences of DID between the visual and the acupuncture stimulation.…”

Section: Discussionmentioning

confidence: 69%

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Sun

Qin

Dong

et al. 2010

Magnetic Resonance Imaging

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Purpose: To evaluate the extent of individual differences of functional MRI (fMRI) signal changes induced by acupuncture stimulation. Materials and Methods:Acupuncture at ST36 and checkerboard stimulation was applied to 16 subjects. We calculated the mean distance using beta values in a generalized linear model (GLM) analysis and employed it to study the group homogeneity by detecting the outliers.Results: A more significant individual difference was presented in acupuncture stimulation compared with visual stimulation through evaluation of the mean distance. From the group results, we found that the activations were more significant in the homogeneous group results. Combining the behavior and fMRI results, there was no direct correlation between deqi index and mean distance in acupuncture stimulation. The deqi index of the outlier was in the normal range and did not differ significantly from others. Conclusion:Traditional group results without removing outliers were not sensitive enough to detect the real acupuncture effect. We suggest that individual difference should be taken into consideration for future acupuncture studies. Also, group analysis paralleled with individual analysis is critical for a full understanding of acupuncture effects.

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Section: Discussionmentioning

confidence: 69%

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Sun

Qin

Dong

et al. 2010

Magnetic Resonance Imaging

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“…Recently, functional magnetic resonance imaging (fMRI) has been used to investigate the neurobiological mechanisms underlying acupuncture needle manipulation [11,20,22,24,25,29,[42][43][44][45]. It is commonly reported that manual acupuncture needle manipulation induces fMRI signal change in widespread neuronal networks.…”

Section: Discussionmentioning

confidence: 99%

“…Treatment lasted about 30 minutes. Immediately following acupuncture treatment, subjects used the Subjective Acupuncture Sensation Scale (SASS) to quantify their sensations of stabbing, throbbing, tingling, burning, heaviness, fullness/distention, numbness, soreness, and aching, and other feelings about the stimulated acupoint [17,20]. This set of deqi descriptors is based on sensations described in the more recent Traditional Chinese Medicine literature [18].…”

Section: Acupuncture Administrationmentioning

confidence: 99%

“…Functional magnetic resonance imaging (fMRI) and Positron Emission Tomography (PET) studies of acupuncture needle manipulation [3,11,[20][21][22]24,25,29,31,[42][43][44] and acupuncture analgesia [5,45,46] demonstrate involvement of these neuronal networks during acupuncture. Additionally, there is strong evidence that acupuncture analgesia is mediated at least in part by opioid systems [4,6,26,32].…”

Section: Introductionmentioning

confidence: 99%

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A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia

Dougherty

Kong

Webb

et al. 2008

Behavioural Brain Research

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Functional neuroimaging studies suggest that a lateral network in the brain is associated with the sensory aspects of pain perception while a medial network is associated with affective aspects. The highest concentration of opioid receptors is in the medial network. There is significant evidence that endogenous opioids are central to the experience of pain and analgesia. We applied an integrative multimodal imaging approach during acupuncture. We found functional magnetic resonance imaging signal changes in the orbitofrontal cortex, insula, and pons and [11C]diprenorphine positron emission tomography signal changes in the orbitofrontal cortex, medial prefrontal cortex, insula, thalamus, and anterior cingulate cortex. These findings include brain regions within both the lateral and medial pain networks.

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“…Variability in needling technique, deqi sensations, design paradigm, differences in neruoimaging hardware and software, as well as data post-processing methods [62,63], may all account for many of the reported differences in brain response. Therefore, it may be helpful to define a standardized reporting system to describe details of acupuncture manipulations [64].…”

Section: Further Directions For Acupuncture Neuroimaging Researchmentioning

confidence: 99%

Spatiotemporal Modulation of Central Neural Pathway Underlying Acupuncture Action: A Systematic Review

Bai¹,

Qin²,

Liang³

et al. 2009

CMIR

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Acupuncture, an ancient therapeutic technique, is currently gaining popularity as an important modality of alternative and complementary medicine in the West world. Concurrently, scientific interests in exploring whether acupuncture is therapeutically effective are raised alongside those about the means by which it may operate. Modern neuroimaging techniques such as functional magnetic resonance imaging, positron emission tomography, electroencephalography, and magnetoencephalography provide a means to safely monitor brain activity in humans. In this review, we have summarized evidence derived from the neuroimaging studies and tried to elucidate the neurophysiological correlates of acupuncture. Previous investigations on the neural responses to acupuncture mainly focus on its acute effects and explore the correlation between the specific acupoints and cortical activations only in the spatial domain. However, abundant clinical reports and psychophysical analysis suggest the kinetics of acupuncture is longer acting as a function of time. Consequentially, an accurate interpretation of acupuncture actions depends on how effectively we can characterize the nature of temporal variations underlying neural activities, rather than simply detect the occurrence of such changes. This emerging picture indicates that both designing paradigms and statistical models involved in acupuncture studies should be applied with great care.

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Test–retest study of fMRI signal change evoked by electroacupuncture stimulation

Cited by 125 publications

References 51 publications

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

Evaluation of group homogeneity during acupuncture stimulation in fMRI studies

A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia

Spatiotemporal Modulation of Central Neural Pathway Underlying Acupuncture Action: A Systematic Review

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