Achieving system-level dependability is a demanding task. The manifold requirements and dependability threats can no longer be statically addressed at individual abstraction layers. Instead, all components of future multi-processor systems-on-chip (MPSoCs) have to contribute to this common goal in an adaptive manner. In this paper we target a generic heterogeneous MPSoC that combines general purpose processors along with dedicated application-specific hard-wired accelerators, finegrained reconfigurable processors, and coarse-grained reconfigurable architectures. We present different reactive and proactive measures at the layers of the runtime system (online resource management), system architecture (global communication), micro architecture (individual tiles), and gate netlist (tile-internal circuits) to address dependability threats.