Testicular cytotoxicity of DA-125, a new anthracycline anticancer agent, in rats

Kim, Jong-Choon; Kim, Kwang-Hyeon; Chung, Moon-Koo

doi:10.1016/s0890-6238(99)00028-3

Cited by 62 publications

(47 citation statements)

References 19 publications

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“…Cellular, and molecular toxic effects of this antitumoral drug on gonads during spermatogenesis have been evaluated in comprehensive studies. [11][12][13][14] Oligospermia was observed in many adult men even after successful treatment with MTX. [6,[14][15][16][17] Changes in dimensions of primary, and secondary spermatocytes alter the size of spermatids, and Leydig cells.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13][14] Oligospermia was observed in many adult men even after successful treatment with MTX. [6,[14][15][16][17] Changes in dimensions of primary, and secondary spermatocytes alter the size of spermatids, and Leydig cells. [18] As indicated in available studies MTX damages seminiferous tubuli of testis with resultant decrease in sperm counts, and harmful effects on sperm DNA.…”

Section: Discussionmentioning

confidence: 99%

“…Studies performed have demonstrated that MTX exerts its cellular effects by decreasing antioxidative effectiveness of cells, and exposes them to deleterious effects of reactive oxygen species (ROS) leading to destructive changes in testicular tissue, and germ cells. [14][15][16][17] As demonstrated in many studies, MTX causes atrophic changes in seminiferous tubuli, and apoptosis of germinal cells. [8] In studies performed in mice, and rats, MTX had decreased testicular weight, and sperm counts, increased number of sperm head abnormalities, and damaged DNAs of seminiferous tubuli, and spermatozoa.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Sayılmaz

Karabulut

Özgörgülü

2016

Turkish Journal of Urology

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Objective: Methotrexate (MTX) leads to acute toxic side effects in tissues or organs containing rapidly dividing cells such as seminiferous tubules. In this study, we investigated the protective effects of vitamin C against MTX-induced injury in rat testis. Material and methods:A total of 31 rats were divided into 4 groups, including the control group. The study was completed within 4 weeks and the rats received daily doses of 2 mL/kg SF, 100 mg/kg vitamin C and 10 mg/kg/day MTX i.p according to their groups. The mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were determined by histologic examination of each group. Results:The vitamin C + MTX group showed more similarity with the control group. Statistically significant results were achieved between groups as for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score. When compared with the group which received vitamin C after MTX therapy, values for mean seminiferous tubular diameter, germinal epithelial cell thickness, and mean testicular biopsy score were significantly higher in the group which received vitamin C before initiation of MTX therapy. Conclusion:Vitamin C decreased MTX-induced testicular histological injuries, especially when used before MTX therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The histopathological evaluation of healing effects of vitamin C administered before methotrexate therapy on testicular injury induced by methotrexate

Sayılmaz

Karabulut

Özgörgülü

2016

Turkish Journal of Urology

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“…The number of testicular sperm heads, which is known as a clear index of testicular cytotoxicity, correlated well with histopathological findings. It was previously reported that evaluation of testicular sperm head counts seems to be a good indicator of spermatogenic damages and that the number of testicular sperm heads corresponds to the number of elongate spermatids in the testis [29].…”

Section: Discussionmentioning

confidence: 99%

The effect of zinc oxide nanoparticles on mouse spermatogenesis

Talebi

Khorsandi

Moridian³

2013

J Assist Reprod Genet

127

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Objective To evaluate the effects of zinc oxide nanoparticles on mouse spermatogenesis. Methods Thirty two adult male NMRI mice were used. Experimental Groups (ZNP-1-ZNP-3) received one of the following treatments daily for 35 days: 5, 50 and 300 mg/kg zinc oxide nanoparticles respectively. Control group received only distilled water. Epididymal sperm parameters, testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the zinc oxide nanoparticles effects on testis. Results Epididymal sperm parameters including sperm number, motility and percentage of abnormality were significantly changed in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.01). Histopathological criteria such as epithelial vacuolization, sloughing of germ and detachment were significantly increased in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p<0.001). 300 mg/kg zinc oxide nanoparticles induced formation of multinucleated giant cells in the germinal epithelium. 50 and 300 mg/kg zinc oxide nanoparticles also caused a significant decrease in seminiferous tubule diameter, seminiferous epithelium height and maturation arrest (p<0.001). Conclusion Zinc oxide nanoparticles act as testicular toxicant and further studies are needed to establish its mechanism of action upon spermatogenesis.

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“…Only basal cells such as spermatogonia and Sertoli cell nuclei were seen in many tubules. Germ cell dissociation and sloughing into the lumen has been previously reported [22]. In some tubules, spermatocytes with multiple nuclei were visible suggesting degenerative transformation.…”

Section: Discussionmentioning

confidence: 68%