Testicular function after torsion of the spermatic cord

Visser, A. J.; Cf, Heyns

doi:10.1046/j.1464-410x.2003.04307.x

Cited by 253 publications

(191 citation statements)

References 31 publications

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“…1,2 Prompt surgical exploration and detorsion can contribute to salvaging the testis in 42-88% of cases. 3,4 Even if the ipsilateral testis is salvaged, permanent damage can occur, depending on the degree and duration of the torsion.…”

Section: Introductionmentioning

confidence: 99%

The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury

Ozmerdiven

Çoşkun

Kaygısız

et al. 2017

CUAJ

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Cite as: Can Urol Assoc J 2017;11(1-2):E19-25. http://dx.doi.org/10.5489/cuaj.3872 Published online January 12, 2017 AbstractIntroduction: Nitric oxide (NO) plays an important role in the ischemia and reperfusion process. In this study, we aimed to examine the effect of L-arginine, tadalafil, and their combination for prevention of the ischemia reperfusion injury after testis torsion in rats. Methods: A total of 40 adult, male Sprague-Dawley rats were allocated into five groups. Three hours of left testicular torsion was performed in each group, excluding the control group. While the ischemia reperfusion (I/R) group had no treatment, I/R + Arg group received L-arginine, I/R + Td group received tadalafil and I/R + Arg + Td group received tadalafil and L-arginine 30 minutes before the detorsion. Then the left testis was untwisted for four hours of reperfusion. After bilateral orchiectomy, lipid peroxidation (LPx) and glutathione (GSH) activities were examined in testicular tissue. Spermatogenesis was evaluated with Johnsen's score. Results: LPx levels of the I/R group were found to be significantly higher than for groups that received drugs for both testes (p<0.001). GSH levels of the combination group were higher than I/R group in ipsilateral testis (p<0.01) and it was significantly higher than other groups for contralateral testis (p<0.001 for I/R group, p<0.01 for I/R + Arg, p<0.05 for I/R + Td). Mean Johnsen's score of the I/R group was found to be significantly lower than treatment groups in ipsilateral testis (p<0.001 for I/R + Arg + Td group, p<0.01 for other treatment goups) and contralateral testis (p<0.001). The mean Johnsen score of the combination group was significantly higher than that of other treatment groups in ipsilateral testis (p<0.05) and it was significantly higher than in the I/R + Td group in the contralateral testis (p<0.05). Conclusions: L-arginine, tadalafil, and combination of these two molecules showed protective effect against ischemia/reperfusion injury for both testes after unilateral testis torsion.

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Section: Introductionmentioning

confidence: 99%

The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury

Ozmerdiven

Çoşkun

Kaygısız

et al. 2017

CUAJ

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“…The fundamental approach for treating testicular torsion, which is accepted as an emergency pathology, is manual or surgical detorsion of the testes. [3] However, depending on the duration of the torsion, permanent testicular damage can ocCite this article as: Fırat F, Erdemir F, Kölükçü E, Gevrek F, Benli İ, Ünsal V. Oxytocin for preventing injury due to testicular torsion/detorsion in rats. Ulus Travma Acil Cerrahi Derg 2018; 24:89-96 ful conditions cannot be eliminated by antioxidants in the human body.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Fırat¹,

Erdemır²,

Kölükçü³

et al. 2017

Ulus Travma Acil Cerrahi Derg

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“…Testicular damage is directly correlated with the degree and duration of testicular torsion. However, correction of torsion and restoration of normal blood flow may sometimes fail to avoid the development of permanent spermatogenic failure and infertility (1). Ischemia/reperfusion (I/R) injury due to testicular torsion and detorsion causes some biochemical and morphological changes in the testicular tissue (2).…”

Section: Introductionmentioning

confidence: 99%

Effects of ozone therapy and taurine on ischemia/reperfusion-induced testicular injury in a rat testicular torsion model

Aydos¹,

Başar²,

Kul³

et al. 2014

Turk J Med Sci

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Background/aim: To investigate the effect of ozone and/or taurine treatment comparatively on testicular damage due to ischemia/ reperfusion (I/R) injury in an experimental torsion model in rats.Materials and methods: Adult Wistar rats with and without torsion/detorsion were used. In order to monitor the effect of ozone and/ or taurine treatment on testicular damage due to I/R injury, following histopathological investigation apoptotic indexes were scored by TUNEL method. Moreover, tumor necrosis factor receptor 1 (TNFR1), caspase 3, caspase 8, endothelial nitric oxide synthase (eNOS), tumor necrosis factor alpha (TNFα), and cytochrome C immunostainings were performed and the levels of malondialdehyde, glutathione peroxidase, superoxide dismutase, catalase, total sulfhydryl, and nitric oxide were determined in the testicular tissue.Results: Intraperitoneal ozone and/or taurine treatment prevented both histopathological damage and increase in the apoptotic index. Torsion did not exert an effect on the levels of TNFα and cytochrome C. Ozone and/or taurine treatment prevented increases in TNFR1, caspase 3, and caspase 8. The level of oxidative stress markers was unchanged. The increases in NO level and eNOS expression were prevented by ozone and/or taurine treatment in I/R groups. Conclusion:Using ozone therapy and/or taurine before reperfusion may be a solution for germ cell degeneration resulting from testicular torsion and related infertility.

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Testicular function after torsion of the spermatic cord

Cited by 253 publications

References 31 publications

The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury

The protective effect of L-arginine, tadalafil, and their combination in rat testes after ischemia and reperfusion injury

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Effects of ozone therapy and taurine on ischemia/reperfusion-induced testicular injury in a rat testicular torsion model

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