Testicular function and sexuality in adult patients with anorectal malformation

Trovalusci, Emanuele; Rossato, Marco; Gamba, Piergiorgio; Midrio, Paola

doi:10.1016/j.jpedsurg.2019.12.028

Cited by 14 publications

(11 citation statements)

References 29 publications

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“…Recently, many researches have revealed that the decline of male reproductive health and fertility was related to toxic substances found in the environment, particularly endocrine-disrupting chemicals such as phthalates ( Foster et al, 1980 ; Hu et al, 2020 ; Rodriguez-Sosa et al, 2020 ; Trovalusci et al, 2020 ). In addition, dibutyl phthalate (DBP) was also used in building materials, food packaging products, children’s products, and medical equipment all over the world, and it was ubiquitous in nature ( Guerra et al, 2010 ; Man et al, 2010 ; Jiang et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Exposure to Dibutyl Phthalate and Reproductive-Related Outcomes in Animal Models: Evidence From Rodents Study

Wang

Zhang

et al. 2021

Front. Physiol.

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Background: Dibutyl phthalate (DBP) was an endocrine disruptor, which may lead to cancer and affects reproductive function when accumulated in the body. But the precise role of DBP in the reproductive system remained controversial.Objective: We employed the meta-analysis to explore the relationship between DBP and reproductive-related outcomes.Methods: We searched relevant literature in PubMed, EMBASE, and Web of Science databases. The standardized mean differences (SMDs) and their 95% CIs were measured by random-effects models. Funnel plots and Egger’s regression test were applied to assess publication bias.Results: Finally, 19 literatures were included in this research. The outcomes revealed that DBP was negatively correlated with reproductive organs weight (testis weight: SMD: −0.59; 95% Cl: −1.23, −0.23; seminal vesicles weight: SMD: −0.74; 95% Cl: −1.21, −0.27; prostate weight: SMD: −0.46; 95% Cl: −0.76, −0.16) and sperm parameters (sperm morphology: SMD: 1.29; 95% Cl: 0.63, 1.94; sperm count: SMD: −1.81; 95% Cl: −2.39, −1.23; sperm motility: SMD: −1.92; 95% Cl: −2.62, −1.23).Conclusion: Our research demonstrated that DBP may be negatively associated with reproductive-related indicators, especially at Gestation exposure period and middle dose (100–500 mg/kg/day).

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Section: Introductionmentioning

confidence: 99%

Exposure to Dibutyl Phthalate and Reproductive-Related Outcomes in Animal Models: Evidence From Rodents Study

Wang

Zhang

et al. 2021

Front. Physiol.

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“…26 Trovalusci et al found an incidence of 33% of UDT in a series of 30 adult patients and half of these had bilateral UDT. 27 The mean testicular volume of these adult ARM patients was also significantly lower than controls. The AUA recommends orchiopexy between 6 to 18 months of age to try and preserve testicular function and reduce risk of testicular malignancy.…”

Section: Testicular Problemsmentioning

confidence: 74%

Long-term urologic and gynecologic follow-up and the importance of collaboration for patients with anorectal malformations

Skerritt

DaJusta

Fuchs

et al. 2020

Seminars in Pediatric Surgery

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“…Second, the remaining 54 articles were read in detail and the predetermined inclusion and exclusion criteria were applied. This process resulted in 17 studies eligible for qualitative synthesis [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] . Reference lists for the 17 papers included were screened (snowballing) without identifying additional eligible studies.…”

Section: Evidence Synthesismentioning

confidence: 99%

“…Kyrklund et al [22] reported ED prevalence of 5.6% among patients with low/intermediate ARM severity. Four studies used the International Index of Erectile Function (IIEF) questionnaire, and one of these used the short-form IIEF-5 instrument [17] , [18] , [20] , [23] , [35] . In three studies, ED was defined as an IIEF score of <26, and this applied for any level of dysfunction [17] , [18] , [20] .…”

Section: Evidence Synthesismentioning

confidence: 99%

“…Four studies used the International Index of Erectile Function (IIEF) questionnaire, and one of these used the short-form IIEF-5 instrument [17] , [18] , [20] , [23] , [35] . In three studies, ED was defined as an IIEF score of <26, and this applied for any level of dysfunction [17] , [18] , [20] . van den Hondel et al [23] only reported the prevalence of moderate to severe ED (27.3%).…”

Section: Evidence Synthesismentioning

confidence: 99%

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Long-term Functional Urinary and Sexual Outcomes in Patients with Anorectal Malformations—A Systematic Review

Bjoersum-Meyer

Kaalby

Lund

et al. 2021

European Urology Open Science

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Context Long-term urinary and sexual outcomes after repair of anorectal malformations (ARMs) are currently affected by concomitant malformations of the urinary tract and genitalia, sacral anomalies, and the surgical approach. However, the overall prevalence of urinary and sexual dysfunction remains unclear. Objective To evaluate the prevalence of urinary and sexual dysfunction in patients aged >10 yr after repair of ARM in infancy. Evidence acquisition A systematic literature review was performed using the Medline, Embase, and Cochrane databases. Selected studies were reviewed according to the Consolidated Standards of Reporting Trials (CONSORT) and Standards for the Reporting of Diagnostic Accuracy Studies (STARD) criteria. We included studies reporting the prevalence of the following outcomes: urinary incontinence (UI), lower urinary tract symptoms (LUTS), neurogenic bladder dysfunction (NBD), sexual dysfunction (SD), erectile dysfunction (ED), ejaculatory dysfunction, and birth rate. We initially identified 588 studies, of which 17 were included for evidence synthesis. Evidence synthesis A probabilistic meta-analysis on each subgroup revealed the following combined prevalence estimates: UI 16% (95% confidence interval [CI] 7–27%), LUTS/NBD 36% (95% CI 13–62%), SD among women 50% (95% CI 34–66%), ED 12% (95% CI 7–18%), ejaculatory dysfunction 16% (95% CI 9–25%), and birth rate 20% (95% CI 7–38%). Subgroup analysis showed a higher prevalence of ED and ejaculatory dysfunction among patients with high ARM severity when compared to low ARM severity. Conclusions Among patients undergoing ARM repair, we found a high prevalence of long-term impairment of UI, ED, and SD. We stress the need for larger multicentre trials with more comparable populations to optimise treatment and follow-up regimens. Patient summary We reviewed long-term outcomes for patients with anorectal malformations who underwent surgery and found that both urinary incontinence and sexual dysfunctions are common for both males and females.

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Testicular function and sexuality in adult patients with anorectal malformation

Cited by 14 publications

References 29 publications

Exposure to Dibutyl Phthalate and Reproductive-Related Outcomes in Animal Models: Evidence From Rodents Study

Exposure to Dibutyl Phthalate and Reproductive-Related Outcomes in Animal Models: Evidence From Rodents Study

Long-term urologic and gynecologic follow-up and the importance of collaboration for patients with anorectal malformations

Long-term Functional Urinary and Sexual Outcomes in Patients with Anorectal Malformations—A Systematic Review

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