Testicular hypoplasia in monochorionic dizygous twin with confined blood chimerism

Choi, Dong Hee; Kwon, Hwang; Lee, Soong Deok; Moon, Miri; Yoo, Eun-Gyong; Lee, Kyu Hyoung; Hong, Young Kwon; Kim, Gwangil

doi:10.1007/s10815-013-0109-8

Cited by 13 publications

(8 citation statements)

References 15 publications

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“…The case described by Bogdanova et al (2010) could be the first published case of possible freemartinism in human. Also the case of testicular hypoplasia (Choi et al, 2013) is comparable with reports of testicular hypoplasia in bulls with confined blood chimerism (Bongso et al, 1981). This means that close observation of genital anomalies is recommended in chimeric twins.…”

Section: Clinical Consequencessupporting

confidence: 87%

“…• Ambiguous external genitalia female (Williams et al 2004) • Absence of uterus/fallopian tubes (Bogdanova et al 2010) • Testicular hypoplasia (Choi et al 2013) • Glanular hypospadias (Rodriguez-Buritica et al 2015) blastocyst (as described before) where 'cells derived from one fetus could have migrated to the ectoderm of the other fetus' (p. e1100). It is possible this could result in chimerism in any organ, with still unknown consequences.…”

Section: Tablementioning

confidence: 99%

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Unusual Twinning Resulting in Chimerism: A Systematic Review on Monochorionic Dizygotic Twins

et al. 2017

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Traditionally, it is understood that dizygotic (DZ) twins always have a dichorionic placenta. However, with 8% blood chimerism in DZ twins, placental sharing is probably more common than previously has been recognized. In this article, we will review all available cases of monochorionic dizygotic (MCDZ) twins. A total of 31 twins have been described in literature. A monochorionic diamniotic placenta is reported in all cases. Assisted reproductive technology is responsible for the origin of the pregnancy in 82.1% of the cases. In 15.4% of the sex-discordant twins, a genital anomaly was reported in one of the twins. Chimerism is demonstrable in 90.3% of the twins, leading to various diagnostic difficulties. As this review shows that most MCDZ twins are discovered by accident, it can be argued that it is far more common than has been assumed until now. However, the prevalence is still unclear. Awareness of MCDZ twinning is important, with subsequently correct medical strategies. Similarly, the resulting (blood) chimerism is essential to consider in diagnostic procedures, pre- and postnatally. More research on the effect of placental transfusion between sex-discordant twins is required.

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Section: Clinical Consequencessupporting

confidence: 87%

Section: Tablementioning

confidence: 99%

Unusual Twinning Resulting in Chimerism: A Systematic Review on Monochorionic Dizygotic Twins

et al. 2017

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“…Therefore, we must provide accurate genetic counseling. It is also reported that genital anomalies occur in 15.4% of MCDZ twins, including ambiguous external genitalia in females, absence of the uterus and fallopian tubes in females, and testicular hypoplasia in males …”

Section: Discussionmentioning

confidence: 98%

“…It is also reported that genital anomalies occur in 15.4% of MCDZ twins, including ambiguous external genitalia in females, 11 absence of the uterus and fallopian tubes in females, 12 and testicular hypoplasia in males. 13 It has been suggested that microchimerism plays a role in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus and Behçet's disease. 14,15 Although the mechanisms of autoimmune disease correlated with microchimerism are unknown, we must cautiously observe the clinical symptoms of autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Twin anemia‐polycythemia sequence with blood chimerism in monochorionic dizygotic opposite‐sex twins

Suzuki

Kagami

Mitani

et al. 2019

J of Obstet and Gynaecol

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We report a case of twin anemia‐polycythemia sequence with blood chimerism in monochorionic dizygotic twins born to a 30‐year‐old woman who conceived via ovulation induction. The neonates developed twin anemia‐polycythemia sequence; the female twin had anemia and the male had polycythemia. We detected blood chimerism using fluorescence in situ hybridization (FISH). Twin anemia‐polycythemia sequence carries not only perinatal risks, but also genetic and immunological implications due to blood chimerism. Although previous reports have described twin‐to‐twin transfusion syndrome in monochorionic dizygotic twins, we report the first case of twin anemia‐polycythemia sequence in monochorionic dizygotic twins.

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“…A case of testicular hypoplasia in a monochorionic DZ twin with blood chimerism was recently reported by South Korean researchers (Choi et al, 2013). The twins were born to a 31-year-old mother who succeeded in becoming pregnant via embryo transfer, following five unsuccessful cycles of timed intercourse and two intrauterine inseminations.…”

Section: Monochorionic Dizygotic Twin With Blood Chimerismmentioning

confidence: 95%

Twins Reunited: Scientific and Personal Perspectives/Twin Research Studies: Multiple Birth Effects on IQ and Body Size; Life Style, Muscles, and Metabolism; Monochorionic Dizygotic Twin with Blood Chimerism; Amniocentesis for Twins/Twins in the Media: Identical Doctors; Freedom Fighter for Twins; Twin Scholarships; Auguste and Jean-Felix Piccard; Twins Born Apart

Segal

Mulligan

2014

Twin Res Hum Genet

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A reunion of 38-year-old female monozygotic twins took place in Daegu, South Korea, on January 14, 2014. Scientific and personal perspectives on this extraordinary event are provided. A review of timely twin research follows, covering the effects of multiple births on IQ and body size, lifestyle and physical fitness associations, a rare case of a dizygotic twin with blood chimerism and definitional issues surrounding amniocentesis-related loss in multiple birth pregnancies. Interesting and informative mention of twins in the media includes twin doctors, a twin freedom fighter, the availability of college scholarships for twins, a new book about the Piccard family (two of whose members were twins), and co-twins born before and after the new year. A follow-up to a previous mention of identical twin biatheletes is also provided.

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Testicular hypoplasia in monochorionic dizygous twin with confined blood chimerism

Cited by 13 publications

References 15 publications

Unusual Twinning Resulting in Chimerism: A Systematic Review on Monochorionic Dizygotic Twins

Unusual Twinning Resulting in Chimerism: A Systematic Review on Monochorionic Dizygotic Twins

Twin anemia‐polycythemia sequence with blood chimerism in monochorionic dizygotic opposite‐sex twins

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