Testicular Plasmacytoma in a Patient with the Acquired Immunodeficiency Syndrome

Ramadan, Ali; Naab, Tammey; Frederick, Winston; Green, William

doi:10.1177/030089160008600610

Cited by 14 publications

(7 citation statements)

References 9 publications

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“…[1][2][3][4] The other subtypes that are frequently reported include follicular lymphoma, plasmacytoma and lymphoblastic and Burkitt's-like lymphoma. 1,[12][13][14][15][16][17][18][19] The typical presentation is a testicular mass of variable size that is usually unilateral. However, bilateral involvement can occur at presentation and has been reported in up to 18% of the cases.…”

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confidence: 99%

Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases

et al. 2006

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The most common type of primary testicular lymphoma is diffuse large B-cell type, which has the potential for aggressive clinical behavior. Diffuse large B-cell lymphoma can be further subclassified into two major prognostic categories: germinal center B-cell-like and nongerminal center B-cell-like. Such distinction is made possible using the immunohistochemical expression of CD10, Bcl-6 and MUM1. The aim of this study was to stratify primary testicular lymphoma of the diffuse large B-cell type according to this scheme. Immunohistochemical stains for CD10, Bcl-6 and MUM1 were performed on 18 cases of primary testicular lymphoma of diffuse large B-cell type. Subclassification was carried out as previously described where CD10 and/or Bcl-6 positivity and negativity for MUM1 were considered indicative of germinal center B-cell-like type and the opposite expression as nongerminal center B-cell-like type. The proliferative activity was determined using immunostaining with the Ki-67 antibody. Of 18 cases, 16 (89%) were found to belong to the nongerminal center B-cell-like type. Two cases (11%) were classified as germinal center B-cell-like type; one had a CD10-positive, Bcl-6-positive and MUM1-negative profile, and the other was CD10 negative, Bcl-6 positive and MUM1 negative. The former occurred in a 38-year-old patient who was human immunodeficiency virus positive. All the cases expressed high proliferative activity (Z50% Ki-67 labeling). We conclude that most (89%) primary testicular lymphomas of the diffuse large B-cell type belong to the nongerminal center B-cell-like subgroup and have high proliferative activity.

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confidence: 99%

Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases

et al. 2006

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“…To the best of our knowledge, no case has been reported in the literature to date. Among the reported case reports involving EMP and infection by HIV, the locations of the tumors include the gingiva, the larynx, the central nervous system and the testes (4)(5)(6)(7)(8)(9)(10).…”

Section: Discussionmentioning

confidence: 99%

“…It also has no typical presentation or features, with diagnosis predominantly dependent on pathological analysis. In a literature search performed by a professional librarian using MEDLINE and EMBASE, it was found that studies on such neoplasms in HIV-infected patients are extremely rare, with only eight cases reported to date (4)(5)(6)(7)(8)(9)(10). To the best of our knowledge, the present study describes the first case of a solitary adrenal EMP in a patient with HIV.…”

Section: Introductionmentioning

confidence: 99%

Retroperitoneal laparoscopic management of a solitary extramedullary plasmacytoma associated with human immunodeficiency virus infection: A case report

Cao

et al. 2015

Oncology Letters

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Abstract. Extramedullary plasmacytoma (EMP) is a rare malignant tumor that is characterized by a malignant plasma cell neoplasm. Such neoplasms in human immunodeficiency virus (HIV)-infected patients are extremely rare. To the best of our knowledge, the present study describes the first case of a solitary adrenal EMP in a patient with HIV. A 35-year-old male who had been diagnosed with HIV 3 months previously presented with a 2-week history of intermittent right flank pain. Abdominal computed tomography revealed a soft-tissue density mass in the right adrenal gland area. The patient subsequently underwent a retroperitoneal laparoscopic adrenalectomy. Post-operative pathological diagnosis revealed a solitary EMP. Although the patient refused to undergo post-operative radiotherapy and chemotherapy, no recurrence was detected after 2 years of follow-up. The present case illustrates the fact that this rare type of solitary EMP associated with acquired immune deficiency syndrome (AIDS) can occur in the adrenal glands, and that retroperitoneal laparoscopic resection of the tumor may be a good method to manage this condition. In addition, although rare, solitary EMP should be considered in the differential diagnosis of an adrenal mass in HIV-infected patients.

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“…HIV is associated with many neoplasias, of which several are AIDS defining (non-Hodgkin's lymphoma, Kaposi syndrome, cervical carcinoma) [5,10]. Plasmacell malignancies are becoming more frequently noted in patients with HIV infection, although they are not yet AIDS-defining diseases [1,[4][5][6][7][8][9][13][14][15][16][17][18][19][20][21][22][23][24]. Patients with HIV infections have a 12-fold increased risk for myeloma compared to the general population [17], and this risk would be higher if other plasma-cell dyscrasias including plasmacytomas were included.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with HIV infections have a 12-fold increased risk for myeloma compared to the general population [17], and this risk would be higher if other plasma-cell dyscrasias including plasmacytomas were included. This patient's clinical features and tumor pathology could be multiple, EBV-associated, pleomorphic extramedullary plasmacytomas [1][2][3]13,15,[25][26][27]. Because the patient showed no features of a systemic plasma-cell neoplasm (i.e., no bone marrow involvement was present and there was no identifiable serum or urine monoclonal immunoglobulin spike), multiple myeloma was excluded.…”

Section: Discussionmentioning

confidence: 99%

HIV and plasmablastic lymphoma manifesting in sinus, testicles, and bones: A further expansion of the disease spectrum

et al. 2004

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Patients with HIV infection are at increased risk for B-cell neoplasms and plasma cell dyscrasias. Both B cell and plasma cell tumors tend to be intermediate or high grade and are frequently associated with Epstein-Barr virus. Patients with HIV infection are also at higher risk of acquiring plasmablastic lymphoma. Until this time, only sinus, oral gastrointestinal, and lung manifestation have been noted. In this report we describe a 41-year-old male with HIV infection who developed multiple pleomorphic, extramedullary plasmablastic lymphomas associated with Epstein-Barr virus. We review the clinical and immunological features of his malignancy and thereby expand the spectrum of disease to include additional sites (bones, testicles) not previously reported. Am.

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Testicular Plasmacytoma in a Patient with the Acquired Immunodeficiency Syndrome

Cited by 14 publications

References 9 publications

Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases

Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases

Retroperitoneal laparoscopic management of a solitary extramedullary plasmacytoma associated with human immunodeficiency virus infection: A case report

HIV and plasmablastic lymphoma manifesting in sinus, testicles, and bones: A further expansion of the disease spectrum

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