Testicular Sex Cord–Stromal Tumours: The Edinburgh Experience 1988–2002, and a Review of the Literature

Conkey, D.; Howard, G.C.W.; Grigor, Ken; McLaren, Duncan B.; Kerr, G.R.

doi:10.1016/j.clon.2005.04.009

Cited by 55 publications

(44 citation statements)

References 34 publications

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“…5,8,9 Among testicular neoplasms, it has been reported that Leydig cell tumors frequently present with gynecomastia, with the incidence reported as 15%-30%. 8,10 Testicular germ cell tumors, including seminoma and teratoma, can also present with gynecomastia, particularly in cases of tumors secreting β-HCG, which stimulates estrogen synthesis in normal Leydig cells. 5,11,12 Thus, the possibility of a testicular tumor should be considered in all male patients presenting with gynecomastia.…”

Section: Discussionmentioning

confidence: 99%

Testicular seminoma presenting with mediastinal lymphadenopathy and gynecomastia

et al. 2007

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Chest computed tomography (CT) of a 22-year-old man with a history of long-term low fever and nonproductive cough demonstrated lymphadenopathy in the superior, middle, and posterior mediastinum. Slight bilateral gynecomastia was also observed on the CT scan. Subsequent physical examination and ultrasonography revealed a left testicular mass, and abdominal CT showed retroperitoneal lymphadenopathy. Left orchiectomy was performed, with the histological examination confirming the diagnosis of seminoma.

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Section: Discussionmentioning

confidence: 99%

Testicular seminoma presenting with mediastinal lymphadenopathy and gynecomastia

et al. 2007

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“…29 Neoplasms from either Leydig or Sertoli cells of the testicular interstitium account for 10-30% of malignant tumors in pediatric patients. [29][30][31] Leukemia or lymphoma account for less than 10% of testicular masses; such masses can be bilaterally distributed. 32 Primary leukemia of the testis is rare.…”

Section: 28mentioning

confidence: 99%

Scrotal sonography revisited

Çarkaci

Ozkan

Lane

et al. 2009

J of Clinical Ultrasound

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Sonography is the imaging modality of choice for the scrotum because it is simple, relatively inexpensive, and quick. Recent technological advances and transducer improvements have led to exquisite high-resolution detail in gray-scale as well as Doppler imaging. The purposes of this pictorial essay are to review the anatomy and embryology of the scrotal contents and to review the various scrotal and extrascrotal pathologic conditions, including acute scrotum, pediatric and adult testicular and extratesticular scrotal neoplasms, traumatic lesions, and miscellaneous other scrotal lesions.

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“…The cytomorphology of the tumour cells of the large-cell calcifying SCT, for example, displays greater similarity to the Leydig than to the Sertoli cells. SCT also do not have a specific immunostaining profile: they react mostly positive with vimentin antibodies (90%), followed by cytokeratin (80%) and to a variable extent with inhibin (30-90%), calretinin (33%) and S100 (30-60%) [2,3,12,17,20]. The tumour cells are invariably negative for placental alkaline phosphatase (PLAP), alpha-fetoprotein and human chorion gonadotropin.…”

Section: Introductionmentioning

confidence: 96%

Molecular-cytogenetic characterisation of sex cord-stromal tumours: CGH analysis in sertoli cell tumours of the testis

et al. 2007

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Sertoli cell tumours (SCT) are rare and poorly explored neoplasias, and the genetic features of these uncommon tumours are largely unknown. Data about chromosomal aberrations in human SCT of the testis are very rare. We present in this paper the first molecular-cytogenetic study of SCT of the testis. DNA was isolated from paraffin-embedded tumour material from 11 patients with unilateral SCT. We used comparative genomic hybridisation to investigate changes in DNA copy number. The detected DNA imbalances showed variation from case to case, indicating a high genetic heterogeneity. Chromosomal aberrations were detected in 9 of the 11 tumours evaluated, with 13 losses versus 14 gains. The most frequent aberrations detected were gain of chromosome X (5 of 11 cases) followed by losses of entire or part of chromosomes 2 and 19 in three cases. This study suggests a high variability in histomorphological and genetic patterns. Only gain of the entire chromosome X seems to be a frequent aberration in these tumours. Further studies of these tumour types are necessary to clarify the significance of chromosomal alterations in carcinogenesis of SCT.

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Testicular Sex Cord–Stromal Tumours: The Edinburgh Experience 1988–2002, and a Review of the Literature

Cited by 55 publications

References 34 publications

Testicular seminoma presenting with mediastinal lymphadenopathy and gynecomastia

Testicular seminoma presenting with mediastinal lymphadenopathy and gynecomastia

Scrotal sonography revisited

Molecular-cytogenetic characterisation of sex cord-stromal tumours: CGH analysis in sertoli cell tumours of the testis

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