Testicular toxicity of cyanobacterial biomass in Japanese quails

Damková, Veronika; Pašková, Veronika; Banďouchová, Hana; Hilscherová, Klára; Sedláčková, Jana; Novotný, Ladislav; Pecková, Lucie; Vitula, F.; Pohanka, Miroslav; Pikula, Jiří

doi:10.1016/j.hal.2011.04.013

Cited by 14 publications

(10 citation statements)

References 38 publications

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“…There is a diversity of environmental pollutants that can impair avian reproduction either through the action on adult birds and developing embryos and foetuses, or both [61-63]. Lead, affecting multiple physiological functions in birds [39], belongs to such toxins.…”

Section: Discussionmentioning

confidence: 99%

Lead toxicosis of captive vultures: case description and responses to chelation therapy

Pikula

Hájková²,

Banďouchová

et al. 2013

BMC Vet Res

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BackgroundLead, a serious threat for raptors, can hamper the success of their conservation. This study reports on experience with accidental lead intoxication and responses to chelation therapy in captive Cinereous (Aegypius monachus) and Egyptian (Neophron percnopterus) Vultures.ResultsSoil contamination by lead-based paint sanded off the steel aviary resulted in poisoning of eight Cinereous and two Egyptian Vultures. A male Egyptian Vulture developed signs of apathy, polydipsia, polyuria, regurgitation, and stupor, and died on the next day. Liver, kidney and blood lead concentrations were 12.2, 8.16 and 2.66 μg/g, respectively. Laboratory analyses confirmed severe liver and kidney damage and anaemia. Blood Pb levels of Pb-exposed Cinereous Vultures were 1.571 ± 0.510 μg/g shortly after intoxication, decreased to 0.530 ± 0.165 μg/g without any therapy in a month and to 0.254 ± 0.097 μg/g one month after CaNa2EDTA administration. Eight months later, blood lead levels decreased to close to the background of the control group. Blood parameters of healthy Pb-non-exposed Cinereous Vultures were compared with those of the exposed group prior to and after chelation therapy. Iron levels in the lead-exposed pre-treatment birds significantly decreased after chelation. Haematocrit levels in Pb-exposed birds were significantly lower than those of the controls and improved one month after chelation. Creatine kinase was higher in pre-treatment birds than in the controls but normalised after therapy. Alkaline phosphatase increased after chelation. A marked increase in the level of lipid peroxidation measured as thiobarbituric acid reactive species was demonstrated in birds both prior to and after chelation. The ferric reducing antioxidant power was significantly lower in pre-treatment vultures and returned to normal following chelation therapy. Blood metallothionein levels in lead-exposed birds were higher than in controls. Reduced glutathione dropped after CaNa2EDTA therapy, while oxidised glutathione was significantly lower in both pre- and post-treatment birds. A chick in an egg produced by a Cinereous Vulture female two months after lead toxicosis died on day 40 of artificial incubation. Lead concentrations in foetal tissues were consistent with levels causing avian mortality.ConclusionsThe reported blood parameters and reproduction impairment in captive birds may have implications for professionals dealing with lead exposure in wild birds.

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Section: Discussionmentioning

confidence: 99%

Lead toxicosis of captive vultures: case description and responses to chelation therapy

Pikula

Hájková²,

Banďouchová

et al. 2013

BMC Vet Res

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“…However, the lower weight was not reflected in their biological quality because reproductive parameters such as egg viability, hatchability, and the overall effect of hatching in cyanobacterial biomass-exposed birds were better than in the control group. Males exposed to cyanobacteria in the feed showed moderate to marked atrophy of the seminiferous tubular epithelium with only sparse numbers of the developmental stages of spermatozoa and Sertoli cells [90]. Biomass-exposed birds had elevated CAT activities but decreased GPX activities and surprisingly lower levels of lipid peroxides (LPO) in the testis.…”

Section: Reproductive Toxicity Of Mcs On Birdsmentioning

confidence: 99%

“…The cell defensive system protecting testicular tissue from damage seemed to be insufficient and partly depleted after the chronic exposure of birds to the biomass. It might be hypothesized that compounds of hormonal activity, or some biologically active compounds potentially stimulating reproduction could be present in the complex cyanobacterial biomass [89,90]. The underlying mechanisms need further research.…”

Section: Reproductive Toxicity Of Mcs On Birdsmentioning

confidence: 99%

“…Consequently, cyanobacteria could potentially contribute to a hazardous effect on mammalian health via producing some endocrine disruptors with oestrogenic activity. Damkova et al [89,90] also hypothesized that apart from MCs, compounds of hormonal activity, or some biologically active compounds potentially stimulating reproduction could be present in the complex cyanobacterial biomass. Quantification of the total toxicity caused by MC variants and other secondary metabolites is a major scientific challenge that needs to be addressed in future toxicity studies dealing with harmful algal blooms (HABs) [153].…”

Section: Microcystin Variants Cyanobacterial Crude Extracts and Cyamentioning

confidence: 99%

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A review of reproductive toxicity of microcystins

Chen

Zhang

et al. 2016

Journal of Hazardous Materials

310

126

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“…On the other hand, the low hatching rates and the increased numbers of unfertilised eggs could also potentially be attributed to microcystininduced infertility in male Nile crocodiles. Daily exposure of male Japanese quails for eight weeks to low concentrations of MC-LR, MC-RR and MC-YR in their feed caused testicular atrophy and sparse spermatozoa (Damkova et al, 2011).…”

Section: Discussionmentioning

confidence: 97%

Vertical transmission of microcystins to Nile crocodile ( Crocodylus niloticus ) eggs

Singo

Myburgh

Laver

et al. 2017

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Cyanobacteria or blue green algae are known for their extensive and highly visible blooms in eutrophic, stagnant freshwater bodies. Climate change and global warming have also contributed to a rise in toxic cyanobacterial blooms. One of the most important cyanobacteria is Microcystis aeruginosa, which can synthesize various microcystins that can affect the health of terrestrial and aquatic animals. Commercial Nile crocodile (Crocodylus niloticus) farming in South Africa is based on keeping breeders (adult males and females) in big dams on farms (captive-bred approach). Unfortunately, cyanobacterial blooms in the breeder dams are a concern to farm owners, managers and veterinarians. The main objectives of this research project were to determine if microcystins were present in the contents of crocodile eggs and the liver and yolk of dead hatchlings, and to determine if the reduced hatchability on commercial farms might be caused by these toxins. Furthermore, the concentration of microcystins in the breeder dam was monitored on a monthly basis spanning the ovulation and egg laying period. During the hatching season microcystin concentrations in unfertilised eggs, egg shell membranes and in the yolk and liver of dead hatchlings were determined using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Microcystins were detected in Nile crocodile egg and hatchling samples. Microcystin (MC-LR, MC-RR, MC-YR) concentrations in the crocodile egg and hatchling samples collected from clutches with a good hatching rate (≥90%) ranged between 0 and 1.76 ng g, with the highest concentration in the egg shell membranes. Microcystin concentrations in samples collected from clutches with a bad hatching rate (≤10%) ranged from 0 - 1.63 ng g with the highest concentration detected in the hatchling yolk. However, the concentrations were probably underestimated as the percentage recovery from spiked samples was very low with the extraction method employed. Bayesian analysis suggests that the liver, yolk and unfertilised egg all have similar microcystin concentrations, while the membranes have (with moderate to high certainty) higher microcystin concentrations. There appears to be no difference in microcystin concentrations among good and bad clutches across all tissue types or within a specific tissue type, but due to the small sample size, it was not possible to determine whether microcystin affected the hatchability of Nile crocodile eggs. However, vertical transmission of microcystin variants to the Nile crocodile egg does occur and the possible implications for the survival of wild Nile crocodile populations should be ascertained.

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Testicular toxicity of cyanobacterial biomass in Japanese quails

Cited by 14 publications

References 38 publications

Lead toxicosis of captive vultures: case description and responses to chelation therapy

Lead toxicosis of captive vultures: case description and responses to chelation therapy

A review of reproductive toxicity of microcystins

Vertical transmission of microcystins to Nile crocodile ( Crocodylus niloticus ) eggs

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