Testicular Tumor and the
Acquired Immunodeficiency
Syndrome

Buzelin, F; Karam, George A.; Moreau, A; Wetzel, Oliver; Gaillard, Fanny

doi:10.1159/000475346

Cited by 26 publications

(11 citation statements)

References 11 publications

(17 reference statements)

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“…The mean age of patients with primary testicular lymphomas has shifted in recent years to a younger age group, a recent observation that is noted in multiple countries. 8,9 In our study, the median age was 60 years. In three previous studies, the median ages were reported as 67, 69 and 66 years, respectively.…”

Section: Discussionmentioning

confidence: 75%

“…[5][6][7] In HIVpositive patients, the incidence of primary testicular lymphoma is increased, and it usually occurs at a younger age and sometimes is the initial manifestation of the disease, facts that may partially account for the changing demographics. 8,9 It is believed that the overall incidence and mortality from primary testicular lymphomas is on the increase, a trend that has been found not only in North America but also in the United Kingdom, Italy and the Netherlands. [5][6][7][8][9][10][11] Although they encompass a heterogeneous group of lymphomas, the most common primary testicular lymphoma is diffuse large B-cell lymphoma, which comprises more than 70% of the cases in most reported series.…”

mentioning

confidence: 99%

“…8,9 It is believed that the overall incidence and mortality from primary testicular lymphomas is on the increase, a trend that has been found not only in North America but also in the United Kingdom, Italy and the Netherlands. [5][6][7][8][9][10][11] Although they encompass a heterogeneous group of lymphomas, the most common primary testicular lymphoma is diffuse large B-cell lymphoma, which comprises more than 70% of the cases in most reported series. [1][2][3][4] The other subtypes that are frequently reported include follicular lymphoma, plasmacytoma and lymphoblastic and Burkitt's-like lymphoma.…”

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confidence: 99%

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Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases

et al. 2006

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The most common type of primary testicular lymphoma is diffuse large B-cell type, which has the potential for aggressive clinical behavior. Diffuse large B-cell lymphoma can be further subclassified into two major prognostic categories: germinal center B-cell-like and nongerminal center B-cell-like. Such distinction is made possible using the immunohistochemical expression of CD10, Bcl-6 and MUM1. The aim of this study was to stratify primary testicular lymphoma of the diffuse large B-cell type according to this scheme. Immunohistochemical stains for CD10, Bcl-6 and MUM1 were performed on 18 cases of primary testicular lymphoma of diffuse large B-cell type. Subclassification was carried out as previously described where CD10 and/or Bcl-6 positivity and negativity for MUM1 were considered indicative of germinal center B-cell-like type and the opposite expression as nongerminal center B-cell-like type. The proliferative activity was determined using immunostaining with the Ki-67 antibody. Of 18 cases, 16 (89%) were found to belong to the nongerminal center B-cell-like type. Two cases (11%) were classified as germinal center B-cell-like type; one had a CD10-positive, Bcl-6-positive and MUM1-negative profile, and the other was CD10 negative, Bcl-6 positive and MUM1 negative. The former occurred in a 38-year-old patient who was human immunodeficiency virus positive. All the cases expressed high proliferative activity (Z50% Ki-67 labeling). We conclude that most (89%) primary testicular lymphomas of the diffuse large B-cell type belong to the nongerminal center B-cell-like subgroup and have high proliferative activity.

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Section: Discussionmentioning

confidence: 75%

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confidence: 99%

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confidence: 99%

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Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases

et al. 2006

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“…In contrast to earlier reports this investigation discovered that the median age of patients at admission is changing to younger men (2). Additionally, previous published patient cohorts consist of patients with acquired immune defect (17,18). In our cases no HIVinfection could be detected.…”

Section: Discussionmentioning

confidence: 76%

Primary testicular lymphoma: A strictly homogeneous hematological disease?

Kemmerling

Stintzing²,

Mühlmann³

et al. 2010

Oncol Rep

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Abstract. Primary testicular lymphomas display mostly aggressive diffuse large cell B-cell lymphomas, which could be further subclassified into germinal center B-cell-like and an activated B-cell phenotype via immunohistochemistry. A retrospective analysis of primary testicular lymphomas diagnosed at the Institute of Pathology, Salzburger Landeskliniken (SALK) between January 1997 and December 2008 was done. Immunohistochemical staining and complete clinical data evaluation was carried out and linked to overall survival time. We found 18 cases of primary testicular lymphoma diagnosed in elderly patients showing no side predilection and having an aggressive clinical behavior with short overall survival independent of treatment. The lymphomas could for the most be classified into diffuse large cell B-cell lymphomas [15/18 (83.3%)] showing a nonsignificant prevalence of activated B cell phenotype [9/15 (60%)] compared to the germinal centre phenotype [6/15 (40%)]. Two of the cases were mantle cell lymphomas consisting of the infrequent pleomorphic subtype. The survival analysis revealed no significant difference for any of the investigated antigens. Primary testicular lymphomas are for the most DLBCL, but subtype classification reveal molecular heterogeneity inside this lymphoma entity. A distinction between those subtypes is necessary because of different clinical behavior and treatment.

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“…These patients usually present with disease at an early age (median of 37 years); have aggressive histologies (immunoblastic or small-non cleaved cell subtype); and have a worse prognosis. 4,5,32 Primary Metastasis to unusual extranodal sites is quite common, and these metastases may be present at initial disease presentation or develop later in the disease course. These sites include the CNS, Waldeyer ring, skin, and lung.…”

Section: Discussionmentioning

confidence: 99%

Primary Testicular and Intraocular Lymphomas: Two Case Reports and a Review of the Literature

Wallace

Altemare

Shen

et al. 2006

Survey of Ophthalmology

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Testicular lymphoma is a rare neoplasm of the testis that is most commonly seen in older patients. It metastasizes preferentially to extranodal sites, including the skin, central nervous system, Waldeyer ring, contralateral testis, and lung. Two case reports of patients with a history of testicular lymphoma who developed involvement of the vitreous and retina are presented. These are interesting cases as the testis, central nervous system, and eye are all immune privileged organs, which may account for occurrence of disease in these sites. Histopathologic examination of diagnostic vitrectomy specimens from both cases showed atypical lymphoid cells with immunoglobulin heavy chain (IgH) gene rearrangements, consistent with the diagnosis of intraocular B-cell lymphoma. The results of a literature review of all reports of ocular involvement with testicular lymphoma are discussed. Patients with testicular lymphoma are at risk for relapse, particularly in the central nervous system. Clinicians should be suspicious for intraocular lymphoma in patients with a history of testicular lymphoma who present with vitritis or retinal lesions.

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Testicular Tumor and the Acquired Immunodeficiency Syndrome

Cited by 26 publications

References 11 publications

Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases

Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases

Primary testicular lymphoma: A strictly homogeneous hematological disease?

Primary Testicular and Intraocular Lymphomas: Two Case Reports and a Review of the Literature

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