As dermatology patients complain that their psychological distress is extensive and often overlooked, it is concerning that there is a paucity of research investigating factors associated with acne-related QOL. This study, therefore, aimed to compile a preliminary list of risk factors for psychosocial distress as a result of having acne in adulthood, while specifically examining the role of an under investigated variable -perceived stigma -due to the high levels of stigmatization reported by these individuals. Adults with acne (N=119, M/F: 38/81; mean age: M = 26.37, SD =7.97), recruited from private dermatology offices in Athens were administered the Feelings of Stigmatization Questionnaire (FSQ; Ginsburg & Link, 1989) and Acne-Specific Quality of Life Questionnaire (Acne-QoL; Botek, Girman, Light, Lookingbill, Martin, & Thiboutot, 2001). Multiple regression analyses were conducted in order to assess the capacity of various psychosocial and demographic variables to predict acne-related QOL. While participants' gender, age, history of acne and selfrated severity of acne emerged as significant predictors of acne-related QOL, perceived stigma made the largest contribution to the regression model. This research study provides preliminary evidence that adults who feel stigmatized are at risk for experiencing a poor quality of life as a result of having acne. Potential risk factors of secondary importance, which can aid the screening of psychological distress in these individuals, may also include one's self-rated severity of acne, age, gender and previous history of acne.