Testing a new mechanism for left interventricular septal pacing: the transseptal route A feasibility and safety study

Abstract

Left interventricular septal pacing is feasible. In our study it was safely performed in six goats. The pacing threshold was low, and the stability of the lead system was good. Implantations in humans and animals and haemodynamic evaluations are needed to reveal the potential benefits of this new form of left interventricular septal pacing.

The Deleterious Consequences of Right Ventricular Apical Pacing: Time to Seek Alternate Site Pacing

“…A transseptal approach to endocardial left ventricular pacing has also been suggested but it is technically difficult and there is need for permanent anticoagulation to avoid thromboembolism 71 . Experimentally, in animals, left ventricular septal pacing has been effected via a transvenous approach from the right side of the interventricular septum with the use of a special lead and guiding sheath 72 . Permanent His bundle pacing has also been suggested and animal data indicate that this may be feasible and it might be an option in the future 73–75 …”

Septal atrial pacing for the prevention of atrial fibrillation

“…Non-pharmacological therapies have been investigated, including surgery, internal defibrillators, catheter ablation, pacemakers, or the combination of catheter ablation with atrial pacing and ventricular pacing. [4][5][6][7][8] Recently, techniques of multisite atrial pacing have been introduced. For example, bi-atrial [9][10][11][12] and interatrial septal pacing 13 showed promising preliminary results in AF prevention.…”

Electrophysiological Insights into Three Modalities of Left Bundle Branch Area Pacing in Patients Indicated for Pacing Therapy

“…This then raises the question of whether the impact of DSP on clinical outcomes would be similar to LBBP. Left ventricular septal pacing (LVSP) by a transvenous approach through the interventricular septum (IVS) with favorable electrical and mechanical effects in animals was explored in the past 12,13) and in humans more recently. 14,15) However, definitive outcome studies remain warranted.…”