Testing active membranes for bone regeneration: A review

Toledano, Manuel; Manzano-Moreno, Francisco Javier; Ruíz, Concepción; Osorio, Raquel

doi:10.1016/j.jdent.2021.103580

Cited by 32 publications

(53 citation statements)

References 83 publications

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“…Surface nanoroughness (SRa) was examined, in Osorio et al, 2017 [ 18 ], Osorio et al, 2020 [ 29 ] and Toledano-Osorio et al, 2021 [ 25 ], using atomic force microscopy (AFM). A specific software (Nanoscope) was employed to measure fiber to fiber distance and fiber diameters with Image J .…”

Section: Resultsmentioning

confidence: 99%

“…There are multiple factors to be studied on the present membranes. Multi-parametric characterization comprises the study of surface characteristics such as porosity, pore size and roughness, mechanical properties of the surface, in vitro static bioactivity and biological characterization by cell culture methods are required [ 11 , 25 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…The loss of antimicrobial effect is explained by the full coverage of the NMs surface by non-vital bacterial cells [ 28 ]. In addition, it has been previously claimed the importance of modifying the membrane’s structure by adding metal components as zinc to achieve antibacterial effect [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…This feature poses a pivotal breakthrough in current tissue engineering. Adding some extra components allows the modification of the physical and biological properties to improve the interaction with the surrounding tissue [ 20 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Electrospun polymer-based membranes loaded with ZnO have shown enhanced cell proliferation/wound healing [ 4 ]. Incorporation of Zn into a membrane for GBR favors the proliferation of osteoblasts [ 25 ], triggers bone neoformation and inhibits bacterial biofilm formation [ 28 , 29 , 30 ]. In addition, animal studies using Zn-doped nanostructured membranes show faster bone healing and regeneration [ 9 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Toledano

Vallecillo-Rivas

Osório³

et al. 2021

Polymers

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Barrier membranes are employed in guided bone regeneration (GBR) to facilitate bone in-growth. A bioactive and biomimetic Zn-doped membrane with the ability to participate in bone healing and regeneration is necessary. The aim of the present study is to state the effect of doping the membranes for GBR with zinc compounds in the improvement of bone regeneration. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. A narrative exploratory review was undertaken, focusing on the antibacterial effects, physicochemical and biological properties of Zn-loaded membranes. Bioactivity, bone formation and cytotoxicity were analyzed. Microstructure and mechanical properties of these membranes were also determined. Zn-doped membranes have inhibited in vivo and in vitro bacterial colonization. Zn-alloy and Zn-doped membranes attained good biocompatibility and were found to be non-toxic to cells. The Zn-doped matrices showed feasible mechanical properties, such as flexibility, strength, complex modulus and tan delta. Zn incorporation in polymeric membranes provided the highest regenerative efficiency for bone healing in experimental animals, potentiating osteogenesis, angiogenesis, biological activity and a balanced remodeling. Zn-loaded membranes doped with SiO2 nanoparticles have performed as bioactive modulators provoking an M2 macrophage increase and are a potential biomaterial for promoting bone repair. Zn-doped membranes have promoted pro-healing phenotypes.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Toledano

Vallecillo-Rivas

Osório³

et al. 2021

Polymers

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Synthesis of composite corn starch/hydroxyapatite nanoparticle biomembranes and their effect on mineralization by osteoblasts

Silva,

de Melo,

Sponchiado

et al. 2023

J of Applied Polymer Sci

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Bone defects and injuries are challenging issues in regenerative medicine. Guided bone regeneration (GBR) techniques use biomaterials as scaffolds to support the healing of damaged bone tissue. In this context, there is growing interest in developing new biomaterials with bioabsorbable and bioactive properties to increase GBR effectiveness. In this study, composite corn starch/hydroxyapatite nanoparticle (HAp) biomembranes were synthesized to achieve bioresorbable and bioactive properties compatible with applications in GBR. Starch is a renewable source and presents suitable rheological properties for membrane preparation; in turn, HAp is well known for its osteogenic properties. The biomembranes were prepared by solvent casting (5 wt% aqueous corn starch suspension containing different amounts of HAp (i.e., 0, 2, 5, and 10% of the corn starch weight), to give the membranes HAp_0%, HAp_2%, HAp_5%, and HAp_10%, respectively). The physicochemical and biological properties of the biomembranes were assessed. The concentrations of up to 10% of HAp were homogeneously dispersed in the composite biomembranes. HAp addition increased the biodegradability and the ability of the biomembranes to release Ca2+. The biomembranes containing HAp were more mechanically resistant and less flexible and were not toxic to osteoblasts. Moreover, compared to pure corn starch biomembranes, osteoblasts adhered better to the composite biomembranes. The higher the HAp content, the greater the mineralization promoted by osteoblasts on the composite biomembranes. HAp addition also resulted in composite biomembranes with better fracture healing efficiency in vitro. Therefore, composite corn starch/HAp biomembranes have excellent characteristics, including biodegradability, bioactivity, mechanical strength, and biocompatibility, for the development of new materials aimed at GBR.

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Asymmetric resorbable‐based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

Bee

Hamid

2022

J Biomed Mater Res

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Guided tissue regeneration (GTR) and guided bone regeneration (GBR) are two common dental regenerative treatments targeted at reconstructing damaged periodontal tissue and bone caused by periodontitis. During GTR/GBR treatment, a barrier membrane is placed in the interface between the soft tissue and the periodontal defect to inhibit soft tissue ingrowth and creating a space for the infiltration of slowgrowing bone cells into the defect site. Recently, asymmetric resorbable-based barrier membrane has received a considerable attention as a new generation of GTR/GBR membrane. Despite numerous literatures about asymmetric-based membrane that had been published, there is lacks comprehensive review on asymmetric barrier membrane that particularly highlight the importance of membrane structure for periodontal regeneration. In this review, we systematically cover the latest development and advancement of various kinds of asymmetric barrier membranes used in periodontal GTR/GBR application. Herein, the ideal requirements for constructing a barrier membrane as well as the rationale behind the asymmetric design, are firstly presented. Various innovative methods used in fabricating asymmetric barrier membrane are being further discussed. Subsequently, the application and evaluation of various types of asymmetric barrier membrane used for GTR/GBR are compiled and extensively reviewed based on the recent literatures reported. Based on the existing gap in this field, the future research directions of asymmetric resorbable-based barrier membrane such as its combination potential with bone grafts, are also presented.

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Testing active membranes for bone regeneration: A review

Cited by 32 publications

References 83 publications

Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Zn-Containing Membranes for Guided Bone Regeneration in Dentistry

Synthesis of composite corn starch/hydroxyapatite nanoparticle biomembranes and their effect on mineralization by osteoblasts

Asymmetric resorbable‐based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

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