Testing sleepiness and vigilance in the sleep laboratory

Coelho, Fernando Morgadinho Santos; Narayansingh, Marc; Murray, Brian J.

doi:10.1097/mcp.0b013e32834b7e04

Cited by 22 publications

(11 citation statements)

References 46 publications

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“…The MWT has also been confirmed as an important test to quantify Excessive Daytime Sleepiness, as well as to provide an indicator of future risk of accidents [43, 54]. Patients with TBI are typically administered the Multiple Sleep Latency Test [55], however the MWT is more appropriate as excessive daytime sleepiness is the more common sleep concern for those with severe TBI [56]. Furthermore, excessive daytime sleepiness impairs function and puts patients at risk of sustaining further injury [54].…”

Section: Methodsmentioning

confidence: 99%

Evaluating the impact of treatment for sleep/wake disorders on recovery of cognition and communication in adults with chronic TBI

et al. 2013

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ObjectiveTo longitudinally examine objective and self-reported outcomes for recovery of cognition, communication, mood and participation in adults with traumatic brain injury (TBI) and co-morbid post-traumatic sleep/wake disorders.DesignProspective, longitudinal, single blind outcome study.SettingCommunity-based.ParticipantsTen adults with moderate–severe TBI and two adults with mild TBI and persistent symptoms aged 18–58 years. Six males and six females, who were 1–22 years post-injury and presented with self-reported sleep/wake disturbances with onset post-injury.InterventionsIndividualized treatments for sleep/wake disorders that included sleep hygiene recommendations, pharmacological interventions and/or treatments for sleep apnea with follow-up.Main outcome measuresInsomnia Severity Index, Beck Depression and Anxiety Inventories, Latrobe Communication Questionnaire, Speed and Capacity of Language Processing, Test of Everyday Attention, Repeatable Battery for the Assessment of Neuropsychological Status, Daily Cognitive-Communication and Sleep Profile.ResultsGroup analysis revealed positive trends in change for each measure and across sub-tests of all measures. Statistically significant changes were noted in insomnia severity, p = 0.0003; depression severity, p = 0.03; language, p = 0.01; speed of language processing, p = 0.007.ConclusionsThese results add to a small but growing body of evidence that sleep/wake disorders associated with TBI exacerbate trauma-related cognitive, communication and mood impairments. Treatment for sleep/wake disorders may optimize recovery and outcomes.

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Section: Methodsmentioning

confidence: 99%

Evaluating the impact of treatment for sleep/wake disorders on recovery of cognition and communication in adults with chronic TBI

et al. 2013

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“…DS is measured by electroencephalographic correlates of sleepiness and markers of sleep with objective tests, such as the Multiple Sleep Latency Test or the Maintenance of Wakefulness Test. However, the rather high costs of these diagnostic tools restrict their overall usefulness in clinical practice . Alternatives to the objective tests are self‐report questionnaires such as the Epworth Sleepiness Scale (ESS) .…”

Section: Theoretical Frameworkmentioning

confidence: 99%

Daytime sleepiness in renal transplant recipients is associated with immunosuppressive non‐adherence: a cross‐sectional, multi‐center study

Burkhalter

Wirz‐Justice

Cajochen

et al. 2013

Clinical Transplantation

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“…In a similar setting, the propensity for sleep can be measured but allowing the participant to lie down and sleep if possible. From this test, the amount of time it takes the participant to initiate sleep, measured as the latency to stage 1 non-rem sleep (N1), as well as the latencies to deeper stages of sleep and rapid eye movement (REM) sleep can be assessed (Littner et al, 2005; Coelho et al, 2011). As this test is usually done several times during the day is referred to as the multiple sleep latency test (MSLT).…”

Section: Introductionmentioning

confidence: 99%

The effects of theta-burst stimulation on sleep and vigilance in humans

Mensen

Gorban

Niklaus

et al. 2014

Front. Hum. Neurosci.

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Repetitive transcranial magnetic stimulation (TMS) has become a popular tool to modulate neuronal networks and associated brain functions in both clinical and basic research. Yet few studies have examined the potential effects of cortical stimulation on general levels of vigilance. In this exploratory study, we used theta-burst protocols, both continuous (cTBS) and intermittent (iTBS) patterns, to examine whether inhibition or excitation of the left dorso-lateral prefrontal cortex (dlPFC) was able to induce reliable and acute changes to vigilance measures, compared to the left dorso-lateral associative visual cortex (dlAVC) as a control site in line with previous work. Partially sleep restricted participants underwent four separate sessions in a single day, in a between subjects design for TBS stimulation type and within subjects for locaton, each consisting of maintenance of wakefulness test (MWT), a sleep latency test, and a psychomotor vigilance task (PVT). TBS significantly affected measures of sleep consolidation, namely latency to sleep stage 2 and sleep efficiency, but had no effects on sleep drive or psychomotor vigilance levels for either TBS type or location. Contrary to our initial hypothesis of the dlAVC as a control site, stimulation to this region resulted in the largest differential effects between stimulation types. Moreover, the effect of TBS was found to be consistent throughout the day. These data may provide the basis for further investigation into therapeutic applications of TBS in sleep disorders.

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Testing sleepiness and vigilance in the sleep laboratory

Abstract: Objective tests such as the MSLT and MWT are useful in the diagnosis and management of patients with EDS. However, the relatively high cost can restrict their overall usefulness in clinical medicine. Newer simple tests are under development.

Cited by 22 publications

References 46 publications

Evaluating the impact of treatment for sleep/wake disorders on recovery of cognition and communication in adults with chronic TBI

Evaluating the impact of treatment for sleep/wake disorders on recovery of cognition and communication in adults with chronic TBI

Daytime sleepiness in renal transplant recipients is associated with immunosuppressive non‐adherence: a cross‐sectional, multi‐center study

The effects of theta-burst stimulation on sleep and vigilance in humans

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