Testosterone and 17β-oestradiol secretion of the human ovary. II. Normal postmenopausal women, postmenopausal women with endometrial hyperplasia and postmenopausal women with adenocarcinoma of the endometrium

Botella-Llusiá, J; Oriol-Bosch, A.; Sánchez-Garrido, F; Tresguerres, J.A.F.

doi:10.1016/0378-5122(80)90054-7

Cited by 17 publications

(3 citation statements)

References 12 publications

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“…A number of explanatory factors need to be considered. Evidence from the studies of ovarian-peripheral venous blood gradients (Botella-Llusiá et al, 1979;Longcope et al, 1980;Lucisano et al, 1984;Nagamani et al, 1986) suggests that compensatory increases in androgens from the post-menopausal ovary may occur, at least in a substantial proportion of postmenopausal women. It has been postulated that this production may depend, in varying degrees, on gonadotrophic stimulation of interstitial cells of the post-menopausal ovary (Judd et al, 1974).…”

Section: Ovarian Androgen Production and Nutritional Factorsmentioning

confidence: 99%

“…Other studies, covering a wider age span, have suggested that adrenal androgen production declines with age, independently of the menopause (Crilly et al, 1979;Vermeulen, 1980). The picture is further complicated by a number or invasive studies, measuring the gradient in steroid hormones between ovarian and peripheral venous blood (Botella-Llusiá et al, 1979;Longcope et al, 1980;Lucisano et al, 1984;Nagamani et al, 1986), and suggesting considerable inter-individual variability in post-menopausal ovarian activity, with extreme levels of hormone production possibly being linked to endometrial disease.…”

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confidence: 99%

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Androgens and the menopause; a study of 40–60‐year‐old women

Bancroft¹,

Cawood²

1996

Clinical Endocrinology

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Section: Ovarian Androgen Production and Nutritional Factorsmentioning

confidence: 99%

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confidence: 99%

Androgens and the menopause; a study of 40–60‐year‐old women

Bancroft¹,

Cawood²

1996

Clinical Endocrinology

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“…If androstenedione is the most abundant circulating androgen, testosterone is a direct precursor for E 2 and might constitute a significant pool for its biosynthesis in postmenopausal women with endometrial cancer. In this regard, it was demonstrated that testosterone concentration in ovarian veins is higher in women with endometrial cancer than in diseasefree women (127,128). Moreover, ovaries with stromal hyperplasia have increased secretion of androgens, a pathology frequently observed in women with endometrial cancer (129).…”

Section: Aromatase In Normal Endometriummentioning

confidence: 95%

Recent advances on the action of estrogens and progestogens in normal and pathological human endometrium

Pasqualini¹,

Chétrite

2010

Hormone Molecular Biology and Clinical Investigation

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Hormonal control in the development of the normal endometrium is of the utmost importance. It is well established that the two main hormones involved in this process are estradiol and progesterone, which are also implicated in the pathological conditions concerning endometriosis and endometrial carcinoma. There are two types of endometrial carcinoma: type I which represents 80%-90% is hormone-dependent, whereas the remainder is type II and is hormone-independent. The endometrial tissue contains all the enzymatic systems in the formation and transformation of the various hormones, including aromatases, sulfatases, sulfotransferases, hydroxysteroid dehydrogenases, hydroxylases, and glucuronidases. It is interesting to note that increased sulfatase activity is correlated with severity of endometriosis. An increased sulfatase/sulfotransferase ratio represents a poor prognosis in patients with endometrial carcinoma. Treatment with hormone replacement therapy (estrogens+progestogens), as well as with tibolone, is most effective in protecting this tissue by climacteric alterations, owing to the significant decrease of ovarian hormones. In conclusion, enzymatic control can open appealing perspectives to protect this organ from possible pathological alterations.

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Is there an altered steroid profile in patients with endometrial carcinoma?

Möllerström

Carlström

Lagrelius

et al. 1993

Cancer

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Background. Besides the well‐known association between endometrial carcinoma (EC) and unopposed estrogen, androgens also may play a role in this respect; however, previous studies on endogenous estrogens and androgens in patients with EC and control subjects have yielded mostly divergent results, probably because of the use of poorly defined control groups. Methods. Circulating steroid and pituitary hormones and sex hormone–binding globulin were measured in patients with EC and matched control groups of either patients with nonmalignant postmenopausal bleeding (hospital control subjects) and healthy, symptom‐free women (nonhospital control subjects). Results. Patients with EC had higher serum levels of adrenal C21 and C19 steroids, estrogens, and biologically active testosterone than nonhospital control subjects, whereas the hospital control subjects constituted an intermediate group in this respect. Conclusions. The results clearly indicate an altered steroid homeostasis, probably reflecting an increased “adrenal drive” in patients with EC. The results also stress the necessity of using strictly defined, healthy, symptom‐free control subjects instead of the frequently used hospital control subjects when studying more subtile endocrine aberrations. Cancer 1993; 72:173–81.

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Testosterone and 17β-oestradiol secretion of the human ovary. II. Normal postmenopausal women, postmenopausal women with endometrial hyperplasia and postmenopausal women with adenocarcinoma of the endometrium

Cited by 17 publications

References 12 publications

Androgens and the menopause; a study of 40–60‐year‐old women

Androgens and the menopause; a study of 40–60‐year‐old women

Recent advances on the action of estrogens and progestogens in normal and pathological human endometrium

Is there an altered steroid profile in patients with endometrial carcinoma?

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