Testosterone for anemia in maintenance dialysis.

Mayer, Peter; Robinson, Brian H.

doi:10.1136/bmj.3.5770.373-b

Cited by 4 publications

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“…Based on the erythropoietic action of these hormones, several studies in the 1970s were designed to determine the effect of AND on the anemia of CRF (38)(39)(40)(41)(42)(43)(44)(45). These studies demonstrated that AND had a favorable effect on anemia in stable HD patients, some showing a dramatic response.…”

Section: Androgens and Renal Anemiamentioning

confidence: 99%

“…These studies demonstrated that AND had a favorable effect on anemia in stable HD patients, some showing a dramatic response. Nevertheless, the results varied greatly due to the heterogeneity of patients and the diversity of compounds used (40,41). Overall, before the advent of rHuEPO, AND were the mainstay of nontransfusional treatment for anemic patients on dialysis.…”

Section: Androgens and Renal Anemiamentioning

confidence: 99%

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Effect of Androgens on Anemia and Malnutrition in Renal Failure: Implications for Patients on Peritoneal Dialysis

Navarro

Mora

2001

Perit Dial Int

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Objective To analyze the implications of the potential use of androgens in peritoneal dialysis patients, focusing on their effects on hematologic and nutritional parameters. This manuscript reviews the different compounds for clinical use, dosage schedules, adverse effects, and how therapy with androgens might be used to treat anemia and malnutrition in these dialysis patients. Data Sources Studies in the literature dealing with the effects of androgens on hematologic and nutritional parameters, and their role in uremic anemia and malnutrition. Study Selection Studies in which uremic patients received androgens as therapy for anemia or malnutrition. Data Extraction Data were abstracted from all of these studies. Results This review shows that androgens are anabolic substances that also have significant actions on erythropoiesis. A number of clinical studies in uremic patients have found that these compounds have beneficial effects on hematologic parameters and nutritional status, similarly to other therapies, such as recombinant human erythropoietin and recombinant human growth hormone, respectively. Conclusions Androgens have been shown to have a beneficial effect on anemia due to renal disease and on nutritional status in uremic patients. Further studies need to be done with larger groups of patients. Objectives for additional research are suggested.

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Section: Androgens and Renal Anemiamentioning

confidence: 99%

Section: Androgens and Renal Anemiamentioning

confidence: 99%

Effect of Androgens on Anemia and Malnutrition in Renal Failure: Implications for Patients on Peritoneal Dialysis

Navarro

Mora

2001

Perit Dial Int

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Hematologic Problems of Dialysis Patients

Eschbach¹

1983

Replacement of Renal Function by Dialysis

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Navarro

Mora

2001

International Urology and Nephrology

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Androgens were the mainstay of treatment of renal anemia prior to the introduction of recombinant human erythropoietin. With the introduction of this recombinant hormone, the protocols of treatment of anemia were completely modified, and the use of androgens was relegated to the background. However, several authors have continued showing interest in the use of androgenic steroids for the treatment of anemia. This review examines several aspects of aging on androgenic hormones and hematopoiesis, the effects of androgen administration on hematological parameters, the side effects of these compounds and the future of this treatment for anemia in renal patients.

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Testosterone for anemia in maintenance dialysis.

Abstract: life of this important chemosterilizer, investigations should be undertaken with the polymeric,4 rather than the monomeric, form of glutaraldehyde.Full details of this work will be published elsewhere.-We are, etc.,

Cited by 4 publications

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Effect of Androgens on Anemia and Malnutrition in Renal Failure: Implications for Patients on Peritoneal Dialysis

Effect of Androgens on Anemia and Malnutrition in Renal Failure: Implications for Patients on Peritoneal Dialysis

Hematologic Problems of Dialysis Patients

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