Testosterone Levels Among Men with Spinal Cord Injury Admitted to Inpatient Rehabilitation

Schopp, Laura H.; Clark, Mary Jo; Mazurek, Micah O.; Hagglund, Kristofer J.; Acuff, Michael; Sherman, Ashley; Childers, Martin K.

doi:10.1097/01.phm.0000228617.94079.4a

Cited by 49 publications

(43 citation statements)

References 38 publications

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“…Higher doses of testosterone were also effective in reducing the MP-induced upregulation of the known muscle atrophy genes FOXO1, MAFbx and REDD1. When taken together with the findings that the trauma of acute SCI and that of glucocorticoid administration both serve to reduce circulating testosterone levels in men, [17][18][19] our findings suggest the possibility that there may be a clinical benefit to the use of replacement doses of testosterone in spinal cord-injured men administered high-dose MP therapy at the time of injury. This possibility will be an important area for future study.…”

Section: Discussionmentioning

confidence: 97%

“…10,[14][15] The protective actions of endogenous testosterone are likely to be diminished after SCI in men, particularly during the first few weeks or months after acute injury, because circulating levels of testosterone are often markedly reduced. 16,17 Administration of glucocorticoid medications themselves have been associated with reduced circulating levels of testosterone, and these agents may produce a state of relative or absolute hypogonadism, 18,19 which may be speculated to worsen any state of hypogonadism already present as a result of the stress of trauma or other medical conditions associated with SCI.…”

Section: Introductionmentioning

confidence: 99%

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Testosterone reduced methylprednisolone-induced muscle atrophy in spinal cord-injured rats

Collier

Pan

et al. 2011

Spinal Cord

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Study design: Male rats with complete transections of the spinal cord were administered vehicle or methylprednisolone (MP) for 24 h, with or without infusion, for 7 days, of testosterone at either a replacement or low pharmacological doses. Muscles were collected at 7 days after SCI. Objective: The objective of this study is to determine, in a rat model of complete spinal cord transection, whether testosterone reduces muscle atrophy or upregulates muscle atrophy-linked genes, induced by 24 h of MP administration at doses comparable to those prescribed in man during the period immediately following acute spinal cord injury (SCI) in an attempt to preserve neurological function. Results: MP significantly reduced the mass of triceps, soleus and plantaris, and significantly increased expression of genes that promote atrophy. Testosterone significantly reduced muscle atrophy induced by MP, but did not prevent it; there was no difference between low-or high-dose testosterone in reducing MP-induced muscle loss. High-dose testosterone reduced expression of muscle atrophy genes more than did low dose. Testosterone-induced declines in mRNA levels for these atrophy-associated genes did not correlate well with protection against MP-induced muscle atrophy. Conclusions: MP induces marked and lasting changes in the biology of muscle that persisted for at least 7 days, or 6 days after MP has been eliminated from the body. Testosterone partially protected against muscle atrophy and gene expression changes caused by 1 day of MP.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Testosterone reduced methylprednisolone-induced muscle atrophy in spinal cord-injured rats

Collier

Pan

et al. 2011

Spinal Cord

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“…Çalışmamızla da benzer olarak özellikle fertilite ilişkili hormonal profilerin değerlendirildi-ği çalışmalar yapılmıştır. [5][6][7][8][9][10] Çalışmamızda değerlendirdiğimiz değişkenlerden biri PRL hormonu idi.Bilindiği gibi PRL hormonu dopaminin tonik supresyonu altındadır. Spinal kord hasarı sonrası sempatik sinir sistemi üzerindeki supraspinal kontrol mekanizmasının ortadan kalkması sonucu santral dopaminerjik tonusun azalması ile hiperprolaktinemi ortaya çıkar.…”

Section: Discussionunclassified

“…Clark MJ ve Shopp LH'nın yaptıkları çalış-malarda da omurilik yaralanmalı hastalarda belirgin olarak testosteron düzeyleri düşük saptanmıştır. 8,9 Clark MJ ve arkadaşlarının çalışmalarında testosteron düzey düşük-lüğünün travma sonrası özellikle ilk bir yıllık dönemde belirgin olduğu saptanmıştır. 8 Çalışmamızdaki bulguların aksine Perkash ve arkadaşlarının yaptığı çalışmada FSH, PRL ve östradiol düzeyleri normalken, LH ve testosteron seviyeleri sağlıklı bireylere göre yüksek bulunmuştur.…”

Section: Discussionunclassified

“…Omurilik yaralanmaları bu nörohormonal düzeni bozarak her iki cinsiyette de erken dönemlerde benzer cevaplar oluşturmasına karşın zaman içerisinde özellikle reprodüktif performansı ve fertiliteyi etkileyen hormonlar ve hormon cevaplarında farklı sonuçlar doğurur. [3][4][5][6][7][8][9] Çalışmamızın amacı omurilik yaralanması hikayesi olan erkek hastalarda özellikle erken dönemde genellikle gö-zardı edilen fertilite ilişkili hormonal profillerdeki değişik-likleri incelemek, saptanan değişiklikleri sağlıklı gönüllü-lerden oluşan kontrol grubuyla karşılaştırmak ve izlenen değişimlerin klinik yansımalarını değerlendirmekti.…”

Section: Introductionunclassified

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Fertility relevant hormones in men with spinal cord injury: case control study

Gökkaya¹,

Güzel²,

Gökkaya³

et al. 2012

Sakarya Med J

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Objective: Individual and social effects of spinal cord injury is an important cause of morbidity. After the spinal cord injury substantial hormonal changes are seen. The aim of the study was to evaluate the fertility-related hormonal profiles and the clinic implications in men with traumatic spinal cord injury. Materials and Methods: Total of 59 patients with spinal cord injury (complete (Group 1, n = 41) and incomplete (Group 2, n = 18)) and 54 healthy volunteers (Group 3) participated in this study. Blood samples were collected for determination of folliculasr stimulating hormone (FSH), luteining hormone (LH), prolactin (PRL), total testesterone (t-testosteron), free testesterone (f-testosteron), dihydroepiandrostedion) DHEA-S, estradiol levels of all patients and volunteers included in the study. In addition, all patients and volunteers completed IIEF(International Index of Erectile Function) questionnaire. Patients (Group 1 and Group 2) and healthy volunteers (Group 3) were compared with each other. Results: PRL levels of both SCI groups (Group 1 and Group 2), were significantly higher (p <0.05) than the control group (Group 3). Additionally, t -testosterone and f-testosteron levels were lower in the patients with complete injuries than the control group (p <0.05). IIEF scores were significantly lower (p <0.01) in the patient groups (Group 1 and Group 2) than the control group (Group 3). Conclusion: Spinal cord-injured patients, in terms of hormonal changes and sexual dysfunction, should be followed with fertility-related hormone profiles and IIEF scores.

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Blunt and Penetrating Neck Trauma

Kobayashi

2012

Surgical Critical Care and Emergency Surgery

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Testosterone Levels Among Men with Spinal Cord Injury Admitted to Inpatient Rehabilitation

Cited by 49 publications

References 38 publications

Testosterone reduced methylprednisolone-induced muscle atrophy in spinal cord-injured rats

Testosterone reduced methylprednisolone-induced muscle atrophy in spinal cord-injured rats

Fertility relevant hormones in men with spinal cord injury: case control study

Blunt and Penetrating Neck Trauma

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