Testosterone Rapidly Increases Neural Reactivity to Threat in Healthy Men: A Novel Two-Step Pharmacological Challenge Paradigm

Goetz, Stefan; Tang, Lingfei; Thomason, Moriah E.; Diamond, Michael P.; Hariri, Ahmad R.; Carré, Justin M.

doi:10.1016/j.biopsych.2014.01.016

Cited by 148 publications

(113 citation statements)

References 75 publications

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“…Pharmacological challenge research indicates that a single administration of T increases threat-related amygdala, hypothalamic, and periaqueductal gray reactivity to angry facial expressions in healthy men (18). These findings parallel evidence in women in which a single administration of T increases amygdala and hypothalamic reactivity to angry facial expressions (19)(20)(21).…”

Section: Introductionmentioning

confidence: 59%

Exogenous Testosterone Rapidly Increases Aggressive Behavior in Dominant and Impulsive Men

Carré

Geniole

Ortiz

et al. 2017

Biological Psychiatry

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186

109

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Section: Introductionmentioning

confidence: 59%

Exogenous Testosterone Rapidly Increases Aggressive Behavior in Dominant and Impulsive Men

Carré

Geniole

Ortiz

et al. 2017

Biological Psychiatry

Self Cite

186

109

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“…There is now a growing body of evidence indicating that effects of OT on cognitive and behavioral processes depend critically on social-contextual and individual difference factors (see Bartz et al 2011 for a review). There is also a wealth of research using single T administration protocols, mainly in women (see Bos et al 2012), but also recently implemented in men (Goetz et al 2014). The findings from the current studies indicate that it will be important to assess the extent to which trait anxiety moderates the effect of T administration on human aggressive behavior -and other behavioral traits linked to T (e.g., competitive motivation, affiliative behavior, trust ratings, etc.…”

Section: Discussionmentioning

confidence: 82%

Trait Anxiety Moderates the Relationship Between Testosterone Responses to Competition and Aggressive Behavior

Norman

Moreau

Welker

et al. 2014

Adaptive Human Behavior and Physiology

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Testosterone (T) concentrations change rapidly in the context of human competition, and these changes in neuroendocrine function may serve to modulate future aggressive behavior. However, an increase in T during competition does not translate into aggressive behavior among all individuals. Here, we examined the extent to which individual differences in trait anxiety moderate the relationship between T responses to competition and aggressive behavior. Across two studies, we found that T responses to competition were positively correlated with subsequent aggression, but only among men scoring relatively low in trait anxiety. Trait anxiety did not moderate the relationship between T reactivity and aggression in women. These findings highlight the importance of considering individual difference in trait anxiety when examining the neuroendocrine correlates of human aggression.

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“…We chose this time-course for the assessment of face preferences as previous pharmacokinetic work indicates that T concentrations begin to rise 2 hours after gel application and peak concentrations occur 3 hours after application (Eisenegger et al, 2013). Moreover, recent evidence suggests that a single administration of T can rapidly (within 45 to 90 min) modulate brain function (see Goetz et al, 2014;van Wingen et al, 2008). Day 3 took place two weeks following Day 2 and was identical in nature to Day 2 described above, with the exception that participants received whichever drug they did not receive on their original testing day (AndroGel® or placebo).…”

Section: Experiments 1 Methodsmentioning

confidence: 99%

Effects of exogenous testosterone and mating context on men's preferences for female facial femininity

Bird

Welling

Ortiz

et al. 2016

Hormones and Behavior

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Correlational research suggests that men show greater attraction to feminine female faces when their testosterone (T) levels are high. Men's preferences for feminine faces also seem to vary as a function of relationship context (short versus long-term).However, the relationship between T and preferences for female facial femininity has yet to be tested experimentally. This thesis examined the causal role of T in modulating preferences for facial femininity across both short and long-term mating contexts, using two separate experiments. Results of Experiment 1 (within-subject design, n = 24)showed that participants significantly preferred feminized versus masculinized versions of women's faces. Further, participants showed a stronger preference for feminine female faces in the short-versus the long-term context after they received T, but not after they received placebo. Post-hoc analyses suggest that this effect was driven by a lower preference for feminine faces in the long-term context when on T relative to placebo.Results from Experiment 2 (between-subject design, n = 93) were highly consistent with those of Experiment 1: men demonstrated a significant preference for feminized female faces in the short-versus the long-term context after T, but not after placebo administration, and this effect was driven by lower preferences for feminine faces in the long-term context when on T relative to placebo. Collectively, these findings provide the first causal evidence that T modulates men's preferences for facial femininity as a function of mating context.

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Testosterone Rapidly Increases Neural Reactivity to Threat in Healthy Men: A Novel Two-Step Pharmacological Challenge Paradigm

Cited by 148 publications

References 75 publications

Exogenous Testosterone Rapidly Increases Aggressive Behavior in Dominant and Impulsive Men

Exogenous Testosterone Rapidly Increases Aggressive Behavior in Dominant and Impulsive Men

Trait Anxiety Moderates the Relationship Between Testosterone Responses to Competition and Aggressive Behavior

Effects of exogenous testosterone and mating context on men's preferences for female facial femininity

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