Testosterone Recovery Following Short Course Androgen Deprivation Therapy and Stereotactic Body Radiotherapy Correlates Closely with Improvements in Patient-Reported Hormonal and Sexual Domain Scores

Abstract

climbing a flight of stairs (pZ0.004), and more shortness of breath when sitting (p<0.001), walking one block (pZ0.007), and going up a flight of stairs (pZ0.03) compared to those who received SURG. Conclusion: SEER-MHOS database provides useful information for patient-reported outcomes in patients receiving definitive therapy for early stage lung cancer. Compared to SURG, patients older than 65 who received RT had lower PSC scores and more difficulty with SOB, secondary to poorer performance status at baseline vs. treatment effects. Limitations include low number of patients receiving RT, lack of information of the type of RT or SURG received, and lack of direct comparison between individual patients pre-and post-diagnosis.

Salvage re-irradiation using stereotactic body radiation therapy for locally recurrent prostate cancer: the impact of castration sensitivity on treatment outcomes

“…Cuccia et al [ 43 ] have reported a series of salvage SBRT in which the majority of patients did not receive ADT with good local control and the benefit of delaying negative impact on quality of life due to castration. We chose to offer a short course of ADT based on a number of assumptions: (a) Androgen depleted cancer cells are more radiosensitive [ 44 ]; (b) The addition of ADT to radiotherapy improves PFS and DMFS in recurrent prostate cancer following surgery [ 44 ]; (c) A short duration of ADT is associated with a high incidence of testosterone recovery in the vast majority of men [ 45 ]; (d) 83% of our cohort had high risk disease features at recurrence. Duration of concurrent ADT in the setting of salvage SBRT is also an area of debate.…”